United States v. Lara ( 2022 )


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  • Case: 20-50112     Document: 00516162244         Page: 1   Date Filed: 01/11/2022
    United States Court of Appeals
    for the Fifth Circuit                         United States Court of Appeals
    Fifth Circuit
    FILED
    January 11, 2022
    No. 20-50112                   Lyle W. Cayce
    Clerk
    United States of America,
    Plaintiff—Appellee,
    versus
    Mary Ann Lara; Melissa Janet Lara,
    Defendants—Appellants.
    Appeal from the United States District Court
    for the Western District of Texas
    USDC No. 2:18-CR-859-2
    Before King, Higginson, and Wilson, Circuit Judges.
    Stephen A. Higginson, Circuit Judge:
    Sisters Mary Ann Lara and Melissa Lara were convicted by a jury of
    various drug trafficking counts after attempting to drive a pickup truck
    containing over 38 kilograms of methamphetamine hidden in a compartment
    in the truck’s tires from Mexico into the United States. They were sentenced
    to 288 months’ imprisonment. They each raise numerous issues on appeal.
    For the following reasons, we AFFIRM.
    Case: 20-50112     Document: 00516162244          Page: 2   Date Filed: 01/11/2022
    No. 20-50112
    I.
    A.
    On April 11, 2018, Priscilla Ramirez and her two daughters
    approached the Eagle Pass, Texas border checkpoint, driving a black
    Trailblazer. At primary inspection, Customs and Border Protection Officer
    Emily Vasquez questioned Ramirez about her trip to Mexico. Officer
    Vasquez stated that Ramirez gave no direct answers, seemed nervous, would
    not make eye contact, and looked back in the rearview mirror quite a few
    times. Ramirez denied traveling with anyone else. Ramirez told Officer
    Vazquez that the purpose of her trip was to visit a friend. Officer Vasquez
    noted that Ramirez had travelled all the way from San Antonio and had
    remained in Mexico for a very short amount of time. Officer Vasquez sent
    Ramirez to the secondary inspection area for a more intensive screening.
    The next vehicle to come through Officer Vasquez’s lane at the
    checkpoint was a silver Ford F-150 truck containing Mary Ann Lara, Melissa
    Lara, and a child. The Laras’ itinerary was exactly the same as Ramirez’s.
    Officer Vasquez recalled that she did not get any “straight answers” from
    either Mary Ann Lara or Melissa Lara. Additionally, the truck’s license plate
    returned a “text hit,” indicating that a full inspection on the vehicle was
    necessary. Accordingly, Officer Vasquez referred Mary Ann Lara and
    Melissa Lara to secondary inspection.
    Ramirez, Mary Ann Lara, Melissa Lara, and the children exited the
    vehicles for the secondary inspection, and Customs and Border Protection
    Officer Leonardo Lopez escorted them inside to a waiting area. He asked if
    Ramirez, Mary Ann Lara, and Melissa Lara were related, and they said no.
    He told them that they “look like sisters,” but they did not respond. Once
    the women and children were inside, Officer Lopez visually inspected the
    truck. He noted that it was “abnormally” clean inside, which is a “red flag.”
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    After the inspection, an x-ray machine indicated anomalies inside the tires.
    These anomalies were compartments containing methamphetamine.
    Laboratory testing indicated that the methamphetamine was 97% pure and
    had a net weight of 38.2 kilograms. No contraband was found in Ramirez’s
    vehicle.
    While in the waiting area, Ramirez, Mary Ann Lara, and Melissa Lara
    were separated, and their unlocked cell phones were taken by an officer.
    Ramirez and the Lara sisters indicated that they were traveling separately,
    and they acted like they did not know each other. After a little while, however,
    their children started talking and sharing Cheetos. The officers again asked if
    Ramirez and the Lara sisters knew each other, and they said “no.”
    Eventually, the children started playing with each other, and at that time
    Ramirez and the Lara sisters admitted to knowing each other. The Lara
    sisters and Ramirez were subsequently arrested.
    Mary Ann Lara, Melissa Lara, and Ramirez were ultimately charged
    as co-defendants, along with another woman named Ashley Trinidad.
    Ramirez pleaded guilty to conspiracy to tamper with a witness (for a
    confrontation with Trinidad in a detention center). Trinidad pleaded guilty
    to conspiracy to import methamphetamine. Mary Ann Lara and Melissa Lara
    pleaded not guilty and proceeded to trial.
    B.
    At the trial, Priscilla Ramirez testified that she knew Mary Ann Lara
    and Melissa Lara through their older sister, Carla Lara. Mary Ann Lara
    contacted Ramirez on Facebook, asking for a ride to Mexico to pick up a work
    truck from Rogelio Flores, Carla Lara’s ex-husband. Mary Ann Lara told
    Ramirez that she would pay Ramirez $200 to bring her to Mexico to pick up
    the truck.
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    A Facebook Messenger transcript showed that Flores contacted Mary
    Ann Lara on April 10, 2018, asking her if she knew anyone who could drive a
    truck from Nava, Mexico to San Antonio, Texas as soon as possible. He
    offered to pay $600 plus expenses. Mary Ann Lara asked Flores what was in
    the truck, and he responded, “right now nothing it’s clean.” He also told her
    that the truck was not stolen. He told her to erase all their messages more
    than once. Mary Ann Lara told Flores that Ramirez would pick up the truck,
    that she would accompany Ramirez, and that she would message him later on
    WhatsApp. Flores would not give Mary Ann Lara an address to pick up the
    truck but rather stated that once she and Ramirez had arrived in Nava, he
    would take them to the truck. Similarly, he did not give an address at which
    to drop off the truck in San Antonio. Later in that Messenger conversation,
    Mary Ann Lara asked Flores if they could leave the next day because Ramirez
    needed to fix her tire. Flores responded that it was urgent that the truck be
    driven to San Antonio, and he said that he would fix the tire or send them
    additional money to fix the tire. Mary Ann Lara asked Flores not to tell
    anyone that they were coming to get the truck; he responded that “nobody
    will know about this seriously.” The next morning, Mary Ann Lara told
    Flores that she and Ramirez had left for Mexico. Mary Ann Lara then
    exchanged two Facebook audio calls with Flores. After the calls, Mary Ann
    Lara told Flores on Messenger that she had brought Melissa Lara and “the
    baby” and that she had told Melissa Lara “not to say anything.”
    Ramirez testified that she drove Mary Ann Lara, Melissa Lara, Carla
    Lara’s son, and her own two daughters to Nava, Mexico on April 11, 2018.
    She stated that they were receiving directions from Flores and that Flores’
    cousin was requesting updates on their trip down to Mexico. Ramirez further
    testified that once they arrived in Mexico, they met Flores at a gas station and
    followed him to get something to eat and then to a house. After waiting at the
    house for over 20 minutes, an old man delivered the truck. The old man gave
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    money and the keys to the truck to Flores, who in turn gave them to Mary
    Ann Lara. Melissa Lara drove the truck back to Texas. Because the Lara
    sisters did not know their way back to the border, they followed Ramirez.
    Ramirez had to slow down to allow the Laras to keep up with her.
    The Facebook Messenger transcript showed that Mary Ann Lara and
    Flores were in communication during the drive to Mexico, with Flores giving
    directions and asking for updates. During the drive home, Flores told Mary
    Ann Lara that the truck would run back and forth between Mexico and Texas.
    Mary Ann Lara then told Flores that the license plate was expired. Flores told
    Mary Ann Lara to tell the checkpoint officers that the truck belonged to an
    aunt or a friend and that they came to Mexico to allow Carla Lara’s son to see
    his dad.
    Ramirez testified that she began to drive faster once she neared the
    border, because she was “thinking of [her] kids.” Ramirez said that she was
    nervous at the primary checkpoint because her daughter got out of her car
    seat. She admitted to falsely telling the border patrol officer that she was
    traveling alone, explaining that she did not acknowledge knowing the Lara
    sisters because she “thought it was best to keep quiet, it would be faster.”
    After the border patrol agents discovered the drugs in the truck, Ramirez was
    taken into custody.
    The last Facebook message from Mary Ann Lara to Flores indicated
    that the Lara sisters were in line at the checkpoint. Flores asked whether they
    were able to cross with the expired license plate, but Mary Ann Lara did not
    respond. Flores continued to message Mary Ann Lara, telling her that he was
    worried that she was not responding.
    Bjorn Schreiner, a special agent with Homeland Security
    Investigations, testified that on April 11, 2018 (the day the Laras were
    stopped at the border), Melissa Lara agreed to call Flores while agents
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    monitored and recorded the call. Agents instructed Melissa Lara to tell
    Flores that the truck had broken down somewhere between Eagle Pass and
    LaPryor and to ask him if he would come to get it. Agents believed that the
    truck breaking down was a logical story because Melissa Lara had told them
    that the truck was “driving funny and shaking really bad.” Although Melissa
    Lara eventually told Flores that the truck broke down, she began the call by
    saying, “Why didn’t you tell me the truck had drugs in it?” Agent Schreiner
    stated that as an investigative strategy, agents would not tell the target of a
    call that the drugs had been found. Informing Flores that the drugs had been
    found would likely interfere with the agents’ plan to get Flores to meet them
    off-site.
