United States v. Donatus Iriele ( 2020 )


Menu:
  •          USCA11 Case: 17-13455      Date Filed: 10/09/2020   Page: 1 of 55
    [PUBLISH]
    IN THE UNITED STATES COURT OF APPEALS
    FOR THE ELEVENTH CIRCUIT
    ________________________
    No. 17-13455
    ________________________
    D.C. Docket No. 1:12-cr-00276-SCJ-JKL-6
    UNITED STATES OF AMERICA,
    Plaintiff-Appellee,
    versus
    DONATUS IRIELE,
    Defendant-Appellant.
    ________________________
    Appeal from the United States District Court
    for the Northern District of Georgia
    ________________________
    (October 9, 2020)
    Before BRANCH, TJOFLAT, and ED CARNES, Circuit Judges.
    ED CARNES, Circuit Judge:
    For pill pushers and drug addicts, one part of Lakewood Avenue in south
    Atlanta offered one-stop shopping. There was a pill mill where they could get
    USCA11 Case: 17-13455            Date Filed: 10/09/2020        Page: 2 of 55
    prescriptions for their controlled substances of choice with few, if any, questions
    asked. And only a short walk down the street was a pharmacy that would fill those
    prescriptions even if there were red flags galore. The pill mill was the Atlanta
    Medical & Research Clinic (AMARC) and the compliant pharmacy was the
    Medicine Center Pharmacy (MCP).1 Donatus Iriele and his wife, Rosemary
    Ofume, ran that pharmacy. Both were indicted on various charges.
    A jury found Iriele guilty of conspiring with AMARC’s owners and doctors
    to illegally dispense controlled substances, of aiding and abetting the illegal
    dispensing of controlled substances, and of laundering and conspiring to launder
    the proceeds of those illicit sales. This is Iriele’s appeal.
    Ofume was convicted for many of the same crimes but she has since died.
    As a result, we entered an order dismissing Ofume’s part of the appeal as moot and
    remanding that part for the district court to vacate her convictions and dismiss the
    indictment as to her. See United States v. Koblan, 
    478 F.3d 1324
    , 1325 (11th Cir.
    1
    The parties use that acronym for the clinic and that initialism for the pharmacy and so
    will we. We recognize that the use of these two types of abbreviations is not universally
    applauded. See, e.g., Notice of the U.S. Court of Appeals for the D.C. Circuit (January 26, 2010)
    (“To enhance the clarity of the brief, the court strongly urges parties to limit the use of acronyms.
    While acronyms may be used for entities and statutes with widely recognized initials, such as
    FERC and FOIA, parties should avoid using acronyms that are not widely known.”); Bryan A.
    Garner, Legal Writing in Plain English 60–62 (2d ed. 2013) (advising legal writers to “[s]hun
    newfangled acronyms”). We use AMARC and MCP in this opinion because doing so nets out on
    the side of clarity and helps keep the opinion flowing. Besides, the acronym AMARC “does
    have a nice ring to it.” See Dormescar v. U.S. Att’y Gen., 
    690 F.3d 1258
    , 1259 n.2 (11th Cir.
    2012).
    2
    USCA11 Case: 17-13455       Date Filed: 10/09/2020    Page: 3 of 55
    2007). Our order provided that the appeal would “continue unabated” as to Iriele,
    and so it has.
    I. FACTUAL BACKGROUND
    A. The Pill Mill
    Although this case is about Iriele and Ofume’s pharmacy, the story starts
    with AMARC. It was a pain management clinic owned and operated by Godfrey
    and Bona Ilonzo. The clinic had multiple locations throughout Georgia, but the
    one at issue here was located in Lakewood, a low-income neighborhood in Atlanta.
    AMARC operated out of an old house surrounded by a barbed wire fence. It had
    only two exam rooms and little medical equipment.
    Patients and employees described the clinic as small, dirty, rundown, and
    “sketchy.” A witness testified that at one appointment, there were “roaches
    crawling across the exam table.” Another witness testified that the clinic had
    “[h]oles in the floor, doors that didn’t close all the way, bugs, roaches, [and]
    broken chairs.” The sign out front described it as a clinic for “urgent care, family
    medicine, internal medicine, adults, women, [and] children,” but did not mention
    pain management.
    AMARC didn’t operate like a normal clinic or medical facility. Instead of
    allowing patients to schedule appointments, employees would call patients once a
    month and tell them what day they could come in to see a doctor. When patients
    3
    USCA11 Case: 17-13455         Date Filed: 10/09/2020      Page: 4 of 55
    arrived, they had to put their names on a sign-in sheet and would be seen on a first-
    come, first-served basis. As a result, patients often showed up hours before the
    clinic opened and waited in line in the parking lot. One patient said there was a
    “rat race” to be the first person seen. Eventually the clinic hired a security guard to
    see that people waited in their cars instead of congregating in front of the building.
    One doctor worked per shift, and he or she would normally arrive around
    11:00 a.m. but sometimes much later. The doctor would see between 40 and 100
    patients per day, sometimes causing the clinic to stay open until 10:00 or 11:00
    p.m. Physical exams lasted between five and ten minutes and often included
    nothing more than a basic vitals check, a quick evaluation of whatever area of the
    body the patient claimed was hurting, and a urine test for drugs. After the
    examination, the doctor would write one or more prescriptions. At least one
    AMARC doctor would often write prescriptions for patients without ever
    examining them at all.
    In almost all cases, AMARC would prescribe its patients opioids, Xanax, or
    Soma (a muscle relaxant). Usually the clinic would prescribe all three of those
    drugs to the same patient at the same time. 2 The doctors often gave patients
    prescriptions for the specific drugs that they asked for by name. The clinic did not
    2
    Soma was not a controlled substance when Iriele committed his crimes, but it is now.
    We mention it because opioids, Xanax, and Soma, when used in combination, are what one
    expert witness called the “the unholy holy trinity for substance abuse.”
    4
    USCA11 Case: 17-13455    Date Filed: 10/09/2020   Page: 5 of 55
    accept insurance, credit cards, debit cards, or money orders for doctor visits; it was
    cash only. First-time patients paid between $300 and $350 for their visit, while
    returning patients paid $150. Some long-time patients of the clinic paid only $100
    per visit.
    Former patients and clinic employees testified that most of AMARC’s
    clientele was made up of drug addicts and drug dealers, many of whom traveled
    from far away and in groups to visit the clinic. Witnesses recalled seeing patients
    who were underweight, had track marks on their arms, were missing teeth, had lost
    their hair, and were otherwise “disheveled” and “shaggy.” Witnesses also
    described how patients showed up “high” and would fall asleep, exchange
    medications, and shoot up drugs in the bathroom while waiting to see a doctor.
    One witness described AMARC’s patients as “living and talking and wanting and
    breathing for one thing”: pills.
    B. The Compliant Pharmacy
    Iriele and Ofume’s pharmacy, MCP, was located just a few blocks away
    from AMARC, an easy walk. Whenever MCP was open either Iriele or Ofume
    was present. Ofume was the main pharmacist, although others worked there.
    Iriele had been a licensed pharmacist but was no more. The Georgia Pharmacy
    5
    USCA11 Case: 17-13455        Date Filed: 10/09/2020    Page: 6 of 55
    Board had revoked his license in 2007 after he was caught filling forged
    prescriptions at a different pharmacy he owned.3
    There is some evidence that the absence of a license did not always keep
    Iriele from filling prescriptions. Although MCP’s former pharmacy technician
    testified that Iriele did paperwork and rang up customers instead of filling
    prescriptions, two former MCP customers testified that Iriele filled their
    prescriptions. Another witness testified that Iriele was “oftentimes” alone in the
    pharmacy.
    Like AMARC, MCP was small, dirty, and “rundown.” Customers testified
    that there were hardly any products on the shelves and that the few that were there
    were dusty and out of date. And like AMARC, MCP was a cash only
    establishment — at least when it came to filling prescriptions for controlled
    substances. No insurance accepted, only cash. According to several former
    customers, MCP charged a much higher price for opioids in particular than other
    pharmacies did. Yet, testing the laws of economics, the higher prices apparently
    didn’t dampen demand for what MCP was offering.
    MCP purchased (and hence sold) a lot more opioids than other pharmacies
    in the area. According to a data analyst who testified at trial, MCP was the top
    3
    The Georgia Pharmacy Board had also suspended Ofume’s pharmacy license for six
    months after concluding that she was filling forged prescriptions at MCP.
    6
    USCA11 Case: 17-13455       Date Filed: 10/09/2020   Page: 7 of 55
    purchaser of oxycodone in its zip code, far outpacing the other pharmacies in that
    area. For example, in 2010 MCP purchased 13 times more oxycodone pills
    (657,900) than a nearby Walgreens (48,600). In 2011 MCP purchased seven times
    more oxycodone pills (500,800) than a nearby Kroger pharmacy (69,800). MCP’s
    volume of opioid purchases also ranked high on a statewide basis. One witness
    presented charts showing the ten pharmacies that had purchased the most
    oxycodone in the State of Georgia for the years 2009 through 2012. For three of
    those four years, MCP was among the top ten. And for one of those years (2010) it
    reached the pill purchasing pinnacle, buying more oxycodone than any other
    pharmacy in the State of Georgia.
    C. The Connection Between the Pill Mill and the Compliant Pharmacy
    The vast majority of the prescriptions that MCP filled came from AMARC.
    Between 2009 and 2012, when the authorities shut down AMARC, MCP filled
    thousands of prescriptions from it. Those prescriptions accounted for 83% of those
    that MCP filled and made up more than 90% of the pharmacy’s gross sales. One
    former customer testified that there was usually a “line of patients” going from
    AMARC to MCP.
    It was no coincidence that most of MCP’s prescriptions came from
    AMARC. The clinic’s doctors and office employees often referred patients to
    MCP to have their prescriptions filled. This happened with increasing frequency
    7
    USCA11 Case: 17-13455       Date Filed: 10/09/2020   Page: 8 of 55
    as other pharmacies in the area began refusing to fill prescriptions written by
    AMARC’s doctors. According to AMARC’s patients, clinic employees told them
    that they could “go right across the street and fill with[ ] no problem.” An
    AMARC doctor testified that one of the clinic’s owners had told her “Rosemary
    [Ofume] will fill all of our prescriptions.”
    AMARC and MCP were often in contact with each other about their
    businesses. For example, Ofume would regularly call AMARC to let the doctors
    know that MCP had run out of a particular drug so that the clinic could prescribe
    one that the pharmacy had in stock. At one point, an AMARC doctor discovered
    that a clinic employee was issuing forged prescriptions in the doctor’s name.
