United States v. Joseph Castronuovo, M.D. ( 2016 )


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  •                Case: 14-11765       Date Filed: 05/17/2016       Page: 1 of 43
    [DO NOT PUBLISH]
    IN THE UNITED STATES COURT OF APPEALS
    FOR THE ELEVENTH CIRCUIT
    ________________________
    No. 14-11765
    ________________________
    D.C. Docket No. 9:10-cr-80149-KAM-30
    UNITED STATES OF AMERICA,
    Plaintiff-Appellee,
    versus
    JOSPEH CASTRONUOVO, M.D.,
    CYNTHIA CADET, M.D.,
    Defendants-Appellants.
    ________________________
    Appeals from the United States District Court
    for the Southern District of Florida
    _______________________
    (May 17, 2016)
    Before WILLIAM PRYOR and FAY, Circuit Judges, and ROBRENO, * District
    Judge.
    * Honorable Eduardo C. Robreno, United States District Judge for the Eastern District of
    Pennsylvania, sitting by designation.
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    ROBRENO, District Judge:
    Defendants Joseph Castronuovo and Cynthia Cadet (“Defendants”) appeal
    their judgments of conviction under 
    18 U.S.C. § 1957
     for conspiracy to engage in
    monetary transactions affecting interstate commerce in criminally derived property
    exceeding $10,000, also known as conspiracy to commit money laundering. After
    reviewing the record and hearing oral argument, we affirm the judgement of
    conviction for both Defendants.
    I.      BACKGROUND
    Defendants were indicted by a federal grand jury in the Southern District of
    Florida and charged alongside thirty other individuals for their roles in an illegal
    “pill mill” operation involving two pain management clinics owned by Christopher
    George: American Pain and Executive Pain. The clinics’ operations depended on
    doctors, like Defendants, who were licensed to prescribe and dispense narcotics.
    George paid the doctors a portion of their salary by check and the rest by cash.
    Before receiving their weekly paychecks, the doctors would sign forms that stated
    “I did not see anything illegal happen or do anything illegal at the office.”
    Defendant Cadet began working at American Pain, formerly called South
    Florida Pain, after responding to a Craigslist ad for employment. During her
    interview, George told Cadet that “we prescribe medication here for people that
    2
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    allege to be in pain, and that’s all we do.” He told her that she would earn $75 per
    patient and $1,000 per week for the use of her dispensing license.
    Once employed, Cadet saw as many as 100 patients per day. On one
    particular day, surveillance videos and patient records indicated that Cadet spent an
    average of 4 minutes and 40 seconds with each patient, and prescribed a total of
    15,860 Oxycodone pills at 30 mg each; 5,790 Oxycodone pills at 15 mg each; and
    3,600 Xanax pills at 2 mg each. One patient testified at trial that Cadet prescribed
    pills to him after merely checking his blood pressure and reviewing his
    prescriptions from George’s other clinic. Cadet also signed drug-supplier forms
    that falsely underestimated how many patients were seen daily, how many received
    prescriptions for controlled substances, and how many were from other states.
    The Internal Revenue Service (“IRS”) determined that Cadet received a total
    of $1,217,125 in compensation during her tenure. And Drug Enforcement Agency
    (“DEA”) records showed that 878,600 Oxycodone pills were dispensed under
    Cadet’s license between 2008 and 2010.
    Defendant Castronuovo also responded to one of George’s employment ads
    for a position at Executive Pain. During the interview, George stated that
    Castronuovo would be paid $75 per patient to prescribe pain medication and
    shared sample charts displaying patients’ Oxycodone and Xanax prescriptions.
    George described the clinics’ “business model” during the interview and testified
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    that he “wouldn’t have hired [Castronuovo]” if Castronuovo had not agreed to the
    clinics’ prescription practices.
    A statistical sample of Castronuovo’s patient files showed that Castronuovo
    engaged in a “pattern” of prescribing Oxycodone, Xanax, and sometimes Soma.
    Like Cadet, Castronuovo signed documents falsely stating the number of patients
    from out of state and the number of patients receiving controlled substances.
    Because Castronuovo worked only part time, George paid him up to $200 per day
    for use of his dispensing license. But Castronuovo also received $75 for each
    patient he saw. Moreover, seized surveillance footage corroborated that he
    received $3,200 for seeing 40 patients on one particular day and $4,025 for seeing
    51 patients on another day. The IRS determined that Castronuovo received a total
    of $164,025 during his tenure. And DEA records showed that 328,600 Oxycodone
    pills were dispensed under Castronuovo’s license between 2008 and 2010.
    On March 3, 2010, government agents executed search warrants at both
    clinics and recovered surveillance videos from American Pain’s security cameras.
    Agents also seized all patient files and patient logs, which listed how many patients
    each doctor saw and dictated each doctor’s pay.
    On January 18, 2011, before he was charged with any crimes, Castronuovo
    and his attorney met with prosecutors and DEA agents to describe his prescription
    practices and compensation from the clinic. Castronuovo stated that he received
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    $75 per patient, with a minimum daily total of $1,500. He explained that George
    paid him in cash during his first five months of employment and then by check.
    The original indictment charged George, the clinics’ owner, with unlawful
    possession of a firearm and ammunition, in violation of 
    18 U.S.C. §§ 922
    (g)(1) and
    924(a)(2). Then, the first superseding indictment charged thirty-two clinic staff
    members and doctors, including Cadet and Castronuovo. Therein, Cadet was
    charged as part of a racketeering conspiracy, in violation of 
    18 U.S.C. § 1961
    (1)
    and (5); money laundering conspiracy, in violation of 
    18 U.S.C. § 1956
    (h); and an
    Oxycodone trafficking conspiracy, in violation of 
    21 U.S.C. § 841
    (a)(1). Both
    Cadet and Castronuovo were charged with mail/wire fraud, in violation of 
    18 U.S.C. §§ 1341
     and 1343.
    After a majority of the codefendants pled guilty, Cadet and Castronuovo
    were charged in a second superseding indictment with conspiracy to traffic in
    Oxycodone, in violation of 
    21 U.S.C. §§ 846
    , 841(a)(1), and 859(a), and
    conspiracy to engage in money laundering, in violation of 
    18 U.S.C. §§ 1956
    (h)
    and 1957. In addition, Cadet was charged individually with two counts of
    Oxycodone and Alprazolam distribution resulting in deaths, in violation of 
    21 U.S.C. § 841
    (a)(1) and (b)(1)(C); five counts of Oxycodone distribution resulting
    in deaths, in violation of 
    21 U.S.C. § 841
    (a)(1) and (b)(1)(C); and one count of
    conspiracy to distribute anabolic steroids, in violation of 
    21 U.S.C. §§ 841
    (a)(1)
    5
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    and 829(e). Castronuovo was charged individually with one count of Oxycodone
    distribution, in violation of 
    21 U.S.C. §§ 846
    , 841(a)(1) and 859(a), and two counts
    of Oxycodone distribution resulting in deaths, in violation of 
    21 U.S.C. § 841
    (a)(1)
    and (b)(1)(C).
    Defendants pled not guilty and proceeded to trial. After the district court
    denied Castronuovo’s motion to sever his trial from Cadet’s, Defendants were tried
    together and agreed that objections made by one were joined by the other unless
    otherwise stated.
    After a 31-day trial and four days of deliberations, the jury reported that they
    had reached a verdict and submitted the verdict forms. When the district court
    examined the returned verdict forms, it noted that “[t]he forms are not completely
    filled out” and instructed the jury to return to the deliberation room to “fill out
    either guilty or not guilty on all of the counts.” The district court explained that
    “[y]ou can’t leave it blank . . . We need to know what your decision is on each of
    those counts where you’ve left it blank.” The court told the jury to send a note if
    they did not understand the instructions, and no party objected to these directions.