    Customs and Border Protection Officer Hector Hernandez testified
    regarding Ashley Lynn Trinidad’s arrest. On April 18, 2018, one week after
    the Lara sisters were arrested, Trinidad approached the Del Rio Port of
    Entry, driving a silver Expedition. Based on her itinerary and story, Officer
    Hernandez directed her to the secondary inspection area. At secondary
    inspection, they found her tires loaded with methamphetamine. Laboratory
    testing indicated that the methamphetamine was 95% pure and had a net
    weight of 38.9 kilograms. Trinidad was ultimately charged along with the
    Lara sisters and Ramirez.
    Trinidad testified that she is a close friend of Carla Lara. She stated
    that Carla Lara asked her to find someone to drive a truck to Piedras Negras,
    Mexico and back on the same day for $300. Trinidad agreed to drive the truck
    herself because she needed the money. After she repeatedly asked Carla Lara
    about the contents of the car, Lara told her that the car contained a kilogram
    of cocaine. At one point following their arrests, Trinidad, Ramirez, Mary
    Ann Lara, and Melissa Lara were all housed at the same detention center.
    While there, Ramirez and the Laras confronted Trinidad after Ramirez
    learned that Trinidad had cooperated with law enforcement. Ramirez told
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    Trinidad that she needed to “watch [her] back.” Mary Ann Lara asked
    Trinidad why she would cooperate with the Government and stated that it
    was “not right, [her] snitching.” Melissa Lara similarly asked Trinidad why
    she was cooperating.1
    Border Patrol Intelligence Agent Gerardo Huerta testified as an expert
    regarding methods of operation unique to drug trafficking organizations,
    based on the hundreds of load driver interviews he has conducted and
    hundreds of load driver reports he has reviewed. He stated that drug
    trafficking organizations use the same tactics and procedures. They recruit
    drivers who are unemployed, and they send them to Mexico to pick up
    vehicles to bring to the United States. Drivers are at the lowest level of the
    organization. The load drivers he interviewed usually knew that they were
    transporting narcotics, but they did not know the location, type of
    compartment, or the amount of narcotics they were transporting. Some
    drivers he interviewed, however, did not know what was in the vehicle they
    were transporting. Based on his interviews, Agent Huerta stated that the
    drivers who lied to agents usually knew that they were carrying something
    illegal. Typically, drivers are given a partial payment when they pick up the
    vehicle, to cover gas, food, and lodging. They receive final payment once the
    narcotics are delivered in the United States. Drivers often communicate with
    other players in the organization via WhatsApp and Facebook, because it is
    harder for law enforcement agencies to retrieve the information from these
    applications. Some drivers bring children to distract border patrol agents.
    Agent Huerta also explained that in 2018 he had identified a common
    characteristic among certain vehicle seizures that led to the identification of
    1
    Ramirez pleaded guilty to witness tampering based on this incident. When
    Ramirez testified at the Laras’ trial, however, she contradicted the factual basis of her plea,
    and the Government impeached her.
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    a drug-trafficking organization out of Nava, Mexico. The vehicles all
    transported 30 to 40 kilograms of methamphetamine, using a compartment
    that was built into the wheels. Agent Huerta further testified that the street-
    level value of the methamphetamine found in the truck that Melissa Lara was
    driving was $7.4 million.
    C.
    Mary Ann Lara and Melissa Lara were each charged with five counts:
    1. Conspiracy to possess with intent to distribute 500g or
    more of methamphetamine, in violation of 
    21 U.S.C. §§ 841
    (a)(1), (b)(1)(a), and 846;
    2. Possession with intent to distribute 500g or more of
    methamphetamine, 
    id.
     § 841(a)(1), (b)(1)(a);
    3. Conspiracy to import methamphetamine, id. §§ 952(a),
    960(a)(1), (b)(1), and 963;
    4. Importation of methamphetamine, id. §§ 952(a) and
    960(a)(1), (b)(1);
    5. Witness tampering, in violation of 
    18 U.S.C. § 1512
    (b)(3),
    (k).
    At the close of the Government’s case, Mary Ann Lara and Melissa Lara both
    moved for a judgment of acquittal pursuant to Federal Rule of Criminal
    Procedure 29. The court denied both motions. The jury ultimately convicted
    Mary Ann Lara of counts one through four but acquitted her on count five
    and convicted Melissa Lara of counts two through four but acquitted her on
    counts one and five.
    The Sentencing Guidelines calculation for both Laras was the same.
    Each received a total offense level of 42, with a guidelines range of 360
    months to life imprisonment. The district court downwardly varied and
    sentenced each sister to 288 months’ imprisonment. Both Mary Ann Lara
    and Melissa Lara appealed.
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    II.
    On appeal, Mary Ann Lara and Melissa Lara both raise the following
    four issues: whether the district court erred in denying their Rule 29 motions;
    whether the district court erred by allowing the Government to elicit
    improper expert testimony from a Border Patrol agent, contrary to the
    court’s own pre-trial order; whether the Government impermissibly
    commented on the Laras’ silence in its opening and closing arguments; and
    whether the Government improperly alluded to evidence not in the record
    during its closing argument.
    A.
    The Laras contend that the district court erred in denying their Rule
    29 motions. They challenge only the knowledge element of their respective
    convictions, arguing that the evidence presented at trial was insufficient for
    a rational juror to find either (1) that they had knowledge that a controlled
    substance was hidden in the truck or (2) that they had knowingly entered into
    an agreement to traffic drugs.2
    We review challenges to the sufficiency of the evidence as follows:
    Where . . . a defendant has timely moved for a judgment of
    acquittal, this court reviews challenges to the sufficiency of the
    evidence de novo. Though de novo, this review is nevertheless
    highly deferential to the verdict. Because of the shortcomings
    inherent in examining a cold appellate record without the
    benefit of the dramatic insights gained from watching the trial,
    we review the evidence and all reasonable inferences in the
    2
    Mary Ann Lara also raises the argument that even if there were evidence that she
    had knowledge that some sort of controlled substance was in the truck, the evidence was
    insufficient to prove that she had knowledge of the drug type and the drug quantity.
    However, she correctly concedes that this argument is foreclosed by our decision in United
    States v. Betancourt, 
    586 F.3d 303
     (5th Cir. 2009), and asserts it to preserve the issue.
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    light most favorable to the prosecution and to determine
    whether any rational trier of fact could have found the essential
    elements of the crime beyond a reasonable doubt.
    United States v. Delgado, 
    984 F.3d 435
    , 446 (5th Cir. 2021) (quoting United
    States v. Nicholson, 
    961 F.3d 328
    , 338 (5th Cir. 2020)).
    To convict Mary Ann Lara and Melissa Lara of Counts 2 and 4, the
    Government was required to prove that each knowingly possessed and
    imported a controlled substance. See United States v. Lopez-Monzon, 
    850 F.3d 202
    , 206 (5th Cir. 2017) (explaining that possession with intent to distribute
    requires “knowledge” and that importation of a controlled substance
    requires knowledge both that “the substance was controlled” and that “the
    substance would enter the United States” (first quoting United States v.
    Patino-Prado, 
    533 F.3d 304
    , 309 (5th Cir. 2008); and then quoting United
    States v. Moreno, 
    185 F.3d 465
    , 471 (5th Cir. 1999))). On the conspiracy
    counts, the Government had to prove “(1) the existence of an agreement to
    import or to possess with intent to distribute; (2) knowledge of the
    agreement; and (3) voluntary participation in the agreement.” United States
    v. Rodriguez-Mireles, 
    896 F.2d 890
    , 892 (5th Cir. 1990).
    “Knowledge of the presence of a controlled substance often may be
    inferred from the exercise of control over a vehicle in which the illegal
    substance is concealed.” United States v. Diaz-Carreon, 
    915 F.2d 951
    , 954
    (5th Cir. 1990). However, when the contraband was “smuggled in hidden
    compartments which were not clearly visible or readily accessible to the
    defendant,” “control of the vehicle . . . does not support an inference of
    guilty knowledge; it is at least a fair assumption that a third party might have
    concealed the controlled substances in the vehicle with the intent to use the
    unwitting defendant as the carrier in a smuggling enterprise.” 
    Id.
    Accordingly, in such cases, “this court ‘also require[s] circumstantial
    evidence that is suspicious in nature or demonstrates guilty knowledge.’”
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    Lopez-Monzon, 850 F.3d at 206 (alteration in original); see also United States
    v. Rojas Alvarez, 
    451 F.3d 320
    , 334 (5th Cir. 2006) (“[W]here . . . the
    contraband was secreted in a hidden compartment, this court requires
    additional evidence to prove the knowing element, such as a consciousness
    of guilt, conflicting statements, or an implausible account of events.”).