    AMARC’s owners called Ofume and asked her to help them discourage that doctor
    from reporting the crime to the police. Ofume not only agreed but went to the
    clinic to talk with the doctor in person. Another time, the owners of AMARC
    spoke with Ofume about the possibility of them opening a new clinic in Alabama
    and her opening a new pharmacy close by.
    The owners and employees of both establishments were friendly with each
    other. The owners of AMARC would come into MCP on occasion to chat with
    Iriele, Ofume, and pharmacy employees. At least once Ofume was seen in the
    private area behind AMARC where the clinic’s doctors parked their cars. And
    8
    USCA11 Case: 17-13455        Date Filed: 10/09/2020    Page: 9 of 55
    Ofume had the personal cell phone number of one of the AMARC doctors in her
    address book.
    The owners and employees of the two establishments also did favors for
    each other. MCP employees who wanted to see a doctor at AMARC did not have
    to make an appointment or wait in line, and they often did not have to pay for the
    visit. Likewise, when AMARC employees wanted to get a prescription filled at
    MCP, the pharmacy often gave them a discount or did not charge them at all. And
    when AMARC employees wanted to fill a prescription for controlled substances,
    MCP let them use insurance — something that it refused to allow ordinary
    customers to do.
    The working relationship between AMARC and MCP was plain enough that
    many of AMARC’s patients and MCP’s customers assumed the two
    establishments were connected. A former AMARC patient and MCP customer
    testified that the word among the patients was that the clinic and pharmacy “were
    in business together.” He said it seemed “like it was a monopoly” because “you’ve
    got the doctor setting the price and . . . you’ve got the pharmacist that the doctor’s
    telling you to go to and they’re setting the price at what they want to.” Another
    AMARC patient and MCP customer testified that although she never heard “from
    the horse’s mouth” that the two establishments were connected, it was “hard not to
    9
    USCA11 Case: 17-13455         Date Filed: 10/09/2020      Page: 10 of 55
    tell” that they were. Other patients thought that one of AMARC’s owners and
    Ofume were sisters.
    D. The Undercover Visits
    The Drug Enforcement Agency eventually caught on to AMARC and MCP
    and began investigating. Between late 2010 and early 2011, undercover agent
    Chris Crutchfield conducted six undercover visits to AMARC and five undercover
    visits to MCP. During four of those visits an AMARC doctor prescribed
    Crutchfield controlled substances and MCP filled the prescriptions. 4 During two
    of his visits to MCP, Crutchfield in front of Ofume offered to purchase other
    customers’ controlled substances. Ofume never said anything to Crutchfield about
    it, and at one point she laughed about it. On one of those occasions, three other
    customers took Crutchfield up on his offers to purchase controlled substances from
    them. Crutchfield recalled seeing Iriele during only one of his trips to MCP, but he
    could not remember which trip it was.
    In August 2012, the authorities shut down AMARC and MCP. By that time,
    though, MCP was already having difficulty getting drug distributors to sell it
    controlled substances.
    4
    Crutchfield was unable to see a doctor at AMARC during his first visit there, but an
    agent accompanying him did see a doctor who gave the agent a prescription. Both agents then
    went to MCP together, and it filled the prescription.
    10
    USCA11 Case: 17-13455         Date Filed: 10/09/2020       Page: 11 of 55
    II. PROCEDURAL HISTORY
    In September 2013, a grand jury named Iriele and several other defendants
    in a 28-count indictment.5 He was charged in 10 of those counts. Count 1 charged
    Iriele with conspiring to distribute and dispense controlled substances in violation
    of 21 U.S.C. § 846. Counts 2 through 4 charged him with distributing and
    dispensing, and aiding and abetting the distribution and dispensing of, controlled
    substances in violation of 21 U.S.C. § 841(a)(1). Count 23 charged him with
    conspiring to commit money laundering in violation of 18 U.S.C. § 1956(h).
    Counts 24 through 26 charged him with committing “financial transaction” money
    laundering in violation of 18 U.S.C. § 1957. And Counts 27 and 28 charged him
    with committing “concealment” money laundering in violation of 18 U.S.C.
    § 1956(a)(1)(B)(i).
    Iriele pleaded not guilty and went to trial. Over the course of three weeks
    the government presented 25 witnesses, including four experts, and the defense
    presented two witnesses, including one expert. Iriele did not testify. The jury
    found him guilty of all ten counts. The district court entered a judgment of
    conviction and sentenced him to 240 months in prison “as to each of Counts 1–4,
    5
    There had been two earlier versions of the indictment, but they had named only
    defendants who worked for AMARC. Iriele was not named until the second superseding
    indictment, which was issued on September 5, 2013. For simplicity’s sake, we will refer to the
    second superseding indictment as “the indictment” throughout this opinion.
    11
    USCA11 Case: 17-13455           Date Filed: 10/09/2020         Page: 12 of 55
    23, 27 and 28,” and 120 months in prison “as to Counts 24–26,” with “all terms to
    be served concurrently.”
    By our tally, Iriele raises 15 different issues on appeal. We have carefully
    considered all of those issues. Some merit discussion. Most don’t. We will limit
    our discussion to the following issues: (1) whether the district court erred by
    allowing a federal agent to testify that a certain document was written in Iriele’s
    handwriting; (2) whether the evidence was sufficient to convict Iriele of the
    charges against him; (3) whether the district court plainly erred when it instructed
    the jury on the standard to convict under § 841(a)(1); and (4) whether the district
    court plainly erred by failing to instruct the jury on several money laundering
    charges. 6
    6
    In addition to those four issues, Iriele also contends that the district court: (1) abused its
    discretion by admitting videos and testimony that contained hearsay statements; (2) abused its
    discretion by admitting evidence of Iriele’s prior convictions and license revocation under Fed.
    R. Evid. 404(b); (3) abused its discretion by excluding evidence of a government witness’s
    supposed misconduct during an earlier investigation; (4) abused its discretion by admitting
    evidence of an AMARC customer’s non-fatal overdoses without any proof that the customer
    overdosed on prescriptions filled at MCP; (5) abused its discretion by admitting state and federal
    law as substantive evidence; (6) abused its discretion by admitting testimony from an expert
    witness that was outside the scope of his expertise; (7) erred by admitting a handwritten
    document into evidence without enough known samples of Iriele’s handwriting for the jury to
    compare with the handwriting in the disputed document; (8) erred by instructing the jury on a
    means of violating 18 U.S.C. § 1956 that was not alleged in the indictment; (9) plainly erred by
    failing to instruct the jury that it was ultimately up to the jury to decide whether Iriele had
    authored a certain handwritten document; (10) erred by instructing the jury that good faith was
    irrelevant to Counts 2 through 4; and (11) plainly erred in instructing the jury on 21 U.S.C.
    § 846.
    We will not discuss why those scattershot contentions lack merit. Cf. Dominguez v. Tom
    James Co., 
    113 F.3d 1188
    , 1190 (11th Cir. 1997) (“None of the [appellant’s] other issues that we
    have listed above merit[s] any further discussion.”). But we remind counsel that raising a
    plethora of issues is not good advocacy. Rogers v. Zant, 
    13 F.3d 384
    , 388 (11th Cir. 1994)
    12
    USCA11 Case: 17-13455          Date Filed: 10/09/2020       Page: 13 of 55
    III. HANDWRITING TESTIMONY
    During a search of Iriele’s home, investigators seized a handwritten ledger
    detailing certain transactions that Iriele used to launder MCP’s money. The ledger
    was relevant to Counts 27 and 28, the concealment money laundering charges. Its
    admissibility and significance depended in part on whether Iriele had authored it.
    Over Iriele’s objection, the district court allowed a law enforcement agent who had
    investigated Iriele’s money laundering schemes to give an opinion to the jury about
    whether the handwriting in the ledger was Iriele’s. His opinion was that it was.
    Iriele contends that under Federal Rule of Evidence 901(b)(2) the district
    court should not have allowed the agent to testify that Iriele had written the ledger.
    That rule provides that a nonexpert can testify “that handwriting is genuine, based
    on a familiarity with it that was not acquired for the current litigation.” Fed. R.
    Evid. 901(b)(2). Iriele argues that the agent’s opinion about the handwriting in the
    ledger was barred by Rule 901(b)(2) because the agent became familiar with
    Iriele’s handwriting only while investigating this case. Our review is only for
    abuse of discretion. United States v. Frank, 
    599 F.3d 1221
    , 1239 (11th Cir. 2010).
    The assumption tucked into Iriele’s argument is that when an investigator
    becomes familiar with a defendant’s handwriting in the course of investigating a
    (“[A]s the Supreme Court has stressed, we know good advocacy requires the winnowing out of
    some arguments in favor of stressing others: multiplicity of arguments or defenses hints at the
    lack of confidence in any one.”).
    13
    USCA11 Case: 17-13455      Date Filed: 10/09/2020    Page: 14 of 55
    crime, Rule 901(b)(2) categorically bars him from identifying that handwriting in
    any resulting prosecution because his familiarity was “acquired for the current
    litigation.” We have never held that. Several of our sister circuits have addressed
    this issue and all of them have held that an investigator can identify a defendant’s
    handwriting after becoming familiar with it during a criminal investigation. See
    United States v. Harris, 
    786 F.3d 443
    , 447–48 (6th Cir. 2015); United States v. Ali,
    
    616 F.3d 745
    , 753–54 (8th Cir. 2010); United States v. Samet, 
    466 F.3d 251
    , 256
    (2d Cir. 2006); United States v. Scott, 
    270 F.3d 30
    , 48–50 (1st Cir. 2001). Each of
    those circuits has drawn a distinction, either explicitly or implicitly, between
    becoming familiar with someone’s handwriting “for the current litigation” and
    doing so for the purpose of determining if the defendant has committed a crime.
    See 
    Harris, 786 F.3d at 448
    (expressly drawing that distinction); 
    Samet, 466 F.3d at 256
    (same); 
    Scott, 270 F.3d at 50
    (same); see also 
    Ali, 616 F.3d at 754
    (“During
    the investigation Agent Tarr gained familiarity with [the defendant’s] bank
    signature card and fingerprint card, which . . . was sufficient to authenticate the
    exhibits [under Rule 901(b)(2)].”). We agree with those four decisions of our
    sister circuits.
    A lay witness becomes familiar with someone’s handwriting “for the current
    litigation” when he does so solely for the purpose of identifying it at trial. Rule
    901(b)(2) bars such a witness from identifying the handwriting because if he did,
    14
    USCA11 Case: 17-13455          Date Filed: 10/09/2020       Page: 15 of 55
    he would be intruding in an area that is “reserved to the expert [witness].” Fed. R.