    Shortly thereafter, the jury sent a note reporting that it was “deadlocked” on
    certain counts. After all parties agreed, the district court gave a modified Allen
    instruction based on the Eleventh Circuit Pattern Jury Instructions. Approximately
    2 to 2 ½ hours later, the jury returned a guilty verdict against Defendants on the
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    money laundering conspiracy count. Defendants were acquitted on all other
    charges.
    The district court entered judgment against both Defendants after denying
    their post-trial motions. It sentenced Castronuovo to 18 months’ imprisonment and
    two years’ supervised release. It sentenced Cadet to 78 months’ imprisonment and
    two years’ supervised release. Defendants now appeal.
    II.    STANDARDS OF REVIEW
    Numerous standards of review govern the issues on appeal. “We review the
    sufficiency of evidence to support a conviction de novo.” United States v. Taylor,
    
    480 F.3d 1025
    , 1026 (11th Cir. 2007). As to a cumulative error argument, we
    review de novo the cumulative impact of the alleged errors at trial. United States v.
    Dohan, 
    508 F.3d 989
    , 993 (11th Cir. 2007). We also review a claim of
    prosecutorial misconduct de novo “because it is a mixed question of law and fact.”
    United States v. Duran, 
    596 F.3d 1283
    , 1299 (11th Cir. 2010).
    “We review a district court’s denial of a motion to dismiss an indictment for
    abuse of discretion but, in determining whether the court abused its discretion, we
    resolve issues of law de novo.” United States v. Cavallo, 
    790 F.3d 1202
    , 1219
    (11th Cir. 2015). We also review de novo the issue whether jury instructions
    constructively amended the indictment, United States v. Gutierrez, 
    745 F.3d 463
    ,
    473 (11th Cir. 2014), but when a defendant raises this argument for the first time
    7
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    on appeal, we review it for plain error, United States v. Madden, 
    733 F.3d 1314
    ,
    1322 (11th Cir. 2013).
    “The grant or denial of a motion to suppress evidence is reviewed in this
    Court as a mixed question of law and fact. We assess the district court’s findings of
    fact under the clearly erroneous standard and review the application of the law to
    the facts de novo.” United States v. Perkins, 
    348 F.3d 965
    , 969 (11th Cir. 2003)
    (citation omitted).
    We review for abuse of discretion a district court’s ruling on a severance
    motion, its limitation on the scope of cross-examination, its decision to give an
    Allen charge, and its refusal to give a requested jury instruction. See United States
    v. Maxwell, 
    579 F.3d 1282
    , 1295 (11th Cir. 2009) (limitation of cross-
    examination); United States v. Westry, 
    524 F.3d 1198
    , 1216 (11th Cir. 2008) (jury
    instruction); United States v. Woodard, 
    531 F.3d 1352
    , 1364 (11th Cir. 2008)
    (Allen charge); United States v. Kennard, 
    472 F.3d 851
    , 859 (11th Cir. 2006)
    (severance motion). But where a defendant does not request specific instructions
    and fails to object at trial to the district court’s failure to include specific
    instructions, we review for plain error only. United States v. Pena, 
    684 F.3d 1137
    ,
    1151 (11th Cir. 2012).
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    III.   DISCUSSION
    Defendants 1 raise a number of issues on appeal: (1) whether there was
    sufficient evidence to convict Defendants for money laundering conspiracy;
    (2) whether the district court erred in denying Castronuovo’s motion to dismiss the
    Second Superseding Indictment; (3) whether the district court erred in dismissing
    Castronuovo’s motion to suppress his pre-indictment statements; (4) whether the
    district court erred in denying Castronuovo’s motion to sever; and (5) whether the
    district court coerced the jury by effectively delivering two Allen charges.
    Also, Cadet raises the issue (6) whether she should be granted a new trial
    based on the cumulative prejudicial effect of: (a) the district court’s constructive
    amendment of the indictment; (b) the prosecutor’s argument based on “guilt by
    association”; (c) the district court’s limitation on the scope of cross-examination;
    and (d) the district court’s failure to give a good faith instruction for the money
    laundering conspiracy charge. Each issue is discussed in turn.
    A.      Sufficiency of the Evidence as to the Money Laundering Convictions
    Title 
    18 U.S.C. § 1956
    (h) makes it unlawful to conspire to violate any
    provision of §§ 1956 or 1957. In turn, § 1957 makes it unlawful to engage in
    monetary transactions in property derived from “specified unlawful activity.” 18
    1
    Castronuovo moved to adopt three of Cadet’s arguments on appeal, and we granted the
    motion. Those adopted arguments are designated by footnote in this opinion.
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    43 U.S.C. § 1957
    . Together, these provisions make it unlawful to engage in a money
    laundering conspiracy.
    Here, the jury convicted Defendants of conspiring to violate § 1957 by
    agreeing “to knowingly engage and attempt to engage in monetary transactions . . .,
    in criminally derived property of a value greater than $10,000.” The “specified
    unlawful activity” was “the distribution, dispensing and possession with intent to
    distribute and dispense[] oxycodone, a Schedule II narcotic controlled substance,
    outside the scope of professional practice and not for a legitimate medical
    purpose.”
    To establish the existence of a money laundering conspiracy, the
    government was required to prove beyond a reasonable doubt “(1) an agreement
    between two or more persons to commit a money-laundering offense; and
    (2) knowing and voluntary participation in that agreement by the defendant.”
    United States v. Moran, 
    778 F.3d 942
    , 962 (11th Cir. 2015) (quoting United States
    v. Broughton, 
    689 F.3d 1260
    , 1280 (11th Cir. 2012)). No evidence of willfulness
    or specific intent is required, Dohan, 
    508 F.3d at 994
    , and conviction does not
    require proof of an overt act in furtherance of the conspiracy. Whitfield v. United
    States, 
    543 U.S. 209
    , 214 (2005).
    Defendants argue that the government did not present sufficient evidence for
    the jury to find beyond a reasonable doubt that they conspired to commit money
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    laundering. The question for our review is “whether, after viewing the evidence in
    the light most favorable to the prosecution, any rational trier of fact could have
    found the essential elements of the crime beyond a reasonable doubt.” Musacchio
    v. United States, 
    136 S. Ct. 709
    , 715 (2016) (quoting Jackson v. Virginia, 
    443 U.S. 307
    , 319 (1979)). “That limited review does not intrude on the jury’s role ‘to
    resolve conflicts in the testimony, to weigh the evidence, and to draw reasonable
    inferences from basic facts to ultimate facts.’” 
    Id.
     (quoting Jackson, 
    443 U.S. at 319
    ).
    1.     An agreement between two or more persons to
    commit the money laundering offense
    To satisfy the first element of money laundering conspiracy, no evidence of
    a “formal agreement” is required; instead, the government may “demonstrate by
    circumstantial evidence a meeting of the minds to commit an unlawful act.” United
    States v. Arias-Izquierdo, 
    449 F.3d 1168
    , 1182 (11th Cir. 2006). “Proof that the
    accused committed an act which furthered the purpose of the conspiracy is an
    example of the type of circumstantial evidence the government may introduce to
    prove the existence of agreement.” 
    Id.