    The question is how offense-specific this additional circumstantial
    evidence must be, if at all. The Laras argue that while the evidence may
    support the inference that they knew that there was something illegal about
    the operation to transport the truck from Mexico into the United States, it
    does not support the more specific inference that they knew about the
    existence of a controlled substance in the truck or that the conspiracy
    involved the trafficking of a controlled substance. If a defendant controls a
    vehicle with drugs in a hidden compartment and then engages in additional
    suspicious behavior that demonstrates a general consciousness of guilt but
    not necessarily specific knowledge of the presence of a controlled substance,
    is that enough evidence to sustain a conviction?
    Our hidden compartment cases often speak of the required
    consciousness of guilt in general terms and focus on suspicious behavior that
    is not offense-specific. These cases have emphasized lies and inconsistent
    statements. For example, in Lopez-Monzon we described inconsistent
    statements and “attempts to mislead” investigators as “circumstantial
    evidence of ‘consciousness of guilt.’” 850 F.3d at 207 (quoting Rojas Alvarez,
    
    451 F.3d at 334
    ). Similarly, we explained in Diaz-Carreon that “[a]n
    implausible account of exculpatory events suggests that the defendant desires
    to obscure his criminal responsibility” and concluded that such an “account
    provides   persuasive    circumstantial    evidence    of   the   defendant’s
    consciousness of guilt.” 
    915 F.2d at 955
    . And in United States v. Gutierrez-
    Farias, we noted “the incompleteness of [the defendant’s] answers when
    asked where he picked up the tractor, and where he was taking it” and held
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    that “[b]ased on [the defendant’s] demeanor at the checkpoint and the
    vagueness of his answers, the jury could have inferred that he knew the
    marijuana was in the tires but was trying to hide that fact.” 
    294 F.3d 657
    , 660
    (5th Cir. 2002); see also United States v. Casilla, 
    20 F.3d 600
    , 603 (5th Cir.
    1994) (“Evasive and erratic behavior may be evidence of guilty
    knowledge.”); United States v. Richardson, 
    848 F.2d 509
    , 513 (5th Cir. 1988)
    (“[A] less-than-credible explanation is part of the overall circumstantial
    evidence from which possession and knowledge may be inferred.” (cleaned
    up)). Thus, control over a vehicle containing hidden drugs plus evidence of
    the defendant’s general consciousness of guilt is enough to prove the
    “knowledge” element of the possession with intent to distribute and
    importation of a controlled substance offenses.
    In this case, the record contains ample evidence of the Laras’ general
    consciousness of guilt. To list just some of the evidence: after Flores offered
    (via Facebook Messenger) to pay Mary Ann Lara $600 to drive the truck
    from Mexico to San Antonio but refused to tell her the addresses at which
    she would pick up and drop off the truck and told her to delete their messages,
    Mary Ann Lara told him not to “say anything to anyone” about the trip;
    Mary Ann Lara told Melissa Lara “not to say anything” when asking Melissa
    to accompany her on the trip; when the truck started “driving funny and
    shaking really bad” on the way back from Nava, Melissa Lara continued to
    drive, even though her young nephew was in the backseat without a car seat;
    when Mary Ann Lara asked Flores about the expired license plate, he told
    her to lie to checkpoint agents; at the Eagle Pass checkpoint, the Laras did
    not give Officer Vasquez any straight answers when asked about their
    itinerary; the sisters lied to officers about being related when they were
    initially detained; and Melissa Lara deviated from the script during her
    monitored call to Flores, potentially alerting him that the methamphetamine
    had been found. Additionally, once the jury reasonably inferred Mary Ann
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    Lara’s knowledge of the methamphetamine in the vehicle from her Facebook
    messages with Flores, it could have reasonably concluded that she would not
    put her sister in the position of unwitting drug smuggler. See United States v.
    Williams-Hendricks, 
    805 F.2d 496
    , 501 (5th Cir. 1986) (concluding that a
    father-son relationship supported a similar inference). Finally, the
    methamphetamine found in the truck’s tires had a street value of $7.4
    million. Given the money at stake, the jury reasonably could have inferred
    that Mary Ann Lara and Melissa Lara were not unwitting accomplices. See,
    e.g., United States v. Del Aguila-Reyes, 
    722 F.2d 155
    , 157 (5th Cir. 1983);
    United States v. Villarreal, 
    324 F.3d 319
    , 324 (5th Cir. 2003); Lopez-Monzon,
    850 F.3d at 209.3
    In light of the foregoing, a rational jury could have found that Mary
    Ann Lara and Melissa Lara knowingly possessed and imported a controlled
    substance (counts two and four). Additionally, because Mary Ann Lara
    agreed with Flores that she would pick up the truck in Mexico and take it to
    San Antonio, where she would leave it for someone else to pick up, a rational
    jury could have found that she agreed to import a controlled substance (count
    three) and to possess a controlled substance with intent to distribute (count
    one). See United States v. Michelena-Orovio, 
    719 F.2d 738
    , 753-54 (5th Cir.
    1983) (“[A] defendant’s distribution of the contraband need not be made to
    the ultimate consumer in order to convict him of conspiracy to possess with
    intent to distribute; it may, in appropriate circumstances, be made to a
    coconspirator.”). And because Melissa Lara agreed both to accompany Mary
    Ann Lara to Mexico and to drive the truck back to San Antonio, a rational
    jury could have found that she agreed to import a controlled substance (count
    3
    Of course, “[t]he high volume and value of the drugs [is] not dispositive,” even
    though “it does present circumstantial evidence that [the defendants] knew about the
    methamphetamine.” Lopez-Monzon, 850 F.3d at 209.
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    three). We also note that the jury gave a particularized verdict, acquitting
    each sister of some charged conduct. Accordingly, the district court did not
    err by denying Mary Ann Lara and Melissa Lara’s motions for judgment of
    acquittal.
    B.
    The Laras argue that the district court erred by allowing the
    Government to elicit improper expert testimony from Border Patrol
    Intelligence Agent Gerardo Huerta. Specifically, they contend that a portion
    of Agent Huerta’s testimony improperly commented on the ultimate issue in
    the case: whether the Laras knew that there were drugs hidden in the tires of
    the truck.
    The relevant testimony is as follows:
    • [Government]: Okay. And how many load drivers have
    you interviewed over your career?
    • [Huerta]: Hundreds.
    • [Government]: And how many load driver reports have
    you reviewed in your career?
    • [Huerta]: Hundreds.
    • [Government]: Okay. Now, based on those interviews and
    that -- the reviews in the reports, generally how much did
    these load drivers know about the inner workings of the
    [drug trafficking organization]?
    • [Huerta]: Well, usually it’s -- they know they’re
    transporting narcotics, but they don’t know the location,
    the type of compartment, or the amount of -- of the
    narcotics they’re transporting.
    • [Government]: So, they don’t -- again, they don’t know
    what they’re trans -- they -- they know that there’s
    something in there, they don’t know what they’re
    transporting?
    • [Huerta]: Yes, sir.
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    Following this testimony, on cross-examination Agent Huerta agreed
    that drug-trafficking organizations do not always inform their drivers that
    vehicles contain contraband and that he was familiar with smuggling cases
    where the drivers did not know what they were transporting. None of the
    parties referenced any of the above testimony in their closing arguments.
    i.
    The parties contest the standard of review for this issue. Before trial,
    the Government gave notice that it intended to offer the expert testimony of
    Agent Huerta to address, in part, the techniques that drug trafficking
    organizations use to distribute narcotics, including “narcotics trafficking
    patterns and importation practices.” Citing United States v. Gutierrez-Farias,
    
    294 F.3d 657
     (5th Cir. 2002), both Laras filed pretrial motions in limine
    seeking to exclude any expert testimony that would impermissibly assert an
    opinion with respect to their knowledge of the presence of the drugs. During
    a pretrial conference, the district court granted the motions in limine with
    respect to that objection, assuring the Laras’ attorneys that it would not allow
    Agent Huerta to “give an opinion as to your clients’ state of mind.”
    Significantly, however, when Agent Huerta testified, neither Lara made a
    contemporaneous objection to the now-challenged portion of his testimony.
    Because the Laras failed to contemporaneously object, the Government
    argues that the admission of this testimony should be reviewed for plain error.
    The Laras argue that the district court’s ruling on their pretrial motion in
    limine preserved their objection, making abuse of discretion the appropriate
    standard.
    Federal Rule of Evidence 103(b) provides that “[o]nce the court rules
    definitively on the record—either before or at trial—a party need not renew
    an objection or offer of proof to preserve a claim of error for appeal.” As we
    explained in Mathis v. Exxon Corp., when this rule was adopted in 2000, it
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    No. 20-50112
    “changed the law that had prevailed in this circuit” regarding the
    preservation of evidentiary errors. 
    302 F.3d 448
    , 459 n.16 (5th Cir. 2002)
    (citing Fed. R. Evid. 103(a)).4 We had previously required parties to make
    contemporaneous objections at trial, even if they had made a pretrial
    objection to the admissibility of the challenged evidence. 