    Evid. 901(b)(2) advisory committee’s note to 1972 proposed rules. As the Second
    Circuit has observed: “While a lay witness may not enter court, see for the first
    time two samples of handwriting, and identify the contested sample as written by
    the same person as the previously authenticated sample, that is precisely what an
    expert is charged with doing.” 
    Samet, 466 F.3d at 255
    –56 (cleaned up). The same
    thing is true “if the witness compared the two samples [for that purpose] before
    entering the courtroom.” 
    Scott, 270 F.3d at 50
    ; see, e.g., United States v. Pitts, 
    569 F.2d 343
    , 348 (5th Cir. 1978) (affirming the district court’s exclusion of opinion
    testimony by a lay witness who made a “one-shot comparison” between
    handwriting samples in preparation for an upcoming trial).7 But a lay witness who
    became familiar with the defendant’s handwriting for some purpose other than
    identifying it at trial does not usurp the role of the expert witness, even if he later
    offers an opinion about the handwriting at trial. See 
    Samet, 466 F.3d at 255
    –56.
    7
    The Pitts decision, which is binding precedent, see Bonner v. City of Prichard, 
    661 F.2d 1206
    , 1209 (11th Cir. 1981) (en banc), noted that the lay witness in question “acquired any
    [handwriting] expertise he arguably had for purposes of a pending criminal 
    investigation.” 569 F.2d at 348
    . That was one of the reasons why the Court held that the witness’s handwriting
    opinion testimony was properly excluded under Rule 901(b)(2). See
    id. At first glance,
    Pitts
    might seem to stand for the proposition that a witness who learns someone’s handwriting “for
    purposes of a pending criminal investigation” can’t offer an opinion about that handwriting
    under Rule 901(b)(2). But the lay witness in Pitts was not an investigator trying to solve a crime;
    he was a lawyer who was preparing to defend his client at an upcoming criminal trial. See
    id. at 348
    & n.9. That means the lay witness in Pitts — unlike the lay witness here — became familiar
    with the handwriting at issue for the purpose of using that knowledge at trial.
    15
    USCA11 Case: 17-13455           Date Filed: 10/09/2020       Page: 16 of 55
    An investigator who becomes familiar with the defendant’s handwriting for
    the purpose of solving a crime is different from a lay witness who makes a
    handwriting comparison so he can testify about it at trial. That investigator is in
    the same position as any other lay witness who, as part of his job or in his day-to-
    day affairs, has seen examples of the defendant’s handwriting, such as the
    defendant’s “accountant, employee[,] or family member.”
    Id. at 256.
    His opinion
    about the defendant’s handwriting is not categorically barred by Rule 901(b)(2).8
    This interpretation of Rule 901(b)(2) is supported by its context. We have
    read Rule 901(b)(2) in tandem with Federal Rule of Evidence 701, which governs
    opinion testimony by lay witnesses, because “testimony purporting to satisfy the
    specific requirements of Rule 901(b)(2) must also satisfy the general requirements
    in Rule 701.” Hall v. United Ins. Co. of Am., 
    367 F.3d 1255
    , 1259 (11th Cir.
    2004). Rule 701(b) provides that lay opinion testimony is not admissible unless it
    would be helpful to the jury. Our holding about the meaning of Rule 901(b)(2)
    8
    We say “categorically” because Rule 901(b)(2) imposes more than one restriction on
    lay opinion testimony about handwriting. We have held that Rule 901(b)(2), when read together
    with Federal Rule of Evidence 701, requires a witness to establish “with particularity” how he
    became familiar with the handwriting in question and what relationship he has with the
    handwriting’s author before he can give an opinion about it. See Hall v. United Ins. Co. of Am.,
    
    367 F.3d 1255
    , 1259–61 (11th Cir. 2004). An investigator’s lay opinion about handwriting will
    be barred by Rule 901(b)(2) and Rule 701 if he fails to lay the necessary foundation. See
    id. Iriele does not
    argue that the agent who testified about his handwriting at trial failed to lay the
    necessary foundation. Instead his argument is that the agent’s testimony should have been
    excluded categorically under Rule 901(b)(2) because the agent became familiar with his
    handwriting during a criminal investigation. We disagree.
    16
    USCA11 Case: 17-13455       Date Filed: 10/09/2020       Page: 17 of 55
    excludes lay opinion testimony that would be unhelpful to the jury. A nonexpert
    witness who becomes familiar with the defendant’s handwriting for the purpose of
    identifying it at trial does not assist the jury because “such a comparison could be
    made as easily by the jury as by the witness.” 
    Scott, 270 F.3d at 50
    ; see also
    
    Samet, 466 F.3d at 255
    (“A lay witness who lacks prior familiarity with a person’s
    handwriting and forms an opinion on it for the first time in preparation for
    testimony as a witness does not offer helpful testimony.”). But a lay witness who
    is exposed to the defendant’s handwriting many times during a months- or years-
    long investigation does help the jury because he possesses “the extent of
    familiarity contemplated by [Rule] 901(b)(2),” 
    Pitts, 569 F.2d at 348
    , which the
    jury is unlikely to have gained during the course of the trial.
    For those reasons, the district court did not err by allowing the agent who
    had become familiar with Iriele’s handwriting during his investigation to offer his
    opinion that the handwriting in the ledger was Iriele’s.
    IV. SUFFICIENCY OF THE EVIDENCE
    “When a defendant preserves a challenge to the sufficiency of the
    government’s evidence by moving for a judgment of acquittal, we review the
    sufficiency of the evidence de novo.” United States v. Watts, 
    896 F.3d 1245
    , 1250
    (11th Cir. 2018). In doing so, we “view[] the evidence in the light most favorable
    to the verdict and draw[] all reasonable inferences and credibility choices in the
    17
    USCA11 Case: 17-13455           Date Filed: 10/09/2020         Page: 18 of 55
    verdict’s favor.” United States v. Godwin, 
    765 F.3d 1306
    , 1319 (11th Cir. 2014)
    (quotation marks omitted). A guilty verdict “cannot be overturned if any
    reasonable construction of the evidence would have allowed the jury to find the
    defendant guilty beyond a reasonable doubt.” United States v. Rodriguez, 
    732 F.3d 1299
    , 1303 (11th Cir. 2013). “Because a jury is free to choose among the
    reasonable constructions of the evidence, it is not necessary that the evidence
    exclude every reasonable hypothesis of innocence or be wholly inconsistent with
    every conclusion except that of guilt.” 
    Godwin, 765 F.3d at 1320
    (quotation marks
    omitted). 9
    Iriele challenges the sufficiency of the evidence for his drug offense
    convictions and his money laundering convictions. We will address his challenges
    in that order.
    A. Drug Conspiracy Conviction
    Count 1 of the indictment charged Iriele with violating 21 U.S.C. § 846 by
    conspiring with the owners of AMARC, two of AMARC’s doctors who were
    9
    The government argues that Iriele did not renew his motion for judgment of acquittal
    after the close of all evidence and that as a result, we should review only for a “manifest
    miscarriage of justice.” It is true that Iriele initially forgot to renew his motion. But as soon as
    trial began the next day, his lawyer stated: “One thing, Judge. I forgot at the close of the
    evidence to renew our Rule 29. I’ll just do that. I don’t have any additional argument.” The
    court said: “All right. I note your motion[], and I will maintain the previous ruling[].” Because
    the district court accepted Iriele’s late renewal and the government did not object to the court
    doing so, we will also consider the motion as though it had been timely renewed and apply the
    usual de novo standard of review.
    18
    USCA11 Case: 17-13455       Date Filed: 10/09/2020    Page: 19 of 55
    named, and Ofume to distribute and dispense controlled substances (oxycodone,
    oxycodone with acetaminophen, methadone, hydromorphone, hydrocodone with
    acetaminophen, alprazolam, and carisoprodol) in violation of 21 U.S.C.
    § 841(a)(1). To convict a defendant of that crime, the government must prove
    three things: (1) there was an agreement between two or more people to unlawfully
    distribute and dispense controlled substances in violation of § 841(a)(1); (2) the
    defendant knew about the agreement; and (3) the defendant “voluntarily joined”
    the agreement. United States v. Azmat, 
    805 F.3d 1018
    , 1035 (11th Cir. 2015).
    We begin with an explanation of how § 841(a)(1) applies to physicians and
    pharmacists. Or rather, how it does not apply to them if they are legitimately
    dispensing controlled substances. An exception allows physicians to issue
    prescriptions for controlled substances and allows pharmacists to fill them. See
    21 U.S.C. § 829. Regulations specify when the exception applies and when it
    doesn’t. Those regulations provide that the prescription must be “issued for a
    legitimate medical purpose by an individual practitioner acting in the usual course
    of his professional practice.” 21 C.F.R. § 1306.04(a). They also provide that
    “[t]he responsibility for the proper prescribing and dispensing of controlled
    substances is upon the prescribing practitioner, but a corresponding responsibility
    rests with the pharmacist who fills the prescription.”
    Id. If a prescription
    isn’t
    issued for a legitimate medical purpose in the usual course of a practitioner’s
    19
    USCA11 Case: 17-13455       Date Filed: 10/09/2020   Page: 20 of 55
    practice, “the person knowingly filling such a purported prescription, as well as the
    person issuing it,” violates § 841(a)(1).
    Id. Reading all of
    the relevant provisions
    together, we have explained the basic framework this way:
    To convict a licensed physician under section 841(a)(1), it is incumbent
    upon the government to prove that he dispensed controlled substances
    for other than legitimate medical purposes in the usual course of
    professional practice, and that he did so knowingly and intentionally.
    And to convict a licensed pharmacist under section 841(a)(1), the
    government must prove that the pharmacist filled a prescription
    knowing that a physician issued the prescription without a legitimate
    medical purpose or outside the usual course of professional practice.
    United States v. Joseph, 
    709 F.3d 1082
    , 1094 (11th Cir. 2013) (cleaned up).
    With that framework in mind, we turn back to the elements of § 846. Iriele
    concedes that the first element (whether an agreement existed) is met in this case
    because the AMARC defendants did agree to issue prescriptions without a
    legitimate medical purpose and outside the usual course of professional practice.
    But he contests the other two elements, contending that the evidence was
    insufficient to show that he personally knew about the agreement among the
    AMARC defendants themselves or that he voluntarily joined that agreement.
    1. The Knowledge Element
    Iriele contends that there was insufficient evidence to prove he knew that
    AMARC doctors and employees had agreed to run the clinic in a way that
    unlawfully distributed or dispensed drugs. He argues that no direct evidence was
    presented that he knew of their agreement. He’s right. The government presented
    20
    USCA11 Case: 17-13455       Date Filed: 10/09/2020   Page: 21 of 55
    no evidence that Iriele ever had any discussions with the AMARC defendants, or
    ever overheard any discussions among them, about their agreement to operate a pill
    mill. But the lack of direct evidence does not end the inquiry.