     The government need not prove that a
    conspiracy participant knew all details of the conspiracy or participated in its every
    aspect. United States v. Arbane, 
    446 F.3d 1223
    , 1229 (11th Cir. 2006) (citing
    United States v. Fernandez, 
    797 F.2d 943
    , 948–49 (11th Cir. 1986)). Rather, the
    government need only prove that the defendant knew “the essential nature of the
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    conspiracy.” Moran, 778 F.3d at 960 (quoting United States v. Vernon, 
    723 F.3d 1234
    , 1273 (11th Cir. 2013)).
    Here, viewing the evidence in the light most favorable to the government, a
    rational jury could have found, beyond a reasonable doubt, an agreement between
    two or more persons to commit a money laundering offense. First, the evidence
    showed that Defendants knew the conspiracy’s essential nature: to obtain payment
    of funds received through the illegal sale of Oxycodone at the clinics. During
    Cadet’s interview, George told her that “we prescribe medication here for people
    that allege to be in pain, and that’s all we do.” He told her that she would earn $75
    per patient and $1,000 per week for the use of her dispensing license. Similarly,
    during Castronuovo’s interview, George told him that he would be paid $75 per
    patient and showed him sample charts displaying “the types of medication that
    were prescribed there.” George described the clinics’ “business model” during the
    interview and testified that he “wouldn’t have hired [Castronuovo]” if he had not
    agreed to the clinics’ prescription practices. In addition to the $75 fee per patient,
    George paid him up to $200 per day to use his dispensing license.
    While there is no direct evidence that Defendants separately agreed to
    deposit their paychecks into their personal bank accounts, direct evidence is rarely
    available to prove a conspiracy’s existence. United States v. Pineiro, 
    389 F.3d 1359
    , 1369 (11th Cir. 2004). Here, George paid Defendants, in part, with checks
    12
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    drawn from a bank account at Bank of America. Defendants then accepted the
    checks made payable to them with knowledge that the checks’ funds were derived
    from the clinics’ operations. Defendants also endorsed and negotiated the checks
    through a financial institution in an amount exceeding $10,000. Based on this
    evidence and common knowledge that checks must be negotiated to transfer
    possession of their funds, a rational juror could conclude that Defendants accepted
    the checks with the intent to deposit them into their personal bank accounts. See
    United States v. Gainey, 
    111 F.3d 834
    , 836 (11th Cir. 1997) (explaining that “the
    law permits jurors to ‘apply their common knowledge, observations and
    experiences in the affairs of life’” when “evaluating the facts of a case” (quoting
    United States v. Cruz-Valdez, 
    773 F.2d 1541
    , 1546 (11th Cir. 1985) (en banc))).
    Thus, the evidence was sufficient for a rational juror to conclude that Defendants
    agreed to engage in monetary transactions in criminally derived property valued
    greater than $10,000 by accepting their paychecks with knowledge that the funds
    were derived from the clinics’ unlawful activity.
    Defendants 2 argue that a conviction for money laundering conspiracy on
    these facts renders § 1956(h) “impermissibly broad” because “[w]ithout insisting
    upon proof of a separate agreement, virtually any conspiracy involving the
    exchange of funds would automatically be punishable as money laundering.” The
    2
    Castronuovo adopts this argument made by Cadet.
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    Court need not consider this argument further. As discussed above, there was
    sufficient evidence for a rational jury to conclude beyond a reasonable doubt that
    Defendants separately agreed to engage in financial transactions upon accepting
    profits from the clinics’ operations. 3
    Castronuovo also contends that the evidence was insufficient because it
    showed multiple conspiracies rather than a single conspiracy. According to
    Castronuovo, the evidence reflected the kind of “rimless wheel” or “hub-and-
    spoke” conspiracy described in Kotteakos v. United States, 
    328 U.S. 750
    , 755
    (1946), and United States v. Chandler, 
    388 F.3d 796
    , 807 (11th Cir. 2004). The
    courts in Kotteakos and Chandler reversed convictions because the types of
    conspiracies proven at trial constituted material variances from the indictments in
    those cases, and Castronuovo contends that the same result should be reached here.
    “A variance occurs when the facts proved at trial deviate from the facts
    contained in the indictment but the essential elements of the offense are the same.”
    United States v. Keller, 
    916 F.2d 628
    , 634 (11th Cir. 1990). A variance is
    reversible error only when “the facts established at trial materially diverge from the
    3
    Defendants additionally cite the rule of lenity to support this argument, but the rule of
    lenity is inapplicable, because there is not a “grievous ambiguity or uncertainty” in § 1956(h).
    United States v. Maupin, 
    520 F.3d 1304
    , 1307 (11th Cir. 2008) (quoting Muscarello v. United
    States, 
    524 U.S. 125
    , 138 (1998)).
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    facts in the indictment and the defendant suffers substantial prejudice as a result.”
    United States v. Weissman, 
    899 F.2d 1111
    , 1114 (11th Cir. 1990).
    A variance is material “if the government proves multiple conspiracies
    under an indictment alleging only a single conspiracy.” United States v. Castro, 
    89 F.3d 1443
    , 1450 (11th Cir. 1996) (citing Kotteakos, 
    328 U.S. 750
    ). On review, we
    look at the evidence in the light most favorable to the government and ask whether
    a reasonable trier of fact could have determined beyond a reasonable doubt that a
    single conspiracy existed. United States v. Seher, 
    562 F.3d 1344
    , 1366 (11th Cir.
    2009). We will not disturb the jury’s finding of a single conspiracy if it is
    supported by substantial evidence. 
    Id.
     To determine whether the jury could have
    found a single conspiracy, we consider (1) whether a common goal existed; (2) the
    nature of the underlying scheme; and (3) the overlap of participants. United States
    v. Edouard, 
    485 F.3d 1324
    , 1347 (11th Cir. 2007).
    Here, viewing the evidence in the light most favorable to the government, a
    rational juror could have found beyond a reasonable doubt that there was a single,
    overarching conspiracy. Defendants shared a common goal—to obtain payment
    from the clinics’ illegal operations—and each Defendant acted in concert to further
    this goal. The clinics’ continued operation relied on Defendants’ and other doctors’
    willingness to prescribe Oxycodone in mass quantities. The nature of the clinics’
    scheme relied on using those same doctors’ dispensing licenses to obtain the pills
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    that the clinics sold. Moreover, evidence that Defendants sold pills to the same
    patients and George instructed Castronuovo to shadow Cadet as training indicates a
    direct overlap in participants. Because this evidence was sufficient for a reasonable
    jury to find that a single conspiracy existed, there was no material variance.
    2.     Knowledge and Intent
    As to the second element of money laundering conspiracy, a rational jury
    could have found beyond a reasonable doubt that Defendants agreed to commit a
    money laundering offense “with the requisite knowledge and intent.” United States
    v. Magluta, 
    418 F.3d 1166
    , 1174 (11th Cir. 2005). Specifically, the evidence
    showed that Defendants knew “that the property involved . . . represent[ed] the
    proceeds of some form of unlawful activity.” 
    18 U.S.C. § 1956
    (a)(1); see also
    United States v. Martinelli, 
    454 F.3d 1300
    , 1312 n.8 (11th Cir. 2006).
    Other clinic doctors and personnel discussed the clinics’ adverse media
    coverage with Cadet and in her presence. And Castronuovo testified that he
    continued to work at the clinic despite knowing that its operations were illegal,
    referring to the clinics’ patients as “junkies” and “pillbillies.” Viewing this
    evidence in the light most favorable to the government, a rational juror could
    conclude that Defendants knew that they were being paid for their roles in the
    clinics’ unlawful distribution of narcotics.
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    Defendants’ acquittal on the underlying drug conspiracy charge does not
    affect the sufficiency of the evidence as to this second element. “It is by now
    abundantly clear that in a money laundering case (or in a money laundering
    conspiracy case), the defendant need not actually commit the alleged specified
    unlawful activity.” 