    Id.
     at 459 & n.16.
    But given the 2000 amendment to Rule 103, we held that “[a] pre-trial
    objection is sufficient to preserve [an evidentiary] error for appellate
    review,” regardless of whether the party objected at trial. 
    Id. at 459
    .
    Similarly, in United States v. Lucas, we held that “Lucas was not required to
    renew his objection to the . . . evidence at trial. . . . A pretrial motion in limine,
    objecting to the evidence, is enough.” 
    849 F.3d 638
    , 642 (5th Cir. 2017)
    (citing Mathis, 
    302 F.3d at 459
    ).
    One could read this language from Mathis and Lucas to suggest that
    the Laras preserved their objection to Agent Huerta’s testimony by obtaining
    a pretrial ruling on their motion in limine, despite failing to
    contemporaneously object to the testimony at trial. However, neither Mathis
    nor Lucas stated whether the district court had granted or denied the motion
    in limine. See Mathis, 
    302 F.3d at 459
    ; Lucas, 849 F.3d at 642-43. And, as the
    Advisory Committee Note accompanying the 2000 amendment to Rule 103
    makes clear, this distinction is important:
    If the court changes its initial ruling, or if the opposing party
    violates the terms of the initial ruling, objection must be made
    when the evidence is offered to preserve the claim of error for
    appeal. The error, if any, in such a situation occurs only when
    the evidence is offered and admitted. United States Aviation
    Underwriters, Inc. v. Olympia Wings, Inc., 
    896 F.2d 949
    , 956
    (5th Cir. 1990) (“[O]bjection is required to preserve error
    4
    The relevant provision was originally codified as part of Rule 103(a)(2); in 2011,
    it was recodified as Rule 103(b).
    16
    Case: 20-50112     Document: 00516162244            Page: 17   Date Filed: 01/11/2022
    No. 20-50112
    when an opponent, or the court itself, violates a motion in
    limine that was granted”).
    Fed. R. Evid. 103 advisory committee’s note to 2000 amendment
    (emphasis added).
    In accordance with this committee note, the Tenth Circuit has held
    that “where a ruling on a motion in limine is modified or violated, ‘[s]ince
    the error is not in granting or denying the motion in limine, but in admitting
    or excluding the evidence at trial, the motion in limine does not preserve this
    error.’” United States v. Fonseca, 
    744 F.3d 674
    , 684 (10th Cir. 2014) (quoting
    21 Charles A. Wright & Kenneth W. Graham, Federal
    Practice & Procedure § 5037.16 (2d ed. 2005)). As that court
    explained, when a party’s pretrial evidentiary objection is denied, it would be
    futile for that party to “continue making objections at trial.” Id. at 683.
    Indeed, “requiring the renewal of objections after a definitive ruling may be
    a needless provocation to the trial judge, not to mention a distracting
    interruption during the trial.” Id. (quoting United States v. Mejia-Alarcon, 
    995 F.2d 982
    , 986 (10th Cir. 1993)) (internal quotation marks omitted).
    “However, this reasoning seems inapplicable where evidence is admitted in
    spite of, rather than in accordance with, a district court’s ruling.” 
    Id.
     After
    all, in such cases, a contemporaneous objection does not “re-rais[e] an
    objection that ha[s] already been rejected.” 
    Id.
     Rather, it “put[s] the district
    court on notice” that the other party is “violating the court’s earlier
    evidentiary ruling.” Id.; cf. United States v. Soza, 
    874 F.3d 884
    , 889 (5th Cir.
    2017) (explaining that, in order to preserve an issue for appeal, the objecting
    party “must present the issue so that it places the opposing party and the
    [district] court on notice that a new issue is being raised” (quoting Kelly v.
    Foti, 
    77 F.3d 819
    , 823 (5th Cir. 1996)) (internal quotation marks omitted)).
    The Laras do not cite, and we have not identified, any cases holding
    that the rule set forth in Mathis applies regardless of whether the relevant
    17
    Case: 20-50112        Document: 00516162244               Page: 18       Date Filed: 01/11/2022
    No. 20-50112
    motion in limine was granted or denied. As already explained, Mathis and
    Lucas neither grapple with the distinction between granting and denying a
    pretrial objection nor state how the district court ruled. And in the cases
    applying Mathis where the district court’s ruling is identified, the relevant
    pretrial objection was denied. See, e.g., United States v. Lewis, 
    796 F.3d 543
    ,
    545 & n.6 (5th Cir. 2015); Carlson v. Bioremedi Therapeutic Sys., Inc., 
    822 F.3d 194
    , 198 (5th Cir. 2016); United States v. Avants, 
    367 F.3d 433
    , 443-44 (5th
    Cir. 2004); United States v. Ahedo, 453 F. App’x 544, 547 (5th Cir. 2011) (per
    curiam).5 Accordingly, Mathis and its progeny do not control this case. See
    Thomas v. Tex. Dep’t of Crim. Just., 
    297 F.3d 361
    , 370 n.11 (5th Cir. 2002)
    (“Where an opinion fails to address a question squarely, we will not treat it
    as binding precedent.”).
    Without any authority from our court that explicitly addresses this
    issue, we are persuaded by the reasoning of the Tenth Circuit and the
    Advisory Committee Note. When a district court grants a party’s pretrial
    evidentiary objection, that party must contemporaneously object to any
    evidence it believes contravenes the district court’s previous ruling. If the
    party does not object, the admission of that evidence is reviewed for plain
    error. See Avants, 
    367 F.3d at 443
     (“Evidentiary rulings are reviewed for
    abuse of discretion; however, in the absence of a proper objection, we review
    only for plain error.”).
    ii.
    Under plain error review, the appellant must show that: “(1) there was
    an error; (2) the error was clear or obvious; (3) the error affected his or her
    5
    Further, though neither Mathis nor Lucas states how the district court ruled on
    the relevant motion in limine, the circumstances of those cases suggest that in all likelihood
    the motions were denied. See Mathis, 
    302 F.3d at 459
    ; Lucas, 849 F.3d at 642-43.
    18
    Case: 20-50112      Document: 00516162244            Page: 19    Date Filed: 01/11/2022
    No. 20-50112
    substantial rights; and (4) the error seriously affects the fairness, integrity, or
    public reputation of judicial proceedings such that we should exercise our
    discretion to reverse.” United States v. Oti, 
    872 F.3d 678
    , 690 (5th Cir. 2017).
    a.
    Federal Rule of Evidence 704(b) states: “In a criminal case, an expert
    witness must not state an opinion about whether the defendant did or did not
    have a mental state or condition that constitutes an element of the crime
    charged or of a defense. Those matters are for the trier of fact alone.” Fed.
    R. Evid. 704(b). Accordingly, in drug trafficking cases, there is a “‘fine but
    critical line’ between ‘expert testimony concerning methods of operation
    unique to the drug business, and testimony comparing a defendant’s conduct
    to the generic profile of a drug courier.’” United States v. Sosa, 
    897 F.3d 615
    ,
    619 (5th Cir. 2018) (quoting United States v. Gonzalez-Rodriguez, 
    621 F.3d 354
    , 364 (5th Cir. 2010)). “A witness crosses this line by offering a direct
    opinion as to the defendant’s mental state or by giving the ‘functional
    equivalent’ of such a statement.” United States v. Morin, 
    627 F.3d 985
    , 995
    (5th Cir. 2010) (quoting Gutierrez-Farias, 
    294 F.3d at 663
    ).
    While Agent Huerta did not offer a direct opinion on either Lara’s
    mental state, the Laras argue that the challenged portion of his testimony is
    error under our decision in United States v. Gutierrez-Farias. In that case, the
    defendant was convicted of conspiracy and possession with intent to
    distribute marijuana after Border Patrol agents discovered marijuana hidden
    in the tires of a tractor he was towing. 
    294 F.3d at 659
    . At trial, the
    Government presented the expert testimony of DEA Agent Robert
    Afanasewicz. 
    Id. at 661
    . The defendant challenged “the portion of Agent
    Afanasewicz’s testimony in which he described the manner in which drug
    trafficking organizations generally select people to transport their drugs and
    the extent to which those selected are aware of the drugs they are
    19
    Case: 20-50112      Document: 00516162244           Page: 20   Date Filed: 01/11/2022
    No. 20-50112
    transporting,” arguing that “Agent Afanasewicz was really giving an opinion
    as to whether [the defendant] personally had knowledge of the marijuana in
    the tires.” 
    Id. at 661-62
    .
    We agreed. “Rather than assisting the jury to understand evidence
    presented or complicated fact issues in the case, Agent Afanasewicz
    presented the jury with a simple generalization: In most drug cases, the
    person hired to transport the drugs knows the drugs are in the vehicle.” 
    Id. at 663
    . Accordingly, his testimony was a “forbidden opinion on the ‘ultimate
    legal issue’ in the case.” 
    Id.