    The government can prove a § 846 conspiracy with circumstantial evidence,
    and when it comes to knowledge of a conspiracy we have said that the government
    does enough when it shows that “the circumstances surrounding a person’s
    presence at the scene of conspiratorial activity are so obvious that knowledge of its
    character can fairly be attributed to him.” 
    Azmat, 805 F.3d at 1035
    (quotation
    marks omitted); see also United States v. Tamargo, 
    672 F.2d 887
    , 889 (11th Cir.
    1982) (“Proof is not required that the defendant had knowledge of all the details of
    the conspiracy; the defendant need only have knowledge of the essential objective
    of the conspiracy.”). If the evidence shows that it would have been obvious to
    Iriele that the AMARC defendants had agreed among themselves to issue
    prescriptions without a legitimate medical purpose or outside the usual course of
    professional practice, Iriele loses this argument.
    Because Iriele did not work at AMARC and nothing at trial indicated that he
    was ever present inside the AMARC office, we look to whether the things he saw
    and heard at MCP and by virtue of his position there would have made it obvious
    to Iriele that AMARC was an illegal pill mill being operated by the other
    defendants. They would have.
    21
    USCA11 Case: 17-13455       Date Filed: 10/09/2020   Page: 22 of 55
    To start with, Iriele was well aware of the kinds of prescriptions that
    AMARC was issuing. He was because he was the co-operator of MCP, he was at
    the pharmacy much of the time, he handled the pharmacy’s paperwork, he helped
    to ring up the prescriptions, and he had full access to the computer that the
    pharmacists used to process prescriptions. He had to know, and the jury could
    have found that he did know, the vast majority of the prescriptions that MCP filled
    came from AMARC. As a result, Iriele had to know that AMARC’s doctors were
    issuing an enormous number of prescriptions for large quantities of opioids,
    Xanax, and Soma, often in combination for a patient.
    It would have been obvious to a trained pharmacist like Iriele that those
    prescriptions were illegitimate. One red flag was the sheer volume of opioids that
    AMARC prescribed. MCP had to order hundreds of thousands of doses of opioids
    each year to keep up with demand from AMARC patients — far more than any
    other pharmacy in the area –– and for one year more than any other pharmacy in
    the state. See United States v. Hammond, 
    781 F.2d 1536
    , 1538 (11th Cir. 1986)
    (affirming pharmacist’s conviction where the evidence showed that the
    “outrageous volume” of controlled substances prescribed by a pill mill “would
    have alerted any pharmacist that prescriptions were being improperly issued,” but
    the pharmacist filled those prescriptions anyway).
    22
    USCA11 Case: 17-13455     Date Filed: 10/09/2020   Page: 23 of 55
    Another red flag was the drug combinations that AMARC prescribed. Two
    of the government’s experts testified that oxycodone, Xanax, and Soma are
    commonly abused together, and one of those experts added that those three drugs
    have been “described in the pharmacy and medical literature as the unholy holy
    trinity for substance abuse.” The same expert explained that there is no legitimate
    reason for a single patient to be using those three drugs together for more than a
    short period of time.
    In addition to that, Iriele saw the customers who were coming into MCP to
    fill all those AMARC prescriptions. It would have been obvious to anyone that
    many of those customers were seeking and obtaining drugs for something other
    than a legitimate medical purpose. For one thing, the customers unmistakably
    exhibited signs of being drug addicts. Witnesses at trial testified that AMARC’s
    patients were underweight, had track marks on their arms, were missing teeth or
    losing hair, and were “disheveled,” “unkempt,” and “living and talking and
    wanting and breathing” for pills. MCP’s pharmacy technician testified that
    customers would sometimes come in “not looking right, passing out, [or] falling
    asleep.”
    Another fact that had to have been apparent to Iriele is that most of
    AMARC’s patients were between 20 and 50 years old. The government’s medical
    expert testified that was “pretty unusual” because patients who experience the type
    23
    USCA11 Case: 17-13455         Date Filed: 10/09/2020       Page: 24 of 55
    of chronic pain that warrants the use of controlled substances are typically between
    40 and 80 years old.
    Iriele also would have noticed as he was ringing up customers that many of
    them were from out of state. The record indicates that MCP, like other pharmacies
    in the area, required customers to provide their driver’s licenses before they could
    have their prescriptions filled. That means Iriele would have known where
    AMARC’s patients were coming from.10 According to the government’s medical
    expert, the fact that a patient comes a long way for what should be a
    straightforward medical appointment is a red flag that the patient may be a habitual
    drug abuser looking for controlled substances.
    Based on all the red flags involving the quantity and nature of AMARC’s
    prescriptions as well as the characteristics of AMARC’s patients, other pharmacists
    in the area had concluded that AMARC was operating a pill mill and started
    turning the clinic’s patients away.
    10
    MCP’s pharmacy technician testified that MCP “didn’t take out-of-state doctors or
    people who lived out of state.” But MCP’s own records show that between 2009 and 2012 it
    dispensed thousands of prescriptions to customers who reported out-of-state addresses. A
    reasonable jury could have credited MCP’s internal records over the testimony of MCP’s
    pharmacy technician. See United States v. Godwin, 
    765 F.3d 1306
    , 1319 (11th Cir. 2014)
    (stating that when we review the sufficiency of the evidence, we “draw[] all reasonable
    inferences and credibility choices in the verdict’s favor”) (quotation marks omitted). And even if
    Iriele didn’t personally ring up all of those thousands of prescriptions, a reasonable jury could
    have found that he likely would have seen the customers’ out-of-state addresses when he did the
    pharmacy’s paperwork.
    24
    USCA11 Case: 17-13455       Date Filed: 10/09/2020    Page: 25 of 55
    For example, Jignesh Patel testified that he had refused to fill AMARC’s
    prescriptions for four or five customers at his pharmacy. He did so because he had
    noticed that the customers were poorly dressed, looked “shaggy,” and smelled bad.
    The customers did not seem to have any serious medical conditions that would
    justify their prescriptions for large quantities of oxycodone, Soma, and Xanax.
    One of the customers showed him an out of state driver’s license, which was
    another warning sign for him. And he thought the prescriptions themselves were
    suspect: he believed that a legitimate doctor would not write a prescription for a
    large quantity of Xanax combined with pain medication.
    Another pharmacist, Clementine Nanje, testified that she had a list of clinics
    and doctors whose prescriptions her pharmacy would refuse to fill and that
    AMARC and its doctors were on that list.
    And pharmacist Jennifer Brandee Hinson testified that her standard practice
    was to refuse to fill AMARC’s prescriptions because the clinic’s patients were
    from out of state (as reflected on their driver’s licenses) and had prescriptions for
    large quantities of controlled substances. At one point she even emailed the
    Georgia Drugs and Narcotics Agency to let officials know about AMARC’s
    suspicious prescriptions.
    Those were not the only pharmacists who refused to fill AMARC’s
    prescriptions for controlled substances. At trial, AMARC’s patients and
    25
    USCA11 Case: 17-13455      Date Filed: 10/09/2020   Page: 26 of 55
    employees testified that other pharmacies throughout the state were turning away
    AMARC’s controlled substance prescriptions.
    Given that mountain of evidence, a jury could reasonably have concluded
    that Iriele, like all those other pharmacists, knew that AMARC’s owners and
    doctors were running a pill mill, working together to prescribe controlled
    substances without a legitimate medical purpose and outside the usual course of
    professional practice. See 
    Azmat, 805 F.3d at 1035
    –37 (holding that the evidence
    was sufficient to show that a physician knowingly and voluntarily joined an
    agreement to unlawfully dispense controlled substances in part because “there was
    an abundance of red flags that should have tipped off any doctor that his patients
    were seeking pills”); 
    Joseph, 709 F.3d at 1104
    (“Conduct that suggests that a
    defendant distributed a prescription without a legitimate medical purpose and
    outside the usual course of professional practice includes conduct where an
    inordinately large quantity of controlled substances was prescribed [and] large
    numbers of prescriptions were issued.”) (cleaned up). As a result, Iriele’s
    argument that the evidence was insufficient to show that he knew that the AMARC
    defendants were knowingly working in concert with each other fails.
    2. The Participation Element
    Iriele also contends that there was insufficient evidence to prove the
    participation element of his § 846 conviction. He argues that the evidence was
    26
    USCA11 Case: 17-13455       Date Filed: 10/09/2020    Page: 27 of 55
    insufficient to prove that he voluntarily participated in the AMARC defendants’
    agreement. Like knowledge, participation can be proved with circumstantial
    evidence. See United States v. Russo, 
    717 F.2d 545
    , 549 (11th Cir. 1983). And
    one way to prove through circumstantial evidence that a defendant joined a
    conspiracy is by showing that he committed acts that furthered the purpose of the
    conspiracy. United States v. Frink, 
    912 F.2d 1413
    , 1416 (11th Cir. 1990). The
    government presented more than enough evidence to show that Iriele did that.
    It does no good for a pill mill to grind out truckloads of prescriptions if no
    pharmacy will fill them. In order for the AMARC conspiracy to operate
    successfully, it needed a pharmacy to fill the prescriptions it issued. That’s what
    MCP did, and that’s how Iriele participated in the effort, in the conspiracy.
    One of AMARC’s employees testified that MCP was “where most of the
    patients went and had their prescriptions filled.” A government data analyst
    prepared a summary showing that MCP filled more of AMARC’s prescriptions
    than any other pharmacy. MCP filled so many of AMARC’s prescriptions that
    AMARC’s patients became its primary source of business. Between 2009 and
    2012 AMARC’s prescriptions accounted for more than 83% of MCP’s dispensing
    and over 90% of the pharmacy’s gross sales. That is participating big time in what
    AMARC was doing.
    27
    USCA11 Case: 17-13455      Date Filed: 10/09/2020    Page: 28 of 55
    As time went on, MCP’s continued willingness to fill AMARC’s
    prescriptions became more critical to the AMARC defendants’ ability to illegally
    distribute controlled substances. As we have already discussed, other pharmacists
    realized that AMARC was running a pill mill and started turning its patients away.
    See Part 
    IV.A.1, supra
    . But MCP and Iriele did not turn AMARC’s patients away.
    In fact, the owners of AMARC were so sure that MCP would keep participating in
    making the pill mill operation work that they told the clinic’s doctors and
    employees to send any patients who were turned away by other pharmacies to
    MCP. And that’s exactly what AMARC’s doctors and employees did until the
    Drug Enforcement Agency shut down the clinic.
