In Re HU ( 2021 )


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  • Case: 19-2104    Document: 34      Page: 1    Filed: 03/17/2021
    NOTE: This disposition is nonprecedential.
    United States Court of Appeals
    for the Federal Circuit
    ______________________
    IN RE: HUPING HU, MAOXIN WU,
    Appellants
    ______________________
    2019-2104, 2019-2105, 2019-2106, 2019-2107
    ______________________
    Appeals from the United States Patent and Trademark
    Office, Patent Trial and Appeal Board in Nos. 11/670,996,
    11/944,631, 13/449,739, 13/492,830.
    ______________________
    Decided: March 17, 2021
    ______________________
    HUPING HU, MAOXIN WU, Stony Brook, NY, pro se.
    MICHAEL S. FORMAN, Office of the Solicitor, United
    States Patent and Trademark Office, Alexandria, VA, for
    appellee Andrew Hirshfeld. Also represented by THOMAS
    W. KRAUSE, FARHEENA YASMEEN RASHEED.
    ______________________
    Before NEWMAN, LOURIE, and STOLL, Circuit Judges.
    NEWMAN, Circuit Judge.
    Huping Hu and Maoxin Wu (collectively, “Hu” or “ap-
    plicants”) appeal four decisions of the U.S. Patent Trial and
    Case: 19-2104    Document: 34     Page: 2   Filed: 03/17/2021
    2                                                 IN RE: HU
    Appeal Board (“PTAB” or “Board”), 1 affirming the final re-
    jections of claims based on subject matter described as
    “quantum entanglement.” Hu defines quantum entangle-
    ment as the entanglement of “quantum spins of photons,
    electrons and nuclei.”      U.S. Patent Application No.
    11/944,631 (“the ’631 application”), ¶ 3.
    Hu states that “quantum spins of photons, electrons
    and nuclei have now been successfully entangled in various
    ways for purposes of quantum computation and communi-
    cation.” Id. In the four patent applications on appeal,
    quantum entanglement is said to occur when fundamental
    particles such as photons or electrons interact and become
    linked; whereby when the particles are moved apart and
    separated by distance, the molecules’ mechanical states
    (such as their spin, momentum, and polarization) remain
    coupled, and if the state of one entangled particle is
    changed, its distant linked particle is instantaneously af-
    fected.
    The U.S. Patent and Trademark Office (“PTO”) sum-
    marizes the concept of quantum entanglement as the abil-
    ity “to change the characteristics of one substance via the
    manipulation of a completely physically separate sub-
    stance.” PTO Br. at 4. Hu states that the inventors “have
    harnessed and developed quantum entanglement and non-
    local effects into useful technologies to serve the mankind
    1    Ex Parte Hu, No. 2018-007211, 
    2019 WL 2285560
    (P.T.A.B. May 16, 2019) (“the ’631 Application); Ex Parte
    Hu, No. 2018-003120, 
    2019 WL 2255472
     (P.T.A.B. May 16,
    2019) (“the ’996 Application); Ex Parte Hu and Wu, No.
    2018-003401, 
    2019 WL 2255476
     (P.T.A.B. May 16, 2019)
    (“the ’830 Application); Ex Parte Hu, No. 2018-003398,
    
    2019 WL 2255475
     (P.T.A.B. May 16, 2019) (“the ’739 Ap-
    plication). The four Board opinions are substantially iden-
    tical in analysis.
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    IN RE: HU                                                    3
    in many areas, such as communication, engineering,
    health, medicine and recreation.” Hu Br. at 5.
    The four patent applications at issue are directed to
    various methods or apparatus for producing or using quan-
    tum entanglement. The patent applications are as follows:
    U.S. Patent Application No. 11/944,631, filed
    Nov. 25, 2007 (“the ’631 application”)
    The ’631 application is titled “Method and Apparatus
    for Producing Non-Local Physical, Chemical and Biological
    Effects.” The application states that it concerns the
    “method of producing . . . effects on physical, chemical
    and/or biological systems through quantum entanglement
    mediated processes, to apparatus for such productions, and
    to method of using the non-local effects for beneficial pur-
    poses.” ’631 application at ¶ 2. The ’631 application states
    that: “One benefit of the present invention is that the phys-
    ical and/or chemical properties such as pH values, temper-
    atures and gravities of two or more quantum-entangled
    systems separated by arbitrary distances can be, in one
    broad embodiment, manipulated or modified for a desired
    purpose.” Id. at ¶ 23.