     (quoting United States v. Speer, 
    30 F.3d 605
    , 610
    (5th Cir. 1994)). Agent Afanasewicz might not have expressly said, “In my
    expert opinion, [the defendant] knew the marijuana was in the tires,” but we
    concluded that “his testimony amounted to the functional equivalent of such
    a statement.” Id.; see also United States v. Ramirez–Velasquez, 
    322 F.3d 868
    ,
    879 (5th Cir. 2003) (citing Gutierrez-Farias in determining that an expert
    agent improperly “made the generalization, albeit not quite directly, that
    drivers know they are carrying drugs”).
    Here, the Government acknowledges that Agent Huerta’s testimony
    “bears a resemblance to testimony that this Court has held to be the
    ‘functional equivalent’ of an improper opinion under Rule 704(b).”
    However, it argues that Agent Huerta’s testimony is ultimately
    distinguishable from Agent Afanasewicz’s testimony and the similar
    testimony at issue in Ramirez-Velasquez because, “[u]nlike those cases,
    Agent Huerta did not express the opinion that most drivers know or that [the
    Laras] knew” that their vehicles contained a controlled substance. Rather,
    his testimony “boiled down to ‘a lot of the time, the drivers know, but they
    don’t always.’” The Government also argues that the reach of Gutierrez-
    Farias has been limited by this court’s subsequent decision in United States
    v. Portillo, 
    969 F.3d 144
     (5th Cir. 2020), cert. denied, 
    141 S. Ct. 1275
     (2021).
    Accordingly, the Government maintains that while Agent Huerta’s
    20
    Case: 20-50112     Document: 00516162244           Page: 21   Date Filed: 01/11/2022
    No. 20-50112
    testimony is “arguably close to the line,” it cannot “be definitively
    characterized as ‘clear or obvious’ error.”
    The Government’s efforts to distinguish Gutierrez-Farias from this
    case are unpersuasive. Just like the agent in Gutierrez-Farias, Agent Huerta
    “described . . . the extent to which those selected [to transport drugs] are
    aware of the drugs they are transporting,” ultimately testifying that drug
    couriers “usually” know that they are transporting drugs. 
    294 F.3d at 661-62
    .
    Although neither Agent Huerta nor Agent Afanasewicz expressly opined on
    the mental state of the defendant, both gave the “functional equivalent” of
    such testimony. 
    Id. at 663
    . And while Agent Huerta did acknowledge during
    cross-examination that not all couriers know they are transporting drugs, this
    statement is simply consistent with his testimony that couriers “usually”
    know. Cf. 
    id. at 662
     (“The clear suggestion of Agent Afanasewicz’s
    testimony is that, because most drivers know there are drugs in their vehicles,
    [the defendant] must have known too.” (emphasis added)).
    We also reject the argument that Portillo limited the holding of
    Gutierrez-Farias. In Portillo, the defendant challenged the admissibility of
    expert testimony concerning the typical characteristics of the president of the
    Bandidos motorcycle gang. 969 F.3d at 171. Relying upon Gutierrez-Farias,
    the defendant, who was the president of the Bandidos at the time of the
    offense, contended that the testimony impermissibly communicated that he
    must have known about and participated in the offenses. Id. Citing another
    decision where expert testimony focused more on background than on the
    charged defendant’s culpability, the Portillo court suggested that the
    perceived inference of criminal scienter was too attenuated to violate the
    Rule 704(b) bar. Id. (citing United States v Morin, 
    627 F.3d 985
    , 996 (5th Cir.
    2010)). However, like Gutierrez-Farias, both Portillo and Morin acknowledge
    the caution necessary when expert testimony describes criminal
    organizations and “typical” positions in them, in order to avoid prohibited
    21
    Case: 20-50112      Document: 00516162244            Page: 22   Date Filed: 01/11/2022
    No. 20-50112
    mental-state opinion testimony. See Portillo, 969 F.3d at 171; Morin, 
    627 F.3d at 995-96
    . Further, rather than holding that it was not error to admit the
    challenged testimony, Portillo instead concludes that “[e]ven if” the district
    court erred, “any error was harmless.” 
    Id.
     Accordingly, to the extent that the
    Portillo court overbroadly described the ruling in Morin, its statements were
    dicta that do not call into doubt Gutierrez-Farias’s holding that the
    “functional equivalent” of a direct opinion on a defendant’s mental state
    violates Rule 704(b). 
    294 F.3d at 663
    ; see also 
    id.
     at 663 n.5 (acknowledging
    but distinguishing cases finding no Rule 704(b) error).
    Because Agent Huerta effectively testified that the Laras knew that
    drugs were hidden in the tires of the truck they were driving, the district
    court’s admission of that testimony was error under Federal Rule of
    Evidence 704(b). And because this case is indistinguishable from Gutierrez-
    Faria, the error was clear and obvious. Accordingly, the first two prongs of
    the plain error analysis are satisfied.
    b.
    To prevail under plain error review, an appellant must not only show
    that the district court committed a clear or obvious error but also that “the
    error affected his or her substantial rights.” Oti, 872 F.3d at 690. In order to
    show that the error affected their substantial rights, the Laras must
    demonstrate that there is “a reasonable probability that [their] trial would
    have come out differently but for the illegitimate aspects of Agent [Huerta’s]
    testimony.” Gonzalez-Rodriguez, 
    621 F.3d at 367
    . “This third requirement of
    plain-error review has prevented defendants from obtaining relief in [many]
    other cases involving improper drug profiling testimony.” Sosa, 897 F.3d at
    620 (collecting cases). The question of whether an error affected an
    appellant’s substantial rights is conceptually similar to the well-known
    “harmless error” inquiry, “with one important difference: It is the defendant
    22
    Case: 20-50112     Document: 00516162244           Page: 23   Date Filed: 01/11/2022
    No. 20-50112
    rather than the Government who bears the burden of persuasion with respect
    to prejudice.” United States v. Olano, 
    507 U.S. 725
    , 734 (1993).
    Ultimately, we conclude that Agent Huerta’s testimony did not affect
    the Laras’ substantial rights. For the reasons explained in supra Part II.A,
    even without Agent Huerta’s testimony, considerable evidence supported
    the jury’s verdict. Moreover, the jury was aware that Agent Huerta had never
    had “any direct conversations” with the Laras, and the court instructed the
    jury members that they should judge Agent Huerta’s testimony “like any
    other testimony” and that they could “accept it or reject it,” giving the
    testimony “as much weight as you think it deserves.” In similar
    circumstances, we have held that a defendant’s substantial rights were not
    affected. See Ramirez-Velasquez, 
    322 F.3d at 879
     (holding that a narcotics
    agent’s improper testimony did not affect the defendant’s substantial rights
    given both (1) the court’s instructions to the jury that the agent “was not
    claiming to know the particular facts of the case” and that “his testimony
    was to be weighed and could be disregarded like that of any other witness”
    and (2) “the other evidence . . . from which the jury could infer [the
    defendant’s] guilt”). The Government’s decision not to reference Agent
    Huerta’s testimony in its closing argument further suggests that this
    testimony was not crucial. Cf. Sosa, 897 F.3d at 620 (concluding that
    improper drug courier profile testimony was not plain error in part because
    the prosecutor did not “remind the jury of the agent’s improper testimony
    during closing argument”). We caution that under circumstances such as
    these, involving above all a violation of a pre-trial order, the Government
    would not be able to show that the error was harmless had an objection been
    preserved. However, considering that the Laras have not cited any cases or
    pointed to any facts in the record to support their argument that Agent
    Huerta’s testimony affected their substantial rights, we cannot say that they
    have met their plain error burden of demonstrating that “the inadmissible
    23
    Case: 20-50112      Document: 00516162244            Page: 24     Date Filed: 01/11/2022
    No. 20-50112
    profile testimony was likely the difference maker at trial.” Sosa, 897 F.3d at
    620. Accordingly, the Laras do not prevail on this issue under plain error
    review.
    C.
    “No person . . . shall be compelled in any criminal case to be a witness
    against himself.” U.S. Const. amend. V. Accordingly, if a defendant
    decides not to testify at trial, “[t]he Fifth Amendment forbids comment by
    the prosecution, either direct or indirect, on the accused’s silence.” United
    States v. Murra, 
    879 F.3d 669
    , 682 (5th Cir. 2018) (citing Griffin v. California,
    
    380 U.S. 609
    , 615 (1965)); see also United States v. Martinez-Larraga, 
    517 F.3d 258
    , 266 (5th Cir. 2008) (“[T]he Fifth Amendment’s self-incrimination
    clause . . . preclude[s] the prosecution from arguing to the jury that the
    accused’s failure to testify at the trial [is] evidence of his guilt.”).