    The arrangement between AMARC and MCP worked so well that patients
    saw the two businesses as “related,” “connected,” or a “monopoly.” And one
    owner of AMARC even approached Ofume about the possibility of him opening
    up a new clinic in Alabama and MCP opening up a pharmacy nearby.
    Just as MCP was a crucial part of AMARC’s operation, Iriele was a crucial
    part of MCP’s operation. Either he or Ofume was at the pharmacy at all times.
    Iriele would often ring up customers, and he told them about MCP’s prices (which
    were unusually high) and the fact that MCP would accept only cash for controlled
    substance prescriptions. He was responsible for the pharmacy’s paperwork. He
    and Ofume counted the pharmacy’s cash at the end of the day, and he was an
    28
    USCA11 Case: 17-13455      Date Filed: 10/09/2020   Page: 29 of 55
    authorized signer on MCP’s bank accounts. Two of AMARC’s patients testified
    that Iriele himself filled their prescriptions, even though his pharmacy license had
    been revoked.
    On those facts, a reasonable jury could have concluded that Iriele voluntarily
    joined the conspiracy with AMARC’s doctors and owners to illegally dispense
    controlled substances. See 
    Hammond, 781 F.2d at 1538
    (concluding that the
    evidence was sufficient to show that a pharmacist participated in and furthered a
    physician’s scheme in part because (1) “the great bulk of prescriptions issued” by
    that physician were filled by the pharmacist, and (2) the pharmacist “began
    functioning as a virtual wholesaler of the controlled drug” that the physician was
    issuing, with the pharmacy purchasing over 80% of the manufacturer’s stock for
    that sales territory).
    B. Dispensing and Distribution Conviction
    Iriele also contends there was insufficient evidence to convict him of Counts
    2 through 4 of the indictment, which charged him with violating § 841(a)(1) by
    distributing and dispensing, and aiding and abetting the distribution and dispensing
    of, controlled substances. Those charges were based on three occasions when
    MCP filled undercover agent Chris Crutchfield’s AMARC prescriptions for
    Roxicodone. Iriele contends that the government failed to prove that he: (1) knew
    that the prescriptions were issued without a legitimate medical purpose or outside
    29
    USCA11 Case: 17-13455        Date Filed: 10/09/2020    Page: 30 of 55
    the course of professional practice, and (2) filled the prescriptions or willfully
    aided and abetted MCP pharmacists in filling the prescriptions.
    But, as we have already discussed, the evidence was sufficient to show that
    Iriele knew AMARC was prescribing controlled substances without a legitimate
    medical purpose and outside the usual course of professional practice. See Part
    
    IV.A.1, supra
    . And under our precedent the government was not required to show
    that Iriele was the one who actually filled the prescriptions or that he personally
    helped another pharmacist fill them. The fact Iriele knew AMARC was issuing
    illegitimate prescriptions and allowed the pharmacists that he employed to fill
    thousands of those prescriptions, including the three involved here, was evidence
    enough. See 
    Hammond, 781 F.2d at 1538
    –39 (rejecting pharmacist’s nearly
    identical argument).
    C. Money Laundering Conspiracy Conviction
    Count 23 charged Iriele with violating § 1956(h) by conspiring with Ofume
    to commit promotional, financial transaction, concealment, and structuring money
    laundering. Promotional money laundering is the use of illegally-obtained money
    to fund more illegal activity. See 18 U.S.C. § 1956(a)(1)(A)(i). Financial
    transaction money laundering is the use of a financial institution to conduct a
    monetary transaction involving more than $10,000 of illegally obtained funds. See
    id. § 1957. Concealment
    money laundering is any transaction designed to conceal
    30
    USCA11 Case: 17-13455       Date Filed: 10/09/2020    Page: 31 of 55
    or disguise the true nature or location of illegally obtained funds. See
    id. § 1956(a)(1)(B)(i). And
    structuring money laundering is the use of illegally
    obtained funds to carry out a financial transaction that is designed to avoid a state
    or federal reporting requirement. See
    id. § 1956(a)(1)(B)(ii). To
    convict a defendant of conspiracy to commit money laundering, the
    government must prove “(1) an agreement between two or more persons to commit
    a money-laundering offense; and (2) knowing and voluntary participation in that
    agreement by the defendant.” United States v. Feldman, 
    936 F.3d 1288
    , 1307
    (11th Cir. 2019) (quotation marks omitted). The government can do that by using
    “circumstantial evidence, including inferences from the conduct of the alleged
    participants or from circumstantial evidence of a scheme.” 
    Azmat, 805 F.3d at 1037
    (quotation marks omitted).
    And when the indictment lists more than one object of the conspiracy, as it
    did here, the evidence “need only be sufficient for any one of the charged objects
    to sustain a conviction.” United States v. Moran, 
    778 F.3d 942
    , 963 (11th Cir.
    2015). That means so long as the jury could reasonably have concluded that Iriele
    and Ofume made an agreement to commit promotional money laundering,
    concealment money laundering, financial transaction money laundering, or
    structuring money laundering, the evidence was sufficient to convict. See
    
    Feldman, 936 F.3d at 1307
    –08.
    31
    USCA11 Case: 17-13455       Date Filed: 10/09/2020      Page: 32 of 55
    The jury could reasonably have concluded that Iriele and Ofume made an
    agreement to commit promotional money laundering and that Iriele knowingly and
    voluntarily participated in that agreement. Again, that type of money laundering
    occurs when a person uses funds from an unlawful activity to promote carrying out
    more unlawful activity. 
    Azmat, 805 F.3d at 1037
    .
    The evidence proved that both Iriele and Ofume knew the money MCP
    earned from filling AMARC’s prescriptions was criminally derived. We have
    already explained, while discussing the drug conspiracy conviction, how the
    evidence showed that Iriele knew MCP was unlawfully filling prescriptions. See
    Part 
    IV.A.1, supra
    . The same evidence shows that Iriele knew the money MCP
    earned was criminally derived. See 
    Feldman, 936 F.3d at 1307
    (“[B]ased on our
    conclusion that sufficient evidence supported the drug conspiracy conviction, it
    necessarily follows that the [defendants] knew that the transactions involved the
    proceeds of unlawful activity.”). The evidence proves Ofume’s knowledge too.
    And we can add to that evidence the fact that Ofume had visited AMARC on
    multiple occasions and had a relationship with AMARC’s owners and doctors. 11
    11
    In addition to the challenge that relates only to his money laundering conspiracy
    conviction, Iriele challenges all of his money laundering convictions — Counts 23 through 28 —
    on the ground that the government failed to prove that he knew MCP’s money was criminally
    derived. That challenge fails for the reasons we have just discussed.
    32
    USCA11 Case: 17-13455        Date Filed: 10/09/2020    Page: 33 of 55
    The evidence shows that MCP made most of its money by filling AMARC’s
    prescriptions. As we have already discussed, MCP’s pharmacy technician testified
    that 80% to 85% of MCP’s customers obtained their prescriptions from AMARC,
    and a government data analyst testified that AMARC’s prescriptions accounted for
    90% of the pharmacy’s gross sales. See Part 
    IV.A.2, supra
    . Iriele and Ofume
    managed that money together. Both counted MCP’s cash at the end of the day,
    both made deposits into the MCP bank account, and both were authorized signers
    on the MCP bank account.
    Finally, much of that money was used to purchase more controlled
    substances to dispense. Ofume issued checks from the jointly controlled MCP
    bank account to purchase controlled substances for the pharmacy from drug
    distributors. Between 2009 and 2012, MCP paid over $3 million from its bank
    account to 32 different drug distributors to purchase drugs to distribute.
    For those reasons, the evidence was sufficient for a jury to conclude that
    Iriele conspired with Ofume to commit promotional money laundering.
    V. JURY INSTRUCTIONS
    Iriele contends that the district court made various errors in its jury
    instructions. Not all of his jury instruction challenges merit discussion, but two of
    them do: his contentions that the district court erred in its instructions to the jury on
    33
    USCA11 Case: 17-13455       Date Filed: 10/09/2020   Page: 34 of 55
    the standard to convict a pharmacist under § 841(a)(1), and that it erred by failing
    to separately instruct the jury on § 1956(h) and § 1957.
    A. The Instructions and Iriele’s Arguments
    Before we can assess Iriele’s arguments, we need to describe his challenges
    to the jury instructions and the arguments behind those challenges.
    Counts 2, 3, and 4 of the indictment charged Iriele with three separate
    violations of 21 U.S.C. § 841(a)(1). The court instructed the jury, in relevant part:
    Counts 2, 3, [and] 4 charge that Defendants knowingly and
    intentionally distributed controlled substances outside the course of
    professional medical practice and for other than a legitimate medical
    purpose.
    ....
    Title 21 United States Code Section 841(a)(1) makes it a crime
    for anyone to knowingly or intentionally . . . distribute or dispense a
    controlled substance, except as authorized by federal law. Because
    many controlled substances have an accepted medical use, federal law
    authorizes registered practitioners [including pharmacists] to distribute
    and dispense controlled substances for legitimate medical purposes
    within the usual course of professional practice.
    ....
    . . . [A] pharmacist has violated Section 841(a)(1) when the
    Government has proved beyond a reasonable doubt that the
    pharmacist[’s] actions were not for legitimate medical purposes or were
    outside the usual course of professional practice.
    ....
    The Defendant can be found guilty of this crime only if all the
    following facts are proved beyond a reasonable doubt:
    34
    USCA11 Case: 17-13455        Date Filed: 10/09/2020    Page: 35 of 55
    ....
    (2) the Defendant intended to distribute and dispense these
    substances outside the course of professional practice or without
    a legitimate medical purpose.
    ....
    A pharmacist may be convicted of a violation of Title 21, United
    States Code, Section 841(a)(1) when s/he dispenses a controlled
    substance either outside the usual course of professional practice or
    without a legitimate medical purpose.
    As that excerpt shows, the district court consistently instructed the jury that a
    pharmacist violates § 841(a)(1) when he dispenses a controlled substance outside
    the usual course of professional practice or without a legitimate medical purpose.
    Iriele argues that those instructions were plainly erroneous because, under
    our binding precedent, “[t]he jury should have been, but never was, instructed that
    to convict Mr. Iriele under § 841(a)(1), it had to find that he filled a prescription
    knowing that a physician issued the prescription without a legitimate medical
    purpose or outside the usual course of professional practice.” Appellant’s Br. at
    44–45. He argues that the error affected his substantial rights and seriously
    affected the fairness, integrity, or public reputation of judicial proceedings because
    it allowed the jury to convict him “without finding that he had any criminal intent.”
    Appellant’s Br. at 46–47.