    Id. at 1312
    . Moreover, “inconsistent jury verdicts are not
    necessarily a cause for reversal of a conviction.” United States v. Lozano-
    Hernandez, 
    89 F.3d 785
    , 789 (11th Cir. 1996). Indeed, we have maintained that
    conviction on only one of two related counts may be upheld where “[d]ifferent
    elements comprise the two offenses.” 
    Id.
     (citing United States v. Powell, 
    469 U.S. 57
    , 65–67 (1984)).
    Here, different elements comprise the drug trafficking conspiracy and
    money laundering conspiracy offenses. Compare 
    21 U.S.C. §§ 841
    (a)(1), 846,
    859(a), with 
    id.
     §§ 1956(h), 1957. And as the district court noted, even though the
    jury ultimately determined that Defendants did not personally distribute narcotics
    unlawfully, there was evidence for the jury to nevertheless find “that the other
    medical doctors were engaging in such unlawful conduct, that the money they
    received for working at the clinics was proceeds from that illegal activity, and that
    they agreed to conspire with the others to launder those illegal proceeds.”
    Cadet argues that she did not know that her prescriptions were for an
    illegitimate medical purpose. She avers that her income was derived on a per-
    17
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    patient basis; she did not have ownership interest in the clinics; and she did not
    receive money directly from narcotics sold at other clinics. But § 1957 specifically
    states that “[i]n a prosecution for an offense under this section, the Government is
    not required to prove that the defendant knew that the offense from which the
    criminally derived property was derived was specified unlawful activity.” 
    18 U.S.C. § 1957
    (c). Plus, Cadet’s conviction was not for substantive promotional
    money laundering, so the government was not required to prove that she personally
    reinvested the illegal proceedings into the clinics’ criminal activities. Compare 
    18 U.S.C. § 1956
     (a)(1)(A)(i) (promotional money laundering), with 
    id.
     § 1957(a)
    (monetary transactions derived from specified unlawful activity). And despite
    receiving some payments directly from patients, who she saw only by virtue of her
    position at the clinic, Cadet also received $1,000 per week for use of her
    dispensing license. Because there was sufficient evidence for a rational jury to find
    both elements of money laundering conspiracy beyond a reasonable doubt, we will
    uphold Defendants’ convictions.
    B. Motion to Dismiss Second Superseding Indictment for Grand Jury Abuse
    Castronuovo next argues that the district court erred in denying his motion to
    dismiss the second superseding indictment for grand jury abuse. He specifically
    alleges prosecutorial vindictiveness and prosecutorial misconduct. But dismissing
    an indictment is an “extreme sanction which should be infrequently utilized.”
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    United States v. O’Keefe, 
    825 F.2d 314
    , 318 (11th Cir. 1987). And the district
    court determined that such an extreme sanction was not warranted here.
    1.    Second superseding indictment as retaliation
    First, Castronuovo contends that the prosecutor vindictively used the second
    superseding indictment to retaliate against Castronuovo for exercising his
    procedural rights—namely, his right to plead not guilty and his right to move for
    severance.
    Dismissal of an indictment for prosecutorial vindictiveness is based on the
    principle that a defendant “may not be punished for exercising a protected statutory
    or constitutional right.” United States v. Goodwin, 
    457 U.S. 368
    , 372 (1982). A
    rebuttable presumption of vindictiveness arises where the government takes
    unilateral action, such as obtaining a superseding indictment alleging additional or
    more serious charges, in a context that indicates a reasonable likelihood of
    vindictiveness as a response to the defendant’s exercise of his rights. 
    Id.
     at 372–77.
    Where the facts do not give rise to a presumption, the defendant may show actual
    vindictiveness by proving that the government acted solely to penalize him. 
    Id.
     at
    380–81 & n.12.
    No grounds for a presumption of vindictiveness exist here. After
    Castronuovo decided to plead not guilty to the mail/wire fraud count in the first
    superseding indictment, the government continued its investigation into patient
    19
    Case: 14-11765       Date Filed: 05/17/2016   Page: 20 of 43
    deaths. It then sought the second superseding indictment, which was proper. See
    United States v. Cole, 
    755 F.2d 748
    , 757–58 (11th Cir. 1985) (explaining that
    additional, warranted charges may be brought against a defendant who declines to
    negotiate a lesser guilty plea).
    Castronuovo also fails to show actual vindictiveness because he has not
    proven that the government filed the second superseding indictment solely to
    penalize him. Castronuovo argues that once he expressed his intent to move for a
    severance, the government took six months to return the second superseding
    indictment when it initially stated that it would be returned in less than a month.
    But Castronuovo fails to show that the longer timeline was intentional or
    prejudicially affected his rights. Because Castronuovo has not shown that the
    government delayed solely to penalize him, the district court did not err in refusing
    to dismiss the second superseding indictment.
    2.       Prosecutorial misconduct
    Second, Castronuovo contends that the prosecutor’s improper questions and
    inflammatory comments during the grand jury process prejudiced his rights. “‘A
    prosecutor is . . . forbidden to make improper suggestions, insinuations and
    assertions calculated to mislead the jury’ and may not appeal to the jury’s passion
    or prejudice.” United States v. Rodriguez, 
    765 F.2d 1546
    , 1560 (11th Cir. 1985)
    (quoting United States v. Phillips, 
    664 F.2d 971
    , 1030 (5th Cir. Unit B 1981)).
    20
    Case: 14-11765     Date Filed: 05/17/2016   Page: 21 of 43
    “When the alleged prosecutorial misconduct occurs in the context of a grand jury
    proceeding, we dismiss the indictment only when the misconduct ‘substantially
    influenced the grand jury’s decision to indict’ or when there is ‘grave doubt that
    the decision to indict was free from the substantial influence of such violations.’”
    United States v. Cavallo, 
    790 F.3d 1202
    , 1219 (11th Cir. 2015) (quoting Bank of
    Nova Scotia v. United States, 
    487 U.S. 250
    , 256 (1988)).
    Here, Castronuovo identifies a number of troubling comments made by the
    prosecutor during the grand jury proceedings. For example, one juror asked about
    the two patient deaths. The juror asked if the deceased underwent MRI exams,
    stating that “the person could have given [Castronuovo] that information and
    typically, a physical exam without any cardio–.” But the prosecutor cut off the
    juror’s question. The prosecutor said, “If this was a real doctor. Again, the
    evidence has reflected that these were pill mill doctors that were there to spend the
    least amount of time possible.” The prosecutor further stated that the other doctors,
    who had admitted to drug dealing activity, would testify at trial “that they were
    drug dealers and they did the same thing these two did.”
    The prosecutor also asked one grand jury witness, Dr. Baden, whether he
    would “want to know if Dr. Castronuovo was a criminal or not” as a forensic
    pathologist expert that worked on the case. Dr. Baden answered that “I’m here to
    talk about how somebody died, not if he’s a criminal” and later stated that “unlike
    21
    Case: 14-11765     Date Filed: 05/17/2016   Page: 22 of 43
    television, the medical examiner is not an investigator.” But the prosecutor did not
    stop there. Instead, he asked the following: “Are you aware, sir, that this very
    grand jury indicted 32 people for running illegal pill mills, 28 of whom have pled
    guilty, are in prison right now, and also previously filed charges against Dr.
    Castronuovo?” Dr. Baden responded by saying he was “[v]aguely aware of it,” but
    that “[a]ll I’m dealing with are two deaths.”