    The Laras argue that the Government improperly commented on
    their choice not to testify in their own defense during its opening statement
    and closing argument. The Laras challenge the following remarks from the
    Government’s opening statement:
    At the end of the proceeding the judge is going to instruct you
    that you are to evaluate all the evidence in this case. You will
    evaluate with your own common sense and your own common
    experiences. And I want you to look at this evidence and I want
    you to ask: Why? Why would someone go to a -- to a town
    they’ve never been? Why would someone pick up a vehicle
    from a person they’ve never known? Why would someone get
    paid to do so? Why would someone continue driving when that
    vehicle’s shaking violently, can barely get above 50, can barely
    steer with a -- with a three-year-old in the car?
    Now, I suspect the defense is going to get up here and
    tell you the only crime that was committed by their clients is
    misplaced trust in an untrustworthy individual, [Flores]. While
    24
    Case: 20-50112        Document: 00516162244         Page: 25   Date Filed: 01/11/2022
    No. 20-50112
    I want you to -- when you hear that, I want you to just keep
    asking: Why? Why ignore the red flags? Even if -- even if you’re
    ostensibly trusting this guy, why ignore the alarm bells?
    They argue that this statement indirectly comments on their decision not to
    testify because only they could have answered the various questions that the
    Government asked.
    The Laras also challenge part of the Government’s closing argument:
    How can you tell what’s in someone’s mind? That’s
    what this entire case is about, right? You have no evidence of any
    statements from Ms. Mary Ann Lara or Ms. Melissa Lara. You
    just have their actions; what they did, what was happening, and
    some lies, but no direct statements. What was in their minds?
    Now, ladies and gentlemen, it -- it doesn’t take a rocket
    scientist to kind of piece together what’s happening. It doesn’t
    take a Border Patrol intel agent, it doesn’t take a Customs and
    Border Protection officer. It just takes some common sense.
    When you look at the facts in this case, your common
    sense will lead you to one conclusion. Mary Ann Lara and
    Melissa Lara were conspiring to bring in a controlled
    substance. They were importing it from Mexico into the
    United States and they were taking it to San Antonio so
    someone else could pick it up and it could be distributed.6
    They argue that the italicized portions of the first paragraph of this statement
    directly commented on their decision not to testify.
    When reviewing claims that a prosecutor improperly commented on
    a defendant’s decision not to testify, we must “first decide whether the
    prosecutor made an impermissible remark.” Murra, 879 F.3d at 682. If we
    conclude that the remark is impermissible, we must then determine
    6
    Emphasis added.
    25
    Case: 20-50112        Document: 00516162244        Page: 26   Date Filed: 01/11/2022
    No. 20-50112
    “whether the remark casts serious doubt on the correctness of the jury’s
    verdict.” Id. at 684 (cleaned up). Additionally, because, here too, the Laras
    “failed to object at trial,” they “bear[] the burden of demonstrating that the
    prosecutor’s statements constitute plain error.” United States v. Vargas, 
    580 F.3d 274
    , 278 (5th Cir. 2009); see also Oti, 872 F.3d at 690 (describing plain
    error review).
    The Government’s above-quoted remarks are impermissible under
    the Fifth Amendment’s Self-Incrimination Clause if either “the prosecutor’s
    manifest intent was to comment on the defendant’s silence” at trial or “the
    character of the remark was such that the jury would naturally and necessarily
    construe it as a comment on the defendant’s silence.” Murra, 879 F.3d at
    683. This test is strict. Regarding the first prong, “[i]f there is an ‘equally
    plausible explanation for the remark,’ the prosecutor’s intent is not
    manifest.” United States v. Green, 
    324 F.3d 375
    , 382 (5th Cir. 2003) (quoting
    United States v. Grosz, 
    76 F.3d 1318
    , 1326 (5th Cir. 1996)). Further, “[t]he
    defendant bears the burden of proving the prosecutor’s intent.” Murra, 879
    F.3d at 683. Regarding the second prong, “the question is not whether the
    jury possibly or even probably would view the challenged remark in this
    manner, but whether the jury necessarily would have done so.” United States
    v. Grosz, 
    76 F.3d 1318
    , 1326 (5th Cir. 1996) (citation omitted). When making
    these determinations, we must examine the prosecutor’s remarks “in
    context” rather than “isolation.” United States v. Weast, 
    811 F.3d 743
    , 753
    (5th Cir. 2016).
    The Government’s remarks in its opening statement were not
    constitutionally impermissible. In context, it does not seem likely that the
    prosecutor was intending to comment on the Laras’ decision not to testify.
    Rather, the Government was apparently providing a list of rhetorical
    questions for the jury to keep in mind when they evaluated the defendants’
    knowledge based on the evidence. An “attorney is entitled to urge the
    26
    Case: 20-50112      Document: 00516162244           Page: 27   Date Filed: 01/11/2022
    No. 20-50112
    conclusions which the attorney thinks the jury should draw from the
    evidence.” United States v. Allen, 
    588 F.2d 1100
    , 1108 (5th Cir. 1979). In
    doing so, the Government may utilize rhetorical questions that are
    “inferential in substance.” United States v. Sorzano, 
    602 F.2d 1201
    , 1202 (5th
    Cir. 1979). Such questions are not impermissible comments on a defendant’s
    right to remain silent. See 
    id.
    The Government’s remarks in its closing argument are more difficult.
    One could plausibly view the prosecutor’s assertions that “You have no
    evidence of any statements from Ms. Mary Ann Lara or Ms. Melissa Lara”
    and that the Laras made “no direct statements” as a comment on the Laras’
    decision not to testify. However, reviewing for plain error only, we pretermit
    confirming whether the challenged remarks were necessarily a comment on
    the Laras’ decisions not to testify, as opposed to part of an argument that
    even though the Government had not introduced any evidence showing that
    either Lara had ever made a single statement to law enforcement, Flores,
    Ramirez, or Trinidad directly indicating that she knew the truck contained
    methamphetamine, the jury should nonetheless infer their knowledge from
    circumstantial evidence. See United States v. Pando Franco, 
    503 F.3d 389
    , 394
    (5th Cir. 2007) (“[C]ircumstantial evidence is often used to establish the
    knowledge element for possession or importation of drugs.”); United States
    v. Zanabria, 
    74 F.3d 590
    , 593 (5th Cir. 1996) (“The [F]ifth [A]mendment
    protects against compelled self-incrimination but does not, as Zanabria
    suggests, preclude the proper evidentiary use and prosecutorial comment
    about every communication or lack thereof by the defendant which may give
    rise to an incriminating inference.”). Instead, we decide only that even if the
    Government erroneously commented on the Laras’ decision not to testify,
    the Laras have not met their plain error burden of showing that such an error
    was, in the context of a case built on circumstantial evidence rather than
    27
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    No. 20-50112
    direct admissions of guilt, both obvious and substantially prejudicial. See Oti,
    872 F.3d at 690.
    Of course, in addition to prohibiting comment on a defendant’s
    decision not to testify, the Constitution also prohibits prosecutors from
    commenting on a defendant’s silence in certain other contexts. The Laras
    briefly argue that even if the challenged remarks from the Government’s
    closing argument were not an impermissible comment on their decision not
    to testify, they were an impermissible comment on their post-arrest silence,
    in violation of Doyle v. Ohio, 
    426 U.S. 610
     (1976). Indeed, “the prosecution’s
    introduction at trial of evidence of the accused’s silence after being given
    Miranda warnings following arrest violates the due process clause.”
    Martinez-Larraga, 
    517 F.3d at
    266 (citing Doyle, 
    426 U.S. 610
    ) (emphasis
    omitted). However, in this case, both Laras voluntarily waived their Miranda
    rights and talked with law enforcement after their arrest. “[E]vidence of
    defendant’s silence and refusal to answer post-arrest questions is
    admissible” if it is “‘part of an otherwise admissible conversation’ pursuant
    to defendant’s Miranda waiver.” United States v. Pando Franco, 
    503 F.3d 389
    ,
    397 (5th Cir. 2007) (quoting United States v. Burns, 
    276 F.3d 439
    , 442 (8th
    Cir. 2002)). After all, “[a] defendant cannot have it both ways. If he talks,
    what he says or omits is to be judged on its merits or demerits, and not on
    some artificial standard that only the part that helps him can be later referred
    to.” 
    Id.
     (quoting United States v. Goldman, 
    563 F.2d 501
    , 503 (1st Cir. 1977)).
    Accordingly, the Government’s remarks did not violate Doyle.
    D.
    The Laras argue that during its rebuttal closing argument, the
    Government improperly alluded to evidence not in the record and implied
    that the Laras destroyed evidence. The Government responds that the
    28
    Case: 20-50112     Document: 00516162244           Page: 29   Date Filed: 01/11/2022
    No. 20-50112
    prosecutor’s remarks were a fair and direct response to defense counsel’s
    closing arguments.
    “A prosecutor may not directly refer to or even allude to evidence that
    was not adduced at trial.” United States v. Murrah, 
    888 F.2d 24
    , 26 (5th Cir.
    1989). Likewise, prosecutors “may not suggest that evidence which was not
    presented at trial provides additional grounds for finding defendant guilty.”