    Count 23 of the indictment charged Iriele with conspiracy to commit money
    laundering in violation of 18 U.S.C. § 1956(h). The court instructed the jury:
    35
    USCA11 Case: 17-13455      Date Filed: 10/09/2020   Page: 36 of 55
    Count 23 charges that Defendants knowingly conspired to
    conduct financial transactions affecting interstate commerce which
    involved the proceeds of the illegal distributing and dispensing of
    controlled substances outside the course of professional practice and
    for other than a legitimate medical purpose, to conceal and disguise the
    nature and source, ownership, and control of the proceeds of this
    unlawful activity, and to avoid a transaction reporting requirement
    under Federal law. Count 23 also charges that Defendants knowingly
    conspired to engage in monetary transactions, by, through, or to a
    financial institution, affecting interstate and foreign commerce in
    criminally derived property of a value greater than $10,000.00.
    ....
    But first note that the Defendants are not charged in Counts 1 and
    23 with committing a substantive offense – they are charged with
    conspiring to commit that offense.
    The court also instructed the jury on the elements of promotional, concealment,
    and structuring money laundering. And within its instructions on those offenses
    the court defined a number of terms, including “financial institution” and
    “proceeds.” The court did not, however, specifically instruct the jury on the
    elements of conspiracy to commit money laundering.
    Counts 24, 25, and 26 of the indictment charged Iriele with financial
    transaction money laundering in violation of 18 U.S.C. § 1957. The court
    instructed the jury:
    Counts 24, 25, [and] 26 charge that Defendant Donatus Iriele
    knowingly engaged in a monetary transaction affecting interstate
    commerce and foreign commerce in criminally derived property that
    was of a value greater than $10,000.00.
    36
    USCA11 Case: 17-13455        Date Filed: 10/09/2020     Page: 37 of 55
    But the court did not specifically instruct the jury on the elements of financial
    transaction money laundering.
    Iriele’s argument about Counts 23 through 26 is simple. He says that “the
    district court erred by entirely failing to instruct the jury on Counts 23–26.”
    Appellant’s Br. at 40. That error “is plainly harmful,” he argues, because “the jury
    had no guidance in convicting Mr. Iriele of these counts.”
    Id. He adds that
    “[i]f
    this Court determines that the issue will be reviewed only for plain error, . . . it was
    plainly erroneous for the district court to fail to instruct the jury on these counts at
    all.”
    Id. at 40
    n.14.
    B. The Standard of Review
    1. The Failure to Object
    If Iriele did not object and preserve those grounds at trial, we review only for
    plain error. He concedes that he did not preserve the § 841(a)(1) error involving
    Counts 2, 3, and 4. But he argues that he did preserve the § 1956(h) and § 1957
    errors and is entitled to de novo review of those issues. In the proposed jury
    instructions he submitted before trial, Iriele requested (among other things)
    separate instructions on § 1956(h) and § 1957. As he sees it, that request is enough
    to preserve the issues even though he did not object when separate instructions
    were not given. He is mistaken about that.
    37
    USCA11 Case: 17-13455          Date Filed: 10/09/2020   Page: 38 of 55
    Federal Rule of Criminal Procedure 30(d) provides that “[a] party who
    objects to any portion of the instructions or to a failure to give a requested
    instruction must inform the court of the specific objection and the grounds for the
    objection before the jury retires to deliberate.” Fed. R. Crim. P. 30(d). The
    objection must be specific enough “to give the district court the chance to correct
    errors before the case goes to the jury.” United States v. Sirang, 
    70 F.3d 588
    , 594
    (11th Cir. 1995). “Without such an objection, we review only for plain error.” Id.;
    accord Fed. R. Crim. P. 30(d) (“Failure to object in accordance with this rule
    precludes appellate review, except as permitted under [Fed. R. Crim. P.] 52(b)
    [governing plain error review].”); see, e.g., United States v. Pepe, 
    747 F.2d 632
    ,
    675 (11th Cir. 1984) (“The issue appellants raise was never preserved, however, by
    proper objection pursuant to Fed. R. Crim. P. 30 . . . [so] our review of this issue is
    limited to correcting plain error.”).
    Before deliberations began, Iriele had an opportunity to object to the district
    court’s jury instructions in the periods before and after they were given. He could
    have objected then as he did to some of the other instructions. He did not,
    however, object then, or at any time, to the court’s failure to give the jury separate
    instructions on § 1956(h) and § 1957. As a result, Iriele did not give the district
    court a chance to correct the error he belatedly complains about. See 
    Sirang, 70 F.3d at 594
    . For that reason, we are limited to plain error review of it.
    38
    USCA11 Case: 17-13455        Date Filed: 10/09/2020    Page: 39 of 55
    2. The Plain Error Standard
    To prevail under plain error review, Iriele must show that the district court
    made an error, that the error was plain, and that it affected his substantial rights.
    United States v. Rodriguez, 
    398 F.3d 1291
    , 1298 (11th Cir. 2005). If he carries
    that burden, we have discretion to reverse — but only if the error seriously affects
    the fairness, integrity, or public reputation of judicial proceedings.
    Id. Satisfying the substantial
    rights prong of plain error review “is anything but
    easy.”
    Id. at 1299.
    To do it, the defendant generally must show a “reasonable
    probability” that the error affected the outcome of the district court proceedings,
    “which means a probability sufficient to undermine confidence in the outcome.”
    Id. (quotation marks omitted).
    The Supreme Court has instructed us that to show
    an error has affected a defendant’s substantial rights for plain error purposes, “in
    most cases . . . the error must have been prejudicial: It must have affected the
    outcome of the district court proceedings.” United States v. Olano, 
    507 U.S. 725
    ,
    734 (1993).
    The substantial rights analysis is like harmless error review but with a twist:
    the defendant, not the government, “bears the burden of persuasion with respect to
    prejudice.” See United States v. Monroe, 
    353 F.3d 1346
    , 1352 (11th Cir. 2003). A
    tie goes to the government. “[I]f it is equally plausible that the error worked in
    favor of the defense, the defendant loses; if the effect of the error is uncertain so
    39
    USCA11 Case: 17-13455        Date Filed: 10/09/2020    Page: 40 of 55
    that we do not know which, if either, side it helped the defendant loses.”
    
    Rodriguez, 398 F.3d at 1300
    . Uncertainty works against reversal. See
    id. (explaining that in
    plain error review, “the burden truly is on the defendant to
    show that the error actually did make a difference.”).
    To merit reversal, a plain error must not only affect the defendant’s
    substantial rights, but must also seriously affect the fairness, integrity, or public
    reputation of judicial proceedings. 
    Olano, 507 U.S. at 736
    . An error does not meet
    that prong merely because it affected the outcome of the trial. Something more is
    required, because “otherwise the discretion afforded by [plain error review] would
    be illusory.”
    Id. at 737.
    A defendant does not have to prove his innocence to use
    the plain error rule
    , id. at 736–37,
    but the Supreme Court has reminded lower
    courts that: “Appellate review under the plain-error doctrine, of course, is
    circumscribed and we exercise our power under Rule 52(b) sparingly.” Jones v.
    United States, 
    527 U.S. 373
    , 389 (1999).
    3. Applying Plain Error Review to Jury Instructions
    How sparingly should the power to correct an instruction error for which
    there was no objection be exercised? The Supreme Court’s answer to that question
    is straightforward: “It is the rare case in which an improper instruction will justify
    reversal of a criminal conviction when no objection has been made in the trial
    court.” 
    Jones, 527 U.S. at 389
    (quotation marks omitted).
    40
    USCA11 Case: 17-13455          Date Filed: 10/09/2020        Page: 41 of 55
    When we apply the plain error rule to jury instructions, we do not consider
    the asserted errors in isolation. Instead we “consider ‘the totality of the charge as a
    whole’ and determine ‘whether the potential harm caused by the jury charge has
    been neutralized by the other instructions given at the trial such that reasonable
    jurors would not have been misled by the error.’” United States v. Whyte, 
    928 F.3d 1317
    , 1332 (11th Cir. 2019) (quoting United States v. Duncan, 
    855 F.2d 1528
    , 1532 (11th Cir. 1988)); see also 
    Pepe, 747 F.2d at 675
    (“Jury instructions
    will not be reversed for plain error unless the charge, considered as a whole, is so
    clearly erroneous as to result in a likelihood of a grave miscarriage of justice . . . .”)
    (quotation marks omitted and emphasis added); Lamb v. Jernigan, 
    683 F.2d 1332
    ,
    1339 (11th Cir. 1982) (“[I]n determining the effect of an instruction on the validity
    of a conviction, a single instruction may not be judged in artificial isolation, but
    must be viewed in the context of the overall charge.”) (cleaned up). If another
    instruction the court gave neutralized the error, then it was not an error at all, let
    alone a reversible plain error.12
    12
    An instructional error that is cured by another instruction the court gave actually is not
    an error at all, let alone a plain one, because the charge as a whole does not misinform the jury or
    prejudice the defendant. See United States v. Shabazz, 
    887 F.3d 1204
    , 1220 (11th Cir. 2018)
    (“We must consider the jury charge as a whole, and we may reverse only if we are left with a
    substantial and ineradicable doubt as to whether the jury was properly guided in its
    deliberations.”) (quotation marks omitted); United States v. Seabrooks, 
    839 F.3d 1326
    , 1333
    (11th Cir. 2016) (“We review jury instructions to determine whether the instructions misstated
    the law or misled the jury to the prejudice of the objecting party.”) (quotation marks omitted).
    Nor does such an asserted “error” affect a defendant’s substantial rights. See 
    Whyte, 928 F.3d at 1333
    (“In the light of the entirety of the instructions given, the omission of the element of
    41
    USCA11 Case: 17-13455           Date Filed: 10/09/2020       Page: 42 of 55
    We also consider whether the prejudicial effect was minimized or
    neutralized by “the manner in which the case was tried,” Jones v. Smith, 
    772 F.2d 668
    , 673 (11th Cir. 1985), including the attorneys’ arguments and the court’s
    statements to the jury. See United States v. Seabrooks, 
    839 F.3d 1326
    , 1333 (11th
    Cir. 2016) (“[T]he Supreme Court has admonished that ‘in reviewing jury
    instructions, our task is also to view the charge itself as a part of the whole trial,’
    noting that ‘[o]ften isolated statements taken from the charge, seemingly
    prejudicial on their face, are not so when considered in the context of the entire
    record of the trial.’”) (second alteration in original) (quoting United States v. Park,
    
    421 U.S. 658
    , 675–76 (1975)); cf. United States v. Reed, 
    941 F.3d 1018
    , 1021
    (11th Cir. 2019) (“As the reviewing court, we may consult the whole record when
    considering the effect of any error on [the defendant’s] substantial rights.”)