    The ’631 application describes the method whereby, as
    a first step, a “certain volume of a liquid, gel, gas, solid or
    a composition thereof such as water” is quantum entangled
    by being “simply left alone at a desired temperature for a
    certain period of time before use.” Id. at ¶ 46. This mate-
    rial is then divided into the target substance in a container
    at location A, and an originating substance in another con-
    tainer at location B. Id. at ¶¶ 47–49. The originating sub-
    stance is then manipulated, and the effects are manifested
    in the target substance through quantum entanglement.
    Id. at ¶ 49. Claim 1 is deemed representative:
    1. A method of producing a non-local effect in
    a target substance through manipulating an
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    4                                                  IN RE: HU
    originating substance and detecting said nonlocal
    effect which comprises the steps of:
    selecting a substance which comprises said tar-
    get substance and said originating substance;
    generating a plurality of quantum entangle-
    ments within a plurality of quantum entities in
    said substance by irradiating said substance with
    magnetic pulse, laser light or microwave, or letting
    said substance sit for at least thirty days;
    separating said substance into said target sub-
    stance and said originating substance;
    positioning said target substance at a first lo-
    cation in a first stable environment and said origi-
    nating substance at a second location in a second
    stable environment;
    cooling, heating or adding a third substance to
    said originating substance; and
    detecting with a high-precision instrument a
    change in weight, temperature and/or pH value of
    said target substance;
    whereby said non-local effect is produced
    through a non-local process mediated by said quan-
    tum entanglements and said non-local effect is said
    change in weight, temperature and/or pH value of
    said target substance.
    J.A. 79. The ’631 specification provides an example
    whereby the container with the originating substance is
    chilled by placement in liquid nitrogen, and the pH of the
    target substance in a container in another room is altered,
    due to quantum entanglement. ’631 Application at ¶ 49.
    The examiner rejected all of the ’631 claims on appeal,
    viz. claims 1, 7, 9, 10, 16, 18, 19, 25, 27, and 70–81, on
    grounds of 
    35 U.S.C. § 101
     as inoperative, and 
    35 U.S.C. § 112
     as not enabled. The examiner stated to the Board:
    Appellant’s disclosure and claimed invention that
    the weight, temperature and/or chemical
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    IN RE: HU                                                    5
    properties (pH value) of an isolated target sub-
    stance (e.g. water) can be changed by manipulating
    a separate “originating substance” (e.g. water) that
    is physically separated and isolated from the “tar-
    get substance” is not credible and consequently
    fails the “useful invention” (utility) requirement of
    35 U.S.C. 101 . . . Appellant’s experiments and ex-
    perimental data at paragraphs 83–99 of the writ-
    ten description fails to adequately disclose and
    describe the claimed subject matter in such a way
    as to enable one of ordinary skill in the art to prac-
    tice the invention as claimed without undue exper-
    imentation. Moreover, the invention as claimed
    and described is incapable of functioning as
    claimed as set forth above; accordingly, the appli-
    cation fails to meet the enablement requirement.
    ’631 Application, Examiner’s Answer at 2, 5. The Board
    affirmed, and Hu appeals, stating that the Board erred in
    law and fact.
    U.S. Patent Application No. 13/449,739, filed
    April 18, 2012 (“the ’739 application”)
    The ’739 application is titled “Method and Apparatus
    for Producing Quantum Entanglement and Non-Local Ef-
    fects of Substances,” and is particularly directed to anes-
    thetic and other medication effects. The specification
    describes the benefits of the claimed method:
    One benefit of the present invention is that a sub-
    stance such as a medication can be repeatedly used
    to obtain a beneficial effect on a biological system
    without the said biological system physically con-
    suming the said substance. A second benefit of the
    present invention is that the beneficial effect of a
    substance such as a medication can be, in one broad
    embodiment, delivered to a biological system such
    as a patient from a remote location of arbitrary dis-
    tance. A third benefit of the present invention is
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    6                                                   IN RE: HU
    that two parts of a quantum-entangled medium
    with one part being physically at one location and
    a second part being physically at another location
    of arbitrary distance can be, in one broad embodi-
    ment, used to transmit an encoded message.