    United States v. Garza, 
    608 F.2d 659
    , 663 (5th Cir. 1979). Rather, prosecutors
    are “confined in closing argument to discussing properly admitted evidence
    and any reasonable inferences or conclusions that can be drawn from that
    evidence.” Vargas, 
    580 F.3d at 278
    . In doing so, a prosecutor may directly
    respond to theories of the evidence offered by defense counsel. See 
    id. at 279
    .
    And of course, as stated above, we examine a prosecutor’s allegedly improper
    remarks “in context” rather than “isolation.” Weast, 811 F.3d at 753.
    During closing arguments, defense counsel for Mary Ann Lara and
    defense counsel for Melissa Lara both argued that the Facebook Messenger
    transcript shows lack of knowledge of methamphetamine because the
    transcript shows that Flores repeatedly told Mary Ann Lara that nothing
    illegal was in the truck. Melissa Lara’s counsel also indicated that all the
    conversations between Mary Ann Lara and Flores were depicted in the
    Facebook Messenger transcript. In its rebuttal closing argument, the
    Government then made the following remarks:
    I want to make another point. We don’t know what was
    said between these individuals in person. We don’t know what
    was said between these individuals when they call each other
    on the telephone. There are even a couple of audio calls on the
    Facebook message. We don’t know what’s said then. We don’t
    know what was said in WhatsApp, but they sure went and
    talked there. She told him to.
    Why is that important? Because the information you
    have, government -- or the Defendant’s Exhibit Number One,
    29
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    No. 20-50112
    is a very small selection of Facebook messages that were pulled
    in February. There’s a date on there. February 2019. This
    happened in April of 2018. Those were the messages that still
    existed in Facebook on February of 2019. Those aren’t the
    whole story. They’re a good start and they still don’t show that
    the defendant had absolutely no knowledge. It shows that the
    defendant didn’t delete any messages when he’s saying, No,
    no, there’s nothing in the car. Don’t worry about it.
    But compare that to what Ashley Trinidad told you. She
    told you she asked Carla multiple times, [a]re there going to be
    drugs in the truck I’m taking? And Carla told her several times,
    [n]o. Before finally saying, [a]ll right, there’s one kilo of coke.
    Read those messages in progress -- progression just like
    defense asked you to. . . . You’ll see that after a while, the
    questions about what’s in the car stop. And it’s after they’ve
    picked up the truck and met with him for an hour and eight
    minutes in person, the truck the old man drops off and doesn’t
    talk to them about.
    The Laras argue that the prosecutor’s statement that the Facebook
    Messenger transcript admitted at trial was a “very small selection of
    Facebook messages that were pulled in February” implied that a larger
    selection of messages existed. They further argue that the prosecutor’s
    comparison of Mary Ann Lara’s conversation with Flores to Trinidad’s
    conversations with Carla Lara implied that these messages were
    incriminating. Finally, the Laras contend that the prosecutor’s remark, “It
    shows that the defendant didn’t delete any messages when [Flores is] saying,
    [n]o, no, there’s nothing in the car,” clearly implies that Mary Ann Lara or
    Melissa Lara deleted incriminating evidence.
    However, we read the above remarks as simply emphasizing that the
    Facebook Messenger transcript does not definitively show lack of knowledge
    and does not contain all the conversations that occurred between Mary Ann
    30
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    No. 20-50112
    Lara and Flores. The Government was arguing that because there is no
    evidence of (1) what was said between Mary Ann Lara, Melissa Lara, and
    Flores in person or on the phone, (2) what was said during the audio calls
    between Mary Ann Lara and Flores referenced in the Facebook Messenger
    transcript, or (3) what was said on WhatsApp between Mary Ann Lara and
    Flores, the jury could reasonably infer that the Facebook Messenger
    transcript was not a complete record of the sisters’ conversations with
    Flores. To further support the inference that Flores may have revealed the
    truck’s contents to the Laras in one of these conversations not in the record
    despite not having done so in the Facebook Messenger conversation, the
    Government reminded the jury that (4) Carla Lara had not revealed to
    Trinidad that the truck she would be driving would contain drugs until after
    Trinidad had asked several times and (5) the Laras stopped asking Flores
    about the contents of the truck after they met with him in person.
    Prosecutors can discuss such reasonable inferences during closing
    arguments. See Vargas, 
    580 F.3d at 278
    . Even if the prosecutor did mean to
    imply that Mary Ann Lara may have deleted some of the more incriminating
    messages, this argument would be an appropriate response to defense
    counsel’s statement that the Facebook Messenger transcript was a complete
    record of any conversations with Flores. See 
    id. at 279
    . Accordingly, the
    Government’s remarks in its rebuttal closing argument were not improper. 7
    7
    The Laras also argue that the Government’s rebuttal closing argument indirectly
    commented on their Fifth Amendment right to remain silent because only they could have
    answered the rhetorical questions that the Government asked in the first paragraph of the
    above-quoted remarks. However, as explained in supra Part II.C, the Government may ask
    rhetorical questions that are “inferential in substance” when urging “the conclusions it
    thinks the jury should draw from the evidence.” Sorzano, 
    602 F.2d at 1202
    .
    31
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    No. 20-50112
    III.
    In addition to the above issues raised by both Mary Ann Lara and
    Melissa Lara, Melissa Lara independently raises the following three issues.
    A.
    The Government called Agent Katherine Leonard to testify regarding
    alleged inconsistencies between what Priscilla Ramirez had told agents and
    what she had said on the witness stand. In her testimony at trial, Ramirez
    (1) denied knowing whether the Lara sisters had issues with the truck;
    (2) denied having concerns about what was in the truck during the trip to
    Mexico because she had asked Mary Ann Lara, prior to the trip, whether the
    truck was stolen or a drug truck; and (3) denied being nervous at the border
    checkpoint for any reason other than her daughter getting out of her car seat.
    However, Agent Leonard testified that Ramirez had previously told her
    during a debriefing that (1) the Lara sisters had told her that something was
    wrong with the truck; (2) she had tried to put distance between her vehicle
    and the truck because she had a “bad feeling” and was worried that
    something was wrong with the truck; and (3) she had felt nervous when she
    saw that Melissa Lara had pulled the truck directly behind her vehicle at the
    border checkpoint. Agent Leonard also testified that Ramirez had told her
    (4) that the Laras were following her because they did not know the way back
    to San Antonio and (5) that she had encouraged the Laras to drive faster.
    Melissa Lara argues that these portions of Agent Leonard’s testimony are
    inadmissible hearsay evidence.
    Statements that “(1) the declarant does not make while testifying at
    the current trial or hearing; and (2) a party offers in evidence to prove the
    truth of the matter asserted in the statement” are hearsay. Fed. R. Evid.
    801(c). Hearsay is generally inadmissible. See Fed. R. Evid. 802. Because
    Melissa Lara did not object to Agent Leonard’s testimony at trial, we yet
    32
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    No. 20-50112
    again review the district court’s admission of the testimony only for plain
    error. See Oti, 872 F.3d at 690. As stated above, to prevail under plain error
    review, the appellant must show that: “(1) there was an error; (2) the error
    was clear or obvious; (3) the error affected his or her substantial rights; and
    (4) the error seriously affects the fairness, integrity, or public reputation of
    judicial proceedings such that we should exercise our discretion to reverse.”
    Id.
    The Government conceded at oral argument that the district court
    clearly erred by admitting the relevant portion of Agent Leonard’s testimony
    without instructing the jury that it could not consider the evidence
    substantively. We agree. Agent Leonard’s testimony contained out-of-court
    statements made by Ramirez. Though “[e]vidence of a witness’ prior
    inconsistent statements may be admitted to impeach that witness,” United
    States v. St. Junius, 
    739 F.3d 193
    , 202 (5th Cir. 2013), the court did not
    instruct the jury that it could only consider Ramirez’s out-of-court
    statements for impeachment purposes. Without such an instruction, the
    admission of Agent Leonard’s testimony was a clear and obvious error.
    Accordingly, we proceed to the third prong of plain error review.
    “A defendant demonstrates that an error had an effect on [her]
    substantial rights when [s]he shows a reasonable probability that the jury,
    absent the error, would have acquitted [her].” Oti, 872 F.3d at 693. As
    explained above, Agent Leonard’s testimony contained five relevant hearsay
    statements. Regarding the first statement, Agent Schreiner also testified that
    Melissa Lara told him the truck was driving funny and shaking. Regarding the
    remaining four statements, the reasons why Ramirez tried to put distance
    between her vehicle and the truck, why she felt nervous at the border
    checkpoint, and why the Laras were following her are minimally relevant to
    Melissa Lara’s knowledge of methamphetamine in the truck, as is the
    question of whether Ramirez encouraged the Laras to drive faster. For these
    33
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    No. 20-50112
    reasons, Melissa Lara has not shown that the jury would have acquitted her
    but for the admission of Agent Leonard’s hearsay testimony. Accordingly,
    she cannot prevail on this issue under plain error review.
    B.