    (cleaned up) (quoting United States v. Vonn, 
    535 U.S. 55
    , 59 (2002)); 
    Whyte, 928 F.3d at 1333
    (holding that an asserted jury instruction omission was not reversible
    plain error in part because the indictment, which was provided to the jury during its
    deliberations, contained the omitted element).
    a commercial sex-act from the numbered list did not constitute plain error. . . . [A]ny potential
    harm caused by failing to include the element in the numbered list was cured by providing the
    other instructions and the indictment to the jury.”); 
    Duncan, 855 F.2d at 1533
    (“Because the jury
    was instructed by the trial judge both at the beginning of the trial and in his final closing
    instructions that all of the essential elements of § 1201 had to be proven, the defendant was not
    prejudiced by the asserted error in the jury charge. Any such error would be harmless in the
    context of this case.”).
    42
    USCA11 Case: 17-13455       Date Filed: 10/09/2020   Page: 43 of 55
    And even if the unobjected to error retained some prejudicial impact,
    reversal still may not be warranted. To show that an instructional error affected his
    substantial rights, a defendant must show that the error “was probably responsible
    for an incorrect verdict.” 
    Whyte, 928 F.3d at 1332
    (quoting Montgomery v. Noga,
    
    168 F.3d 1282
    , 1294 (11th Cir. 1999)); accord Farley v. Nationwide Mut. Ins. Co.,
    
    197 F.3d 1322
    , 1330–31 (11th Cir. 1999) (stating that to be a reversible plain error,
    an instruction error “must be so prejudicial as to have affected the outcome of the
    proceedings,” and holding that the error did not because “[t]he record plainly
    shows that no dispute existed over” the element omitted from the instructions)
    (quotation marks omitted); see 
    Rodriguez, 398 F.3d at 1299
    (“The standard for
    showing [an effect on substantial rights] is the familiar reasonable probability of a
    different result formulation, which means a probability sufficient to undermine
    confidence in the outcome.”) (quotation marks omitted).
    If the defendant’s guilt would have been clear under the correct instruction,
    he loses under the substantial rights third prong of plain error review because he
    has failed to carry his burden of showing a reasonable probability of a different
    result but for the error. See United States v. Barrington, 
    648 F.3d 1178
    , 1193–94
    (11th Cir. 2011); 
    Rodriguez, 398 F.3d at 1299
    . And he also loses under the fourth
    prong. See Johnson v. United States, 
    520 U.S. 461
    , 469–70 (1997); United States
    v. Vernon, 
    723 F.3d 1234
    , 1263 (11th Cir. 2013) (citing 
    Johnson, 520 U.S. at 470
    ).
    43
    USCA11 Case: 17-13455        Date Filed: 10/09/2020     Page: 44 of 55
    C. The Section 841(a)(1) Jury Instructions
    On Counts 2 through 4, Iriele contends that the district court failed to
    instruct the jury that to convict a pharmacist under § 841(a)(1) the government
    must prove the pharmacist knew that a physician issued the prescriptions without a
    legitimate medical purpose or outside the usual course of professional practice.
    Five times during its instructions on the standard for convicting pharmacists under
    § 841(a)(1), the district court stated either explicitly or implicitly that the question
    was whether the pharmacist (and not the prescribing physician) acted without a
    legitimate medical purpose or outside the usual course of professional practice.
    Iriele is right that the court did not correctly instruct the jury on the standard
    for convicting a pharmacist under § 841(a)(1). As we have already explained, see
    Part 
    IV.A.1, supra
    , our precedent establishes that “to convict a licensed pharmacist
    under section 841(a)(1), the government must prove that the pharmacist filled a
    prescription knowing that a physician issued the prescription without a legitimate
    medical purpose or outside the usual course of professional practice.” 
    Joseph, 709 F.3d at 1094
    . The district court never conveyed that requirement to the jury.
    Instead, it instructed the jury on the standard applicable to physicians as if it also
    applied to pharmacists. See
    id. (explaining that “[t]o
    convict a licensed physician
    under section 841(a)(1), it is incumbent upon the government to prove that he
    dispensed controlled substances for other than legitimate medical purposes in the
    44
    USCA11 Case: 17-13455         Date Filed: 10/09/2020       Page: 45 of 55
    usual course of professional practice, and that he did so knowingly and
    intentionally”) (cleaned up). Our decision in Joseph and the former Fifth Circuit’s
    decision in United States v. Hayes, 
    595 F.2d 258
    , 261 (5th Cir. 1979), make this
    instruction error plain. See 
    Frank, 599 F.3d at 1239
    (explaining that an error is
    plain if binding precedent “specifically resolve[s] the issue”).
    But those are only the first two plain error hurdles, and Iriele cannot clear
    the other two. The facts elicited at trial, which we have already discussed, see Part
    
    IV.A.1, supra
    , prove overwhelmingly that Iriele knew the AMARC defendants
    were issuing prescriptions without a legitimate medical purpose and outside the
    usual course of professional practice, which is the required standard. In light of
    that proof, Iriele has not shown that the asserted error “was probably responsible
    for an incorrect verdict.” 
    Whyte, 928 F.3d at 1332
    . He has not undermined our
    confidence in the outcome. And for the same reason, Iriele cannot show that the
    district court’s error seriously affected the fairness, integrity, or public reputation
    of judicial proceedings. See 
    Johnson, 520 U.S. at 469
    –70. 13
    13
    The government asserts, for the first time on appeal, that the standard applicable to
    pharmacists under § 841(a)(1) does not apply to Iriele because at the time of the relevant events
    his pharmacy license had been revoked. As a result, Iriele could not legally dispense controlled
    substances for any purpose. In the government’s view, that means Iriele was not entitled to an
    instruction on the standard for convicting a pharmacist under § 841(a)(1). We need not decide
    whether the government is right about that because even assuming, as we do, that Iriele should
    have been measured by the standard applicable to pharmacists, his argument fails.
    45
    USCA11 Case: 17-13455           Date Filed: 10/09/2020   Page: 46 of 55
    D. The Money Laundering Jury Instructions
    Count 23 charged Iriele with violating § 1956(h) by conspiring to commit
    money laundering and Counts 24 through 26 charged Iriele with violating § 1957
    by committing the substantive offense of financial transaction money laundering.
    Iriele contends that the district court “erred by entirely failing to instruct the jury”
    on § 1956(h) and § 1957. His statement of the issue is not totally accurate, but it’s
    not that far off, either — the district court’s instructions briefly described the
    § 1956(h) and § 1957 charges, but the court failed to give the jury separate offense
    instructions containing the elements of each charge. But under plain error review,
    that was not a reversible plain error.
    1. Conspiracy to Commit Money Laundering
    In Count 23 the indictment charged Iriele with conspiring to commit
    promotional, financial transaction, concealment, and structuring money laundering
    in violation of § 1956(h). Iriele correctly points out that the district court did not
    separately instruct the jury on the elements of § 1956(h). Early in its instructions
    the court told the jury:
    Count 23 charges that [Iriele] knowingly conspired to conduct financial
    transactions affecting interstate commerce which involved the proceeds
    of the illegal distributing and dispensing of controlled substances
    outside the course of professional practice and for other than a
    legitimate medical purpose, to conceal and disguise the nature and
    source, ownership, and control of the proceeds of this unlawful activity,
    and to avoid a transaction reporting requirement under Federal law.
    Count 23 also charges that [Iriele] knowingly conspired to engage in
    46
    USCA11 Case: 17-13455       Date Filed: 10/09/2020   Page: 47 of 55
    monetary transactions, by, through, or to a financial institution,
    affecting interstate and foreign commerce in criminally derived
    property of a value greater than $10,000.00.
    The court also told the jury that Count 23 did not charge Iriele with committing a
    substantive offense, but instead with conspiring to commit an offense. Those were
    the only times the court in its jury instructions mentioned Count 23 or conspiracy
    to commit money laundering; the court never expressly set out the elements of the
    offense. But the jury instructions, when viewed as a whole, nonetheless conveyed
    almost everything Iriele wanted the jury to know about those elements.
    Iriele’s requested jury instruction on § 1956(h), which tracked the Eleventh
    Circuit Criminal Pattern Jury Instruction on that provision, contained the
    following: (1) a statement that it’s a federal crime to conspire to engage in money
    laundering; (2) a list of the elements of the substantive money laundering
    provisions in § 1956 and § 1957; (3) a definition of the word “conspiracy”; (4) an
    explanation that the government need not prove that all people named in the
    indictment were members of the conspiracy, that those who were members made
    any kind of formal agreement, or that the plan succeeded; (5) the elements of
    conspiracy; (6) a statement that a person can be a conspirator even if he did not
    know all the details of the unlawful plan, did not know all of the other
    coconspirators, or played only a minor role in the plan; and (7) a statement that a
    person is not guilty of conspiracy merely because he was present at the scene of an
    47
    USCA11 Case: 17-13455         Date Filed: 10/09/2020       Page: 48 of 55
    event, associated with certain people, or inadvertently acted to further the
    conspiracy. See 11th Cir. Crim. Pattern Jury Instructions O74.5 (2020). 14 (Notice
    that the law in omitted instruction points (1), (4), and (6) is entirely favorable to the
    government, not to Iriele.)
    Nearly all of those seven points of law were included somewhere in the jury
    instructions that were given. Item 1 was covered by the court’s explanation that
    Iriele had been charged with conspiracy to commit money laundering. That
    instruction would have informed a reasonable jury that conspiracy to commit
    money laundering is a federal crime.
    Items 3 through 7, the standard conspiracy instructions, were covered when
    the court instructed the jury on the charge of conspiracy to distribute a controlled
    substance. The court defined the term “conspiracy” as “an agreement by two or
    more persons to commit an unlawful act.” It explained that “[t]he Government
    does not have to prove that all of the people named in the indictment were
    members of the plan, or that those who were members made any kind of formal
    agreement,” or “that the conspirators succeeded in carrying out the plan.” The
    court also explained that “[a] person may be a conspirator even without knowing
    14
    We need not, and do not, decide whether all of those instructions are necessary to
    properly instruct a jury on § 1956(h). But they are sufficient. Cf. United States v. Horner, 
    853 F.3d 1201
    , 1210 (11th Cir. 2017) (holding that a particular instruction, which was based on the
    Eleventh Circuit Criminal Pattern Jury Instructions, was a correct statement of the law but was
    not the only correct way to instruct a jury on the relevant offense).
    48
    USCA11 Case: 17-13455          Date Filed: 10/09/2020        Page: 49 of 55
    all the details of the unlawful plan or the names and identities of all the other
    alleged conspirators.” 15 A reasonable jury could have inferred from the elements
    of conspiracy to distribute a controlled substance that the elements of conspiracy to
    commit money laundering are similar: that there was an unlawful plan made by
    two or more people, and that the defendant knew of and participated in that plan.