    The prosecutor then asked Dr. Wright, another expert witness, if he had
    “ever been in Broward County Hospital to see the babies born addicted to
    Oxycodone?” The prosecutor stated that “in 2009, nearly 1,000 babies who were
    born in Florida hospitals were treated for drug withdrawal syndrome” and
    concluded that “[i]t’s fairly obvious that Dr. Castronuovo illegally prescribed these
    drugs. He was, in fact, just a drug dealer.”
    This conduct, when viewed in its totality, was more flagrant than a “few
    unwitting and inadvertent gestures by the prosecutor.” United States v. Pabian, 
    704 F.2d 1533
    , 1540 (11th Cir. 1983). But Castronuovo has not “established that the
    violation[s] substantially influenced the grand jury’s decision to indict” and the
    record does not establish “‘grave doubt’ that the decision to indict was free from
    the substantial influence of such violations.” Bank of Nova Scotia, 
    487 U.S. at
    256–57 (quoting United States v. Mechanik, 
    475 U.S. 66
    , 78 (1986) (O’Connor, J.,
    concurring)). The strength of the evidence on the drug and money laundering
    22
    Case: 14-11765        Date Filed: 05/17/2016   Page: 23 of 43
    conspiracies was significant. For example, the grand jurors were informed that the
    investigation required examination of patient files, wiretapped conversations,
    surveillance recordings, and autopsy reports. The jurors were also presented with
    statistics from a dispensing tracking system as to how many units of Oxycodone
    were ordered and/or received under Defendants’ dispensing licenses. And an FBI
    special agent testified that Cadet earned in excess of one million dollars, paid in
    cash and by check, from her prescribing activities, while Castronuovo earned over
    $100,000.
    Moreover, the petit jury, which did not hear the prosecutor’s remarks, found
    Castronuovo guilty for conspiracy to commit money laundering. See United States
    v. Flanders, 
    752 F.3d 1317
    , 1333 (11th Cir. 2014) (“Thus, the petit jury’s guilty
    verdicts demonstrate that there was probable cause to charge Defendants with the
    offenses for which they were convicted, and any alleged misconduct before the
    grand jury was harmless.”). Therefore, because Castronuovo has not identified any
    prejudiced he suffered as a result of the prosecutor’s conduct, the district court did
    not err in denying his motion to dismiss the indictment.
    C.      Motion to Suppress
    Castronuovo next argues that the district court erred in denying his motion to
    suppress his pre-indictment interview statements. Castronuovo avers that the
    district court should have granted his motion to suppress for two reasons: (1) his
    23
    Case: 14-11765     Date Filed: 05/17/2016    Page: 24 of 43
    statements were inadmissible as part of a plea agreement, and (2) his statements
    were procured as a result of his attorney’s ineffective assistance.
    First, Castronuovo argues that his statements were made as part of a plea
    agreement. Federal Rule of Criminal Procedure 11(f) provides that “[t]he
    admissibility or inadmissibility of a plea, a plea discussion, and any related
    statement is governed by Federal Rule of Evidence 410.” Fed. R. Crim. P. 11(f).
    Federal Rule of Evidence 410, in turn, provides that a court cannot admit against a
    defendant “a statement made during plea discussions with an attorney for the
    prosecuting authority if the discussions did not result in a guilty plea or they
    resulted in a later-withdrawn guilty plea.” Fed. R. Evid. 410 (a)(4).
    “To determine whether a discussion should be characterized as a plea
    negotiation, the trial court must determine, first, whether the accused exhibited an
    actual subjective expectation to negotiate a plea at the time of the discussion, and,
    second, whether the accused’s expectation was reasonable given the totality of the
    objective circumstances.” United States v. Merrill, 
    685 F.3d 1002
    , 1013 (11th Cir.
    2012) (citing United States v. Robertson, 
    582 F.2d 1356
    , 1366 (5th Cir. 1978)).
    The denial of a motion to suppress presents a mixed question of fact and
    law. United States v. Delancy, 
    502 F.3d 1297
    , 1304 (11th Cir. 2007). We review
    the findings of fact for clear error and the interpretation and application of law de
    novo. 
    Id.
     “[W]e may affirm the denial of a motion to suppress on any ground
    24
    Case: 14-11765    Date Filed: 05/17/2016   Page: 25 of 43
    supported by the record.” United States v. Caraballo, 
    595 F.3d 1214
    , 1222 (11th
    Cir. 2010).
    Here, the district court found that even if Castronuovo had a subjective
    expectation to negotiate a plea at the meetings with government agents, his
    expectation was objectively unreasonable. Before ruling on Castronuovo’s motion
    to suppress, the district court held a hearing with Castronuovo, his former attorney,
    and the agents who were present during the discussions. After hearing testimony,
    the court determined that an expectation of plea negotiations was objectively
    unreasonable where no charges against Castronuovo were pending and no
    discussions of potential charges or immunity occurred before or during the
    meetings. The government was still gathering evidence and interviewing witnesses
    as part of an ongoing investigation when the discussions occurred. These factual
    findings were not clearly erroneous, and the court properly concluded that even if
    Castronuovo expected to negotiate a plea during the meetings, the expectation was
    not objectively reasonable. See, e.g., Merrill, 685 F.3d at 1013 (“There were no
    pending charges against [the defendant] when the discussion occurred, and the
    general discussions of leniency did not transform [the defendant]’s meeting with
    the prosecutor and federal agents into plea negotiations.”). Therefore, the
    discussions should not have been characterized as a plea negotiation, and the
    district court properly denied Defendant’s motion to suppress.
    25
    Case: 14-11765     Date Filed: 05/17/2016    Page: 26 of 43
    Second, Castronuovo argues that the district court erred in denying his
    motion to suppress because his attorney at the time, Michelle Suskauer, Esquire,
    was ineffective for failing to secure limited use immunity before the interview. We
    have held that “[e]xcept in the rare instance when the record is sufficiently
    developed, we will not address claims for ineffective assistance of counsel on
    direct appeal.” United States v. Merrill, 
    513 F.3d 1293
    , 1308 (11th Cir. 2008)
    (alterations in original) (quoting United States v. Verbitskaya, 
    406 F.3d 1324
    , 1337
    (11th Cir. 2005)). Instead, “[t]he better-reasoned approach is to permit ineffective-
    assistance claims to be brought in the first instance in a timely motion in the
    district court under [28 U.S.C.] § 2255,” “even if the record contains some
    indication of deficiencies in counsel’s performance.” Massaro v. United States, 
    538 U.S. 500
    , 504 (2003). Here, although the district court held an evidentiary hearing
    in connection with Castronuovo’s motion to suppress, the basis for Ms. Suskauer’s
    recommendation that Castronuovo participate in the meetings and the actions taken
    by Ms. Suskauer to investigate the case against Castronuovo up to that point are
    not sufficiently developed. Thus, Castronuovo’s ineffective assistance claim would
    be more appropriately addressed in a motion under 
    28 U.S.C. § 2255
    .
    D.    Prejudicial Joinder
    Castronuovo next argues that the district court erred in denying his motion
    for relief from prejudicial joinder because he was irreparably prejudiced by the
    26
    Case: 14-11765     Date Filed: 05/17/2016    Page: 27 of 43
    jury hearing evidence against both Defendants in the same trial. But Castronuovo
    cannot demonstrate that the district court abused its discretion.
    Generally, defendants who are indicted together are tried together unless the
    defendant seeking severance can show that a joint trial would prejudice his
    substantial rights and that “severance is the only proper remedy for that prejudice.”
    United States v. Lopez, 
    649 F.3d 1222
    , 1234 (11th Cir. 2011); see Fed. R. Crim. P.