    Melissa Lara argues that the cumulative effect of the claimed trial
    errors described above resulted in the denial of her right to a fair trial. “The
    cumulative error doctrine provides that an aggregation of non-reversible
    errors (i.e., plain errors failing to necessitate reversal and harmless errors)
    can yield a denial of the constitutional right to a fair trial, which calls for
    reversal.” United States v. Delgado, 
    672 F.3d 320
    , 343-44 (5th Cir. 2012) (en
    banc) (cleaned up). We apply this doctrine “only in rare instances,” in cases
    where “errors ‘so fatally infect[ed] the trial that they violated the trial’s
    fundamental fairness.’” 
    Id. at 344
     (citation omitted). In other words, the
    cumulative error doctrine “justifies reversal only in the unusual case in which
    synergistic or repetitive error violates the defendant’s constitutional right to
    a fair trial.” 
    Id.
    This case does not present such a rare situation. Melissa Lara has
    demonstrated that errors occurred at trial—notably, the admission of Agent
    Huerta’s testimony that load drivers generally know that they’re
    transporting narcotics and the admission of Agent Leonard’s testimony
    regarding Ramirez’s out-of-court statements. However, as explained above,
    Agent Huerta’s testimony does not justify reversal under plain error review,
    and Agent Leonard’s testimony was either cumulative or minimally relevant
    to the question of whether Melissa Lara knew that the truck contained drugs.
    Because the errors were unrelated to each other, and because one of the
    errors is extremely unlikely to have influenced the jury’s verdict, we cannot
    say that this is the rare case in which individual errors do not justify reversal
    34
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    No. 20-50112
    but the synergistic combination of multiple errors violated the defendant’s
    right to a fair trial.
    C.
    Section 3B1.4 of the Sentencing Guidelines states, “If the defendant
    used or attempted to use a person less than eighteen years of age to commit
    the offense or assist in avoiding detection of, or apprehension for, the offense,
    increase by 2 levels.” Melissa Lara argues that the district court erred by
    applying this enhancement to her sentence.
    Whether a defendant “used or attempted to use a minor to assist in
    avoiding detection within the meaning of § 3B1.4 is a conclusion of law that
    we review de novo, while any findings of fact made in support of that
    determination we review for clear error.” United States v. Mata, 
    624 F.3d 170
    , 175 (5th Cir. 2010). A sentencing court’s finding of fact is clearly
    erroneous if, after reviewing all the evidence, the reviewing court “is left with
    the definite and firm conviction that a mistake has been committed.” 
    Id. at 173
     (citation omitted). “A factual finding is not clearly erroneous so long as
    it is ‘plausible in light of the record as a whole.’” 
    Id.
     (citation omitted).
    “Absent other evidence, the mere presence of a minor at the scene of
    a crime is insufficient to support the application of § 3B1.4.” Mata, 
    624 F.3d at 176
     (5th Cir. 2010) (cleaned up). Rather, “the defendant must take some
    affirmative action to involve the minor in the offense.” 
    Id.
     However, “[w]hen
    a defendant’s crime is previously planned—when, for example, she leaves
    the house knowing she is on her way to smuggle drugs . . . —the act of
    bringing the child along instead of leaving the child behind is an affirmative
    act that involves the minor in the offense,” at least in cases “where additional
    circumstantial evidence tends to confirm that the defendant brought the
    minor along as a decoy and to avoid detection.” 
    Id. at 176-77
    . Accordingly,
    “a defendant who makes a decision to bring a minor along during the
    35
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    No. 20-50112
    commission of a previously planned crime as a diversionary tactic or in an
    effort to reduce suspicion is subject to having her sentence enhanced under
    § 3B1.4.” Id. at 175.
    When Melissa Lara was apprehended at the border driving a truck
    containing methamphetamine, a child was in the car. At sentencing, the
    district court rejected Melissa Lara’s argument that she had brought the child
    with her to Mexico so that the child could visit his father, finding instead that
    Melissa Lara had used the child as “a cover story.” A variety of evidence
    supported this finding: the child had been sitting in the backseat,
    unrestrained by a car seat or seat belt; Flores had told Mary Ann Lara to tell
    border agents that she and Melissa Lara had come to Mexico so that the child
    could see his dad; the government had stated at sentencing that Melissa Lara
    and Mary Ann Lara told border agents that they had taken the child to
    Mexico to see his father, and neither Lara objected to this statement; and
    Agent Huerta had testified that drug traffickers commonly “bring kids to
    distract the [Customs and Border Protection] officer.” Because the district
    court’s finding is plausible based on this record, its finding is not clearly
    erroneous. Additionally, because Mary Ann Lara and Flores planned the
    truck’s crossing the previous day, the district court could have reasonably
    inferred that Melissa Lara’s crime was previously planned. See United States
    v. Caldwell, 
    448 F.3d 287
    , 292 (5th Cir. 2006) (explaining that a “sentencing
    court is permitted to make common-sense inferences from the circumstantial
    evidence”).
    By thus using a child as a diversionary tactic during the commission of
    a previously planned crime, Melissa Lara committed an affirmative act that
    involved the child in drug trafficking. Accordingly, the district court did not
    err by applying the § 3B1.4 enhancement to Melissa Lara’s sentence. See
    Mata, 
    624 F.3d at 175
    .
    36
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    No. 20-50112
    IV.
    Mary Ann Lara was sentenced to 288 months in prison, a downward
    variance from her guidelines range of 360 months to life imprisonment. She
    argues that her prison sentence was substantively unreasonable. Specifically,
    she contends that because the methamphetamine Guideline has evolved
    through congressional mandates rather than through the Sentencing
    Commission’s examination of empirical data, national expertise, and expert
    opinion, the Guideline lacks an empirical basis, results in guidelines ranges
    that are greater than necessary to determine the appropriate sentence, and
    produces overly severe sentences.
    “We presume sentences within or below the calculated guidelines
    range are reasonable.” United States v. Simpson, 
    796 F.3d 548
    , 557 (5th Cir.
    2015). Mary Ann Lara relies on Kimbrough v. United States, in which the
    Supreme Court held that a district court did not abuse its discretion by
    concluding that the disparity between guidelines ranges for crack and powder
    cocaine offenses resulted in an excessive sentence, given that the crack
    cocaine Guideline did not reflect the Sentencing Commission’s ordinary
    methods of relying on empirical evidence and national experience. 
    552 U.S. 85
    , 109-10 (2007). However, we have held that Kimbrough does not disturb
    the reasonableness presumption, even if the relevant Guideline is not
    empirically based. For example, in United States v. Mondragon-Santiago, we
    rejected the argument that the unlawful entry Guideline “is not empirically-
    based, and therefore should not be afforded the appellate presumption of
    reasonableness,” explaining that while Kimbrough allows “district courts, in
    their discretion, to consider the policy decisions behind the Guidelines,
    including the presence or absence of empirical data, as part of their § 3553(a)
    analyses,” the decision “does not require discarding the presumption [of
    reasonableness]    for   sentences   based      on   non-empirically-grounded
    Guidelines.” 
    564 F.3d 357
    , 366 (5th Cir. 2009). Similarly, in United States v.
    37
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    No. 20-50112
    Duarte, another case involving the unlawful entry Guideline, we held that
    “Kimbrough does not force district or appellate courts into a piece-by-piece
    analysis of the empirical grounding behind each part of the sentencing
    guidelines.” 
    569 F.3d 528
    , 530 (5th Cir. 2009). Rather, “the thrust of recent
    Supreme Court decisions has been to affirm the traditional entrustment of
    sentencing to the discretion of district courts, close to the ground and more
    cognizant of the details of offender and offense that should be determinative
    of sentence.” 
    Id. at 530-31
    .
    Both Mondragon-Santiago and Duarte involved the unlawful entry
    Guideline. However, no part of the reasoning of Mondragon-Santiago and
    Duarte was specific to that Guideline. Indeed, as Mary Ann Lara
    acknowledges, we have concluded in unpublished opinions that these
    decisions also control challenges to the substantive reasonableness of the
    methamphetamine Guideline. See, e.g., United States v. Labrador, 734 F.
    App’x 270, 271 (5th Cir. 2018) (unpublished) (concluding that Mondragon-
    Santiago “foreclose[s]” the argument that a “within-guidelines sentence is
    substantively unreasonable because the methamphetamine Guideline is not
    based on empirical evidence” (citing 
    564 F.3d at 366-67
    )); United States v.
    Croxton, 693 F. App’x 327, 328 (5th Cir. 2017) (unpublished) (“Croxton’s
    contention that the district court should have taken into account the
    empirical basis for the methamphetamine Guideline is foreclosed.” (citing
    Duarte, 
    569 F.3d at 530-31
    )). Accordingly, we hold that Mondragon-Santiago
    and Duarte foreclose Mary Ann Lara’s argument that because the
    methamphetamine Guideline is not empirically-based, her below-guidelines
    sentence was substantively unreasonable.
    V.
    For the foregoing reasons, we AFFIRM the judgment of the district
    court.
    38