    The court did expressly instruct the jury on the elements of promotional
    money laundering, concealment money laundering, and structuring money
    laundering, covering most of item 2. As a result, the court’s omission of a separate
    instruction on § 1956(h) was mostly cured by other instructions the court gave.
    See 
    Whyte, 928 F.3d at 1332
    –33.
    The district court did not, however, completely cover item 2. As we will
    discuss soon, the court did not convey to the jury everything the Eleventh Circuit
    Criminal Pattern Jury Instructions say about the elements of financial transaction
    money laundering. See Part V.D.2, infra. But Iriele has not shown that the court’s
    failure to do so affected his substantial rights. He hasn’t shown a reasonable
    probability that the asserted error affected the outcome of the proceedings –– he
    15
    Even if the court hadn’t explained those points about what the government need not
    prove and what a conspirator need not know, Iriele couldn’t complain about the court’s
    omissions because all of those instructions helped the government. Which means that by
    omitting them, the district court would have helped Iriele. Such an error could not have affected
    Iriele’s substantial rights. See 
    Rodriguez, 398 F.3d at 1300
    (“[I]f it is equally plausible that the
    error worked in favor of the defense, the defendant loses . . . .”); cf. United States v. Thomas, 
    8 F.3d 1552
    , 1563 n.24 (11th Cir. 1993) (“[A]ny error in the court’s instructions benefitted
    appellants and was therefore harmless.”).
    49
    USCA11 Case: 17-13455          Date Filed: 10/09/2020       Page: 50 of 55
    hasn’t undermined our confidence in the outcome of the trial. See 
    Farley, 197 F.3d at 1330
    (“[T]he error of law must be so prejudicial as to have affected the outcome
    of the proceedings.”) (quotation marks omitted); 
    Rodriguez, 398 F.3d at 1299
    (requiring a reasonable probability of a different result, meaning one sufficient to
    undermine our confidence in the outcome). The evidence at trial, which we have
    already discussed, see Part 
    IV.C, supra
    , proved overwhelmingly that Iriele
    conspired with Ofume to commit promotional money laundering. Iriele has failed
    to show a reasonable probability that he would not have been convicted of Count
    23 based on that evidence regardless of whether he also conspired to commit
    financial transaction money laundering. See 
    Feldman, 936 F.3d at 1307
    –08. He
    has failed to undermine our confidence in the outcome regarding Count 23. 16
    2. Financial Transaction Money Laundering
    Counts 24 through 26 charged Iriele with financial transaction money
    laundering in violation of § 1957. Those charges were based on Iriele’s use of
    MCP funds to purchase three luxury vehicles in his children’s names. Iriele argues
    16
    In addition to the court’s instruction on the elements of promotional money laundering,
    the government’s closing argument provided the jury with extra guidance on that crime. The
    government explained: “Promotion, that’s paying the pharmaceutical companies. . . . They paid
    the pharmaceutical companies for more pills to keep the pill mill churning.”
    It’s also worth mentioning that the government did not rely on a theory of financial
    transaction money laundering in arguing the conspiracy charge to the jury; instead, it relied on
    theories of promotional, concealment, and structuring money laundering. All of those factors
    suggest that the district court’s failure to give a complete instruction on financial transaction
    money laundering did not affect Iriele’s substantial rights. See 
    Reed, 941 F.3d at 1021
    (we may
    consult the entire record when gauging the effect, if any, of an error on the outcome of the trial).
    50
    USCA11 Case: 17-13455        Date Filed: 10/09/2020    Page: 51 of 55
    that the district court did not instruct the jury separately on financial transaction
    money laundering, and he’s right. The only mention of the financial transaction
    money laundering charges came early in the court’s jury instructions, when the
    court said: “Counts 24, 25, [and] 26 charge that [Iriele] knowingly engaged in a
    monetary transaction affecting interstate commerce and foreign commerce in
    criminally derived property that was of a value greater than $10,000.00.” As with
    Count 23, the court never separately and expressly set out the elements of the
    relevant crime. But as with Count 23, that omission was not reversible plain error.
    Iriele’s requested instruction on § 1957, which tracked the Eleventh Circuit
    Criminal Pattern Jury Instruction on that provision, contained the following: (1) a
    statement that it’s a federal crime to engage in money laundering; (2) the elements
    of financial transaction money laundering, which we will discuss below;
    (3) definitions of the terms “monetary transaction,” “financial institution,” and
    “proceeds”; (4) a statement that it doesn’t matter whether the defendant knew the
    precise nature of the crime the property was derived from, so long as he knew that
    the property was derived from committing some crime; and (5) an explanation that
    it doesn’t matter whether all of the property involved was criminally derived, as
    long as at least $10,000 worth was. See 11th Cir. Crim. Pattern Jury Instructions
    O74.6 (2020).
    51
    USCA11 Case: 17-13455       Date Filed: 10/09/2020    Page: 52 of 55
    Nearly all of those points of law were included somewhere in the district
    court’s jury instructions. We will start with items 1, 3, and 4, which the district
    court’s jury instructions actually did cover. As to item 1, the court told the jury in
    its instructions on other forms of money laundering that it’s a federal crime to
    engage in money laundering. As to item 3, the court expressly defined “financial
    institution” and “proceeds” at different places in the jury instructions. And
    although the court did not expressly define the term “monetary transaction” for the
    jury, its explanation of Count 23 essentially defined that term. A “monetary
    transaction” is a deposit, withdrawal, transfer, or exchange of funds “by, through,
    or to a financial institution in a way that affects interstate commerce.” 11th Cir.
    Crim. Pattern Jury Instructions O74.6 (2020). The court conveyed that idea when
    it instructed the jury that Count 23 charged Iriele with conspiring to, among other
    things, “engage in monetary transactions, by, through, or to a financial institution,
    affecting interstate and foreign commerce.” (Emphasis added.) And item 4 was
    covered by the court’s instructions on other forms of money laundering, which
    stated that Iriele need have known only that the property involved in the
    transaction was derived from committing some crime, even if he did not know
    what specific crime it was derived from.
    Item 2 involves the substantive elements of financial transaction money
    laundering. Those elements are: (a) the defendant knowingly engaged or
    52
    USCA11 Case: 17-13455           Date Filed: 10/09/2020          Page: 53 of 55
    attempted to engage in a monetary transaction; (b) the defendant knew the
    transaction involved property or funds that were the proceeds of some criminal
    activity; (c) the property had a value of more than $10,000; (d) the property was in
    fact proceeds of the unlawful distribution of controlled substances; and (e) the
    transaction took place in the United States. 11th Cir. Crim. Pattern Jury
    Instructions O74.6 (2020).
    The court told the jury the following about financial transaction money
    laundering: “Counts 24, 25, [and] 26 charge that Defendant Donatus Iriele
    knowingly engaged in a monetary transaction affecting interstate commerce and
    foreign commerce in criminally derived property that was of a value greater than
    $10,000.00.” That statement conveyed to the jury that to convict Iriele, it had to
    find that he knowingly engaged in a monetary transaction involving criminally
    derived property of a value greater than $10,000 — covering elements (a), (c), and
    (d).17 The court’s instructions on other forms of money laundering informed the
    17
    As if that weren’t enough, the government also presented an expert witness who
    discussed the different types of money laundering under the United States Code. The jury heard
    the following exchange:
    Q. Is there also a kind of money laundering that is done in violation of 1957? And
    if so, could you describe it to the jury?
    A. Okay. 1957 on your Title 18 is commonly referred to as financial transaction
    money laundering. And that is where a transaction has to exceed $10,000 and it’s
    conducted by, through or to a financial institution as defined by that statute. And
    financial institution under that statute . . . includes car dealers. . . . The key, again,
    53
    USCA11 Case: 17-13455            Date Filed: 10/09/2020       Page: 54 of 55
    jury that to prove Iriele knowingly engaged in a transaction involving criminally
    derived proceeds, the government had to prove both that the proceeds were
    actually criminally derived and that Iriele knew it. That covered element (b) and
    clarified what the court had said about element (d).
    The court did not, however, cover element (e), which is that the monetary
    transaction had to have taken place within the United States. See 18 U.S.C.
    § 1957(d). But that was not reversible plain error because Iriele has not shown that
    it affected his substantial rights. To the contrary, the evidence at trial established
    overwhelmingly Iriele’s guilt on the omitted element. Counts 24 through 26
    charged that Iriele had used money from the MCP bank account to purchase luxury
    vehicles in his children’s names. The government introduced wire transfer records
    showing that Iriele initiated those wire transfers in the United States and that the
    recipient car dealerships were also located in the United States. And Iriele did not
    dispute at trial whether the wire transfers were made in the United States. As a
    result, he has not shown that the court’s omission of one element from its
    is that the transaction has to exceed $10,000 and it has to travel to or come from or
    go through one of those financial institutions.
    Q. And does the $10,000 have to be in criminally-derived property?
    A. It does.
    The government correctly explained during its closing argument that the witness’s testimony
    about the law could not trump the district court’s instructions about the law. But to the extent the
    court’s jury instructions omitted any of the basics about financial transaction money laundering,
    the witness’s testimony could help fill in the gaps for plain error purposes.
    54
    USCA11 Case: 17-13455        Date Filed: 10/09/2020    Page: 55 of 55
    instruction on § 1957 affected his substantial rights or the fairness, integrity, or
    reputation of judicial proceedings. See 
    Johnson, 520 U.S. at 469
    –70; 
    Barrington, 648 F.3d at 1193
    –94.
    Finally, there is item 5. The court’s jury instructions did not tell the jury that
    it doesn’t matter whether all of the property involved in the alleged money
    laundering was criminally derived, as long as at least $10,000 worth of it was. But
    Iriele cannot complain about the court’s failure to give that instruction because the
    asserted error worked in his favor: the instruction, if given, would have helped the
    government. So if that was an error, it did not affect Iriele’s substantial rights; it
    affected the government’s rights. See 
    Rodriguez, 398 F.3d at 1300
    (“[I]f it is
    equally plausible that the error worked in favor of the defense, the defendant
    loses . . . .”); cf. United States v. Thomas, 
    8 F.3d 1552
    , 1563 n.24 (11th Cir. 1993)
    (“[A]ny error in the court’s instructions benefitted appellants and was therefore
    harmless.”).
    In summary, there were no preserved errors in the jury instructions and no
    unpreserved ones that meet the strictures of the plain error rule.
    VI. CONCLUSION
    For the reasons stated, we affirm the conviction.
    AFFIRMED.
    55