    14(a) (stating that “the court may order separate trials of counts, sever the
    defendants’ trials, or provide any other relief that justice requires” where the
    joinder of offenses or defendants “appears to prejudice a defendant or the
    government”). And we have expressed our “reluctan[ce] to reverse a district
    court’s denial of severance, particularly in conspiracy cases.” United States v.
    Knowles, 
    66 F.3d 1146
    , 1158 (11th Cir. 1995).
    In deciding a severance motion, a district court must balance the right of the
    defendant to a fair trial against the public’s interest in efficient and economic
    administration of justice. United States v. Alvarez, 
    755 F.2d 830
    , 857 (11th Cir.
    1985). Severance is granted only when the defendant can demonstrate that a joint
    trial will result in “specific and compelling prejudice” to his defense, 
    id.
     (quoting
    United States v. Zielie, 
    734 F.2d 1447
    , 1464 (11th Cir. 1984)), resulting in
    “fundamental unfairness.” Knowles, 
    66 F.3d at 1159
    .
    27
    Case: 14-11765      Date Filed: 05/17/2016    Page: 28 of 43
    There are four instances of prejudicial joinder that will generally require
    severance: where (1) “the [d]efendants rely on mutually antagonistic defenses”;
    (2) “one [d]efendant would exculpate the moving [d]efendant in a separate trial,
    but will not testify in a joint setting”; (3) “inculpatory evidence will be admitted
    against one [d]efendant that is not admissible against the other”; and (4) “a
    cumulative and prejudicial ‘spill over’ effect may prevent the jury from sifting
    through the evidence to make an individualized determination as to each
    [d]efendant.” United States v. Chavez, 
    584 F.3d 1354
    , 1360–61 (11th Cir. 2009).
    Demonstrating one of these four instances is a “heavy burden.” Kennard, 
    472 F.3d at
    858–59.
    Here, Defendants were jointly indicted for the same conspiracy based on
    their acts at sister clinics. Defendants did not rely on mutually antagonistic
    defenses, and neither Defendant contends that he or she would have testified
    against the other in the event of separate trials. There is no indication that the
    government intended to use inculpatory evidence that was admissible against
    Cadet but not admissible against Castronuovo. And Castronuovo did not identify
    any cumulative or prejudicial spillover effect that would have prevented the jury
    from sifting through the evidence to make an individualized determination as to
    each Defendant.
    28
    Case: 14-11765      Date Filed: 05/17/2016    Page: 29 of 43
    Moreover, the district court instructed the jury to consider the case of each
    defendant separately and individually. See Kennard, 
    472 F.3d at 859
     (explaining
    that “the potential ‘spillover effect’ of evidence of a co-defendant’s guilt” is
    generally “mitigate[d]” by “a court’s cautionary instructions”). Thus, because a
    joint trial did not prejudice Castronuovo, the district court did not abuse its
    discretion in denying his severance motion.
    E.     Allen Charge
    Castronuovo’s final argument on appeal is that the district court improperly
    coerced the jury by effectively delivering two modified Allen charges. “An ‘Allen
    charge’ is a trial court’s admonition to a deadlocked jury, instructing it to make
    further attempts to reach a verdict.” United States v. Polar, 
    369 F.3d 1248
    , 1254
    (11th Cir. 2004). A district court abuses its discretion by giving an Allen charge
    only if it was “inherently coercive.” Woodard, 
    531 F.3d at 1364
    . To determine
    whether the charge was inherently coercive, we consider the language used and the
    totality of the circumstances surrounding the charge, including whether the district
    court polled the jury before giving the charge and the amount of time that elapsed
    between the charge and the verdict’s return. 
    Id.
    There was no sign of coercion here. The district court had not polled the
    jurors before issuing the Allen charge, and the 2 to 2 ½ hours that elapsed between
    the charge and the returned verdict does not suggest coercion. See United States v.
    29
    Case: 14-11765     Date Filed: 05/17/2016    Page: 30 of 43
    Chigbo, 
    38 F.3d 543
    , 546 (11th Cir. 1994) (concluding after the jury returned a
    verdict within fifteen minutes of delivery of the charge that “[t]he speed with
    which the jury returned its verdict after receiving the modified Allen charge does
    not change our decision”); see also United States v. Jones, 518 F. App’x 741, 743
    (11th Cir. 2013) (nonprecedential) (Allen charge not coercive where jury returned
    a verdict roughly thirty minutes later); United States v. Miller, 451 F. App’x 896,
    898 (11th Cir. 2012) (nonprecedential) (Allen charge not coercive where jury
    returned a verdict about eight minutes later). Moreover, the district court’s charge
    was based on language from the Eleventh Circuit Pattern Jury Instruction for
    deadlocked juries, which we have held to be non-coercive. United States v.
    Trujillo, 
    146 F.3d 838
    , 846–47 (11th Cir. 1998).
    Castronuovo nevertheless argues that the circumstances surrounding the
    charge were unduly coercive because the district court’s directions to completely
    fill out the verdict form constituted the “first,” constructive Allen charge, followed
    by a “second,” official Allen charge when the jury reported that it was deadlocked.
    But this argument holds no water.
    In giving an Allen charge, the district court instructs a deadlocked jury to
    undertake further efforts to reach a verdict. Polar, 
    369 F.3d at 1254
    . Here, the jury
    had not indicated that it was deadlocked when the court instructed the jury to fill
    out the blank portions of the verdict sheet. Rather, the jury sent a note indicating
    30
    Case: 14-11765     Date Filed: 05/17/2016   Page: 31 of 43
    they had reached a verdict before it submitted the incomplete verdict forms. Thus,
    the district court’s subsequent instruction to fill out the form completely was not a
    “constructive” Allen charge. Instead, the district court gave a single modified Allen
    charge after the jury stated that it was deadlocked, which was proper. Because no
    facts indicate that the Allen charge was inherently coercive, the district court did
    not abuse its discretion by issuing it.
    F.     Cumulative Prejudicial Effect
    Cadet further argues that she should be granted a new trial based on the
    cumulative error doctrine. Although Cadet suggests that any one of the alleged
    errors is sufficient to warrant a new trial, Cadet argues that their combined effect
    rendered her trial fundamentally unfair.
    Under the cumulative error doctrine, the “cumulative prejudicial effect of
    many errors may be greater than the sum of the prejudice caused by each
    individual error” in a manner that denies a defendant of a fair trial. United States v.
    Baker, 
    432 F.3d 1189
    , 1223 (11th Cir. 2005), abrogated on other grounds by Davis
    v. Washington, 
    547 U.S. 813
    , 821 (2006). “We address claims of cumulative error
    by first considering the validity of each claim individually, and then examining any
    errors that we find in the aggregate and in light of the trial as a whole to determine
    whether the appellant was afforded a fundamentally fair trial.” Morris v. Sec’y,
    Dep’t of Corr., 
    677 F.3d 1117
    , 1132 (11th Cir. 2012). We will reverse a conviction
    31
    Case: 14-11765    Date Filed: 05/17/2016    Page: 32 of 43
    only if the defendant can show that the aggregate of nonreversible errors affected
    his substantial rights. United States v. Capers, 
    708 F.3d 1286
    , 1299 (11th Cir.
    2013).
    1.    Constructive amendment of the indictment
    Cadet4 first contends that the district court constructively amended the
    indictment by giving a jury instruction that altered the specified unlawful activity
    underlying the money laundering conspiracy count. A constructive amendment
    occurs when “the prosecutor’s actions or the court’s instructions, ‘viewed in
    context,’ resulted in the expansion of an indictment either literally or in effect.”
    United States v. Behety, 
    32 F.3d 503
    , 508–09 (11th Cir. 1994) (quoting United
    States v. Andrews, 
    850 F.2d 1557
    , 1559 (11th Cir. 1988) (en banc)). The “essential
    elements of an indictment are impermissibly broadened when an indictment
    includes language describing the statutory crime and additional language
    narrowing the charged crime to a subset of the statutory crime, but the jury
    instruction omits the narrowing language.” United States v. Moore, 
    525 F.3d 1033
    ,
    1045 (11th Cir. 2008) (citing United States v. Narog, 
    372 F.3d 1243
    , 1248 (11th
    Cir. 2004)).
    The statutory offense for a § 1957(a) money laundering conspiracy requires
    that a defendant “knowingly engage[] or attempt[] to engage in a monetary
    4
    Castronuovo adopts this argument.
    32
    Case: 14-11765     Date Filed: 05/17/2016    Page: 33 of 43
    transaction in criminally derived property of a value greater than $10,000” that “is
    derived from specified unlawful activity.” 
    18 U.S.C. § 1957
    (a). The second
    superseding indictment included language narrowing the charged crime by stating
    that “the specified unlawful activity is the distribution, dispensing and possession
    with intent to distribute and dispense[] oxycodone, a Schedule II narcotic
    controlled substance” that was “outside the scope of professional practice and not
    for a legitimate medical purpose.”
    But the jury instructions did not include the indictment’s narrowing
    language. The instructions did not specify that the distribution must be “outside the
    scope of professional practice and not for a legitimate purpose” and that the
    controlled substance must be “Oxycodone.” They stated only that the criminal
    source of the proceeds must be the “felonious” distribution of a “controlled
    substance.” By omitting the narrowing language, the instruction constructively
    amended the indictment. Narog, 
    372 F.3d at 1248
    .
    A jury instruction that constructively amends an indictment constitutes
    reversible error per se if the defendant objected to the jury instruction before the
    jury retired to deliberate. Madden, 733 F.3d at 1321 n.5. Cadet argues that she
    preserved the issue in a post-trial motion to vacate her conviction wherein she
    stated that the district court “deliberate[ly]” omitted the language “due to Defense
    counsels’ specific requests to mirror the definition from the Indictment.” But Cadet
    33
    Case: 14-11765      Date Filed: 05/17/2016    Page: 34 of 43
    did not object to the instruction before the jury retired to deliberate, so the
    constructive amendment is not reversible error per se.
    Instead, we review the district court’s instruction for plain error. Gutierrez,
    745 F.3d at 471; Madden, 733 F.3d at 1321 n.5. Reversal is warranted only if the
    constructive amendment (1) was plain, (2) affected Defendants’ substantial rights,
    and (3) seriously affected the fairness, integrity, and public reputation of judicial
    proceedings. United States v. Romano, 
    314 F.3d 1279
    , 1281–82 (11th Cir. 2002).
    Here, even though the jury instruction constructively amended the
    indictment, the constructive amendment did not affect Defendants’ substantial
    rights because the indictment’s substance remained intact. See Moore, 
    525 F.3d at 1046
    . The district court instructed the jury that Defendants were charged in Count
    1 with a conspiracy to “to distribute, dispense or possess with intent to distribute or
    dispense Oxycodone without authorization by law” and that “Section 841(a)(1)
    makes it a crime for anyone to knowingly distribute, dispense or possess with the
    intent to distribute or dispense Oxycodone.” Only Counts 3 and 4, relating to the
    drug-related patient deaths, mentioned another controlled substance (i.e.,
    Alprazolam, which is also known as Xanax). Evidence at trial focused on
    Oxycodone as well. See United States v. Cromartie, 
    267 F.3d 1293
    , 1296–97 (11th
    Cir. 2001) (failure to submit required element to jury was not reversible plain error
    because the jury “necessarily” relied on “[t]he only evidence” at issue establishing
    34
    Case: 14-11765     Date Filed: 05/17/2016    Page: 35 of 43
    the requisite element). And while the district court’s instructions referred to
    Oxycodone on eight separate occasions, Alprazolam was mentioned just once.
    The district court also instructed the jury that for Counts 3 through 11 the
    government must prove beyond a reasonable doubt that “[t]he Defendant
    distributed or dispensed, or possessed with intent to distribute or dispense, not for a
    legitimate medical purpose or outside the usual course of professional practice, the
    controlled substance as charged.” The court even reminded the jurors that “[a]gain,
    Defendants are charged with knowingly and willfully prescribing controlled
    substances to his or her patients outside the usual course of professional medical
    practice.” Moreover, based on the evidence presented at trial and because
    Defendants were physicians with dispensing licenses, the only way that the
    “buying, selling, and otherwise dealing in a controlled substance” at the clinics
    could have been “felonious” for the purposes of Defendants’ conviction was if
    those actions were taken “outside the scope of professional practice and not for a
    legitimate purpose.”
    So although the instructions for Count 13 did not specify the controlled
    substance or restate how the distribution was “felonious,” no rational jury would
    have convicted Defendants for money laundering conspiracy without considering
    the proceeds to be derived from Oxycodone that was dispensed “outside the scope
    of professional practice.” Thus, in light of the instructions as a whole and the
    35
    Case: 14-11765        Date Filed: 05/17/2016    Page: 36 of 43
    evidence shown at trial, Defendants’ substantial rights were not affected by the
    instruction, and a new trial is not warranted.
    2.      Guilt by association
    As to the second error alleged in her cumulative error argument, Cadet 5
    contends that the prosecutor’s theory of guilt by association prejudiced her rights.
    During opening statements, the prosecutor repeatedly referred to the “criminal
    doctors” as a collective. The prosecutor stated that the jury would know Cadet’s
    guilt when other doctors “come in in their prison jumpsuit[s]” and tell the jury
    “what they did.” And the prosecutor referred to the witnesses’ “prison jumpsuits”
    on at least two other occasions. He further stated that these witnesses would “say
    they saw the same patients as Defendant Cadet and Defendant Castronuovo, and
    when they wrote those prescriptions, those criminal doctors, they were criminals,
    they were drug dealers, they did it without a medical purpose and it was outside the
    scope of their practice.” The prosecutor concluded that these were “the same
    prescriptions written by Cadet and Castronuovo.” Defendants generally objected to
    these statements.
    Also, during closing argument, the prosecutor continually referred to the
    other doctors appearing “in handcuffs and leg irons.” The prosecutor posed the
    following hypothetical to the jury: “So how can Dr. Cadet reasonably distinguish
    5
    Castronuovo adopts this argument.
    36
    Case: 14-11765       Date Filed: 05/17/2016      Page: 37 of 43
    herself and her practices from those of Drs. Aruta, Boshers, and Dreszer?” The
    prosecutor suggested that “the answer is she can’t.” Defendants did not object to
    the prosecutor’s closing argument.
    We review a claim of prosecutorial misconduct de novo. United States v.
    House, 
    684 F.3d 1173
    , 1197 (11th Cir. 2012). But where the defendant does not
    object to the propriety of the prosecutor’s statement, we review for plain error
    only. Flanders, 752 F.3d at 1332–33. Under plain error review, “the defendant
    must show that (1) an error occurred; (2) the error was plain; (3) it affected his
    substantial rights; and (4) it seriously affected the fairness of the judicial
    proceedings.” Id.
    Here, under either standard, the prosecutor’s comments do not warrant a new
    trial. It is well understood that “[o]ne person’s guilty plea or conviction may not be
    used as substantive evidence of the guilt of another.” United States v. King, 
    505 F.2d 602
    , 607 (5th Cir. 1974). 6 But the prosecutor may comment on the evidence
    presented to the jury when describing the close association between
    co-conspirators. See United States v. Castro, 
    89 F.3d 1443
    , 1457 (11th Cir. 1996)
    (describing the appellants’ guilt-by-association argument as “meritless” because
    “the prosecutor properly commented on the evidence presented to the jury when he
    6
    In Bonner v. City of Prichard, 
    661 F.2d 1206
    , 1209 (11th Cir. 1981) (en banc), this court
    adopted as binding precedent all decisions of the former Fifth Circuit handed down prior to
    October 1, 1981.
    37
    Case: 14-11765     Date Filed: 05/17/2016    Page: 38 of 43
    described the close association that appellants shared with others involved in the
    kickback scheme prior to and during their criminal activities”); United States v.
    Tisdale, 
    817 F.2d 1552
    , 1555 (11th Cir. 1987) (explaining that no error occurs
    when the evidence supports a prosecutor’s comments). And the prosecutor may
    “blunt the impact of ‘expected attacks on witnesses’ credibility’” by “disclos[ing]
    guilty pleas of Government witnesses.” United States v. DeLoach, 
    34 F.3d 1001
    ,
    1004 (11th Cir. 1994) (quoting United States v. Countryman, 
    758 F.2d 574
    , 577
    (11th Cir. 1985)). There was no reversible error when the prosecutor commented
    on witnesses appearing in their “prison jumpsuits,” a fact observable by the jurors
    themselves. See, e.g., United States v. Adams, 
    1 F.3d 1566
    , 1584 (11th Cir. 1993).
    Moreover, the district court’s curative instructions mitigated the impact of
    the prosecutor’s comments. The district court told the jury to consider the
    testimony of pleading witnesses “with more caution” and stated that those
    witnesses may “hope to gain more favorable treatment.” The district court also
    explained that “the fact that a witness has pleaded guilty to an offense isn’t
    evidence of the guilt of any other person,” and it reminded the jury that “anything
    the lawyers say is not evidence.” These cautionary instructions “sufficiently cure
    any potential for prejudice to the defendant on trial.” United States v. Carrazana,
    
    921 F.2d 1557
    , 1568 (11th Cir. 1991). As such, the prosecutor’s comments do not
    warrant a new trial.
    38
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    3.       Cross-examination
    Cadet next challenges the district court’s limitation on cross-examination of
    Chris George about his tattoo of a Nazi symbol, a picture in which he saluted a
    Nazi flag, and his use of the “N word.” Cadet argues that the district court abused
    its discretion in limiting cross-examination pursuant to Federal Rule of Evidence
    403 and that this limitation violated Cadet’s Confrontation Clause rights under the
    Sixth Amendment.
    First, under Rule 403, the district court may exclude otherwise relevant
    evidence if “its probative value is substantially outweighed by the danger of unfair
    prejudice.” Fed. R. Evid. 403. When reviewing a district court’s Rule 403
    evidentiary ruling, “we look at the evidence in a light most favorable to its
    admission, maximizing its probative value and minimizing its undue prejudicial
    impact.” United States v. Brown, 
    441 F.3d 1330
    , 1362 (11th Cir. 2006).
    Here, the district court determined that the evidence had minimal probative
    value as to bias because the record indicated that George had a good relationship
    with Cadet, untainted by racial bias. The minimal probative value was substantially
    outweighed by the unfair prejudice that would result from its use. Cadet, therefore,
    has not shown that the district court abused its discretion.
    Moreover, Cadet has not shown that the district court’s decision impeded her
    ability to otherwise effectively cross-examine George. Cadet extensively cross-
    39
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    examined George about the ways in which he surreptitiously operated the clinics
    and kept Cadet shielded from certain aspects of the clinics’ scheme. Cadet also
    asked George about his plea agreement with the government, which required him
    to testify if called upon. There was ample evidence upon which Cadet could and
    did argue that George’s testimony was unreliable and upon which the jury could
    evaluate George’s credibility.
    Second, the limitation on cross-examination did not violate Cadet’s Sixth
    Amendment rights. A defendant “is entitled only to an opportunity for effective
    cross-examination, not cross-examination that is effective in whatever way, and to
    whatever extent, the defendant might wish.” Maxwell, 
    579 F.3d at 1296
     (quoting
    United States v. Baptista-Rodriguez, 
    17 F.3d 1354
    , 1366 (11th Cir. 1994)). District
    courts “retain wide latitude” to reasonably limit “cross-examination based on
    concerns about, among other things, harassment, prejudice, confusion of the issues,
    the witness’ safety, or interrogation that is repetitive or only marginally relevant.”
    Delaware v. Van Arsdall, 
    475 U.S. 673
    , 679 (1986). “The test for the
    Confrontation Clause is whether a reasonable jury would have received a
    significantly different impression of a witness’ credibility had counsel pursued the
    proposed line of cross-examination.” United States v. Garcia, 
    13 F.3d 1464
    , 1469
    (11th Cir. 1994).
    40
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    Under these circumstances, we cannot say that a reasonable jury would have
    received a significantly different impression of George’s credibility had the district
    court allowed the proposed line of questioning. Although the importance of cross-
    examining George was heightened because he spearheaded the clinics’ operations,
    Defendants’ counsel had ample opportunity to raise doubts about George’s
    credibility and did so. Permitting cross-examination about his tattoo, photo, and
    racial slurs would not have provided a significantly different impression of his
    credibility. Thus, the Confrontation Clause was satisfied, and the district court did
    not abuse its discretion in limiting cross-examination.
    4.       Good faith defense
    Finally, Cadet argues that the district court erroneously instructed the jury
    that a good faith defense applies to the substantive drug conspiracy count, but not
    the money laundering conspiracy count. Yet Cadet requested a good faith
    instruction only for the drug conspiracy count. And she did not otherwise object to
    the instruction’s absence during the charge conference. Thus, we review for plain
    error the district court’s failure to give the good faith instruction as to the money
    laundering conspiracy count. Pena, 684 F.3d at 1151.
    “Under the plain error standard, an appellant must show that: (1) an error
    occurred; (2) the error was plain; (3) it affected his substantial rights; and (4) it
    seriously affected the fairness of the judicial proceedings.” Id. The defendant
    41
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    “bears the burden of persuasion” as to the third prong and “must show that the
    claimed error affected his substantial rights, which almost always requires that the
    error must have affected the outcome of the district court proceedings.” Id.
    (quoting United States v. Pantle, 
    637 F.3d 1172
    , 1177 (11th Cir. 2011) (per
    curiam)). Where the instructions “adequately informed the jury’s good faith
    analysis,” there is “no reversible error leaving a substantial, ineradicable doubt as
    to whether the court’s instructions properly guided the jury’s deliberations.”
    Dohan, 
    508 F.3d at 993
    .
    Here, the district court instructed the jury that it must find, inter alia, that
    (1) Defendants “knew the transaction involved property or funds that were the
    proceeds of some criminal activity”; (2) “the individual Defendant knew that the
    property involved in the monetary transaction was obtained or derived from
    committing some crime”; and (3) “the individual Defendant knew about the plan’s
    unlawful purpose and willfully joined in it.” These instructions required the jury to
    rule out the possibility that Cadet actually harbored a good faith belief in the
    legitimacy of the clinics’ business before it could have found that she knew that the
    money represented criminally derived proceeds. Thus, because the charges as a
    whole adequately informed the jury’s good faith analysis, the district court did not
    commit reversible error.
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    Consequently, Cadet has not presented any individually reversible error, so
    no cumulative prejudicial effect warrants a new trial.
    IV. CONCLUSION
    We AFFIRM Defendants’ judgments of conviction.
    43