    ’739 application at ¶ 24. The ’739 application presents the
    example of administration of a general anesthetic by “ap-
    plying magnetic pulses to a biological system such as the
    human brain when a substance such as a general anes-
    thetic was placed in between caused the brain to feel the
    effect of said anesthetic for several hours after the treat-
    ment as if the test subject had actually inhaled the same.”
    Id. at ¶ 9. Figure 1A is presented as illustrative of admin-
    istration of an anesthetic:
    Fig 1A
    The anesthetic is placed in a container outside the patient’s
    head, and the container is attached to a magnetic coil con-
    nected to an audio system such as a radio. ’739 application
    at ¶¶ 42–43. The Board described the method as “directing
    music toward that brain through a container of that anes-
    thetic.” ’739 Application, Board Op. at *3. Claim 1 is
    deemed representative:
    1. An apparatus for producing a plurality of
    quantum entanglements between a first plurality
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    IN RE: HU                                                   7
    of quantum entities in a chemical substance and a
    second plurality of quantum entities in a human or
    animal, a non-local chemical effect of said human
    or animal on said chemical substance through said
    plurality of quantum entanglements and/or a non-
    local biological effect of said chemical substance on
    said human or animal through said plurality of
    quantum entanglements which comprises:
    a quantum-entanglement generating source
    which emits a plurality of quantum-entangling
    photons or magnetic pulses when said source oper-
    ates;
    a first container for holding said chemical sub-
    stance disposed next to said source; and
    said chemical substance in said container;
    such that when said first container is filled
    with said chemical substance is disposed next to
    said human or animal, and said source operates,
    said photons or magnetic pulses interact with said
    first plurality of quantum entities in said chemical
    substance and said second plurality of quantum en-
    tities in said human or animal generating said plu-
    rality of quantum entanglements, said non-local
    chemical effect through said plurality of quantum
    entanglements which comprises an effect of said
    human or animal on a chemical property or process
    of said chemical substance and/or said biological
    non-local effect through said plurality of quantum
    entanglements which comprises an effect of said
    chemical substance on a biological property or pro-
    cess of said human or animal.
    J.A. 1990.
    The Board affirmed the rejection of all of the claims of
    the ’739 application, i.e., claims 1–3, 6–8, 12, and 13 under
    
    35 U.S.C. § 112
     on grounds of written description, indefi-
    niteness, and lack of enablement. Reviewing the applica-
    tion, the Board stated:
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    8                                                      IN RE: HU
    [D]ue to the absence of any known scientific princi-
    ples explaining how Appellant’s invention could
    possibly operate in this manner, the absence of any
    cogent explanation in Appellant’s Specification re-
    garding the general principals or mechanisms
    causing this to occur, and the absence of any verifi-
    able test data reasonably attributable to the pur-
    ported     result,    the    Examiner     reasonably
    characterized Appellant’s Specification as failing to
    satisfy the enablement requirement. . . . We find
    no explanation as to why ordinary and conven-
    tional audio produces any meaningful quantum en-
    tanglements and, even if it did, why they would
    have any meaningful effects on the pharmacologi-
    cal interaction between an anesthetic agent and
    the brain. . . . We are also not apprised of any data
    logically evincing such a pharmacological interac-
    tion has actually occurred.
    ’739 Application, Board Op. at *3 (footnote omitted).
    The Board also affirmed the rejection under § 101, stat-
    ing:
    The Examiner concludes claim 1 is directed to a
    natural phenomenon of generating quantum en-
    tanglements which, along with their interactions
    with a subject, are natural results of magnetic
    pulses or photons, and therefore falls within a judi-
    cial exception to subject matter eligible for patent-
    ing. . . . The Examiner considers the source and
    container limitations and determines they lack the
    particularity necessary for a machine, transfor-
    mation, or useful application to bring the claim
    within the ambit of subject matter that is a patent-
    eligible practical application. . . . The Examiner’s
    analysis, summarized above, is consistent with
    PTO guidance and stands essentially uncontro-
    verted. Accordingly, we adopt the Examiner's
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    IN RE: HU                                                    9
    position and sustain the § 101 rejection on the basis
    set forth by the Examiner.
    Id. at *7, *9 (footnote omitted).
    U.S. Patent Application No. 13/492,830, filed
    June 9, 2012) (“the ’830 application”)
    The ’830 application is titled “Method and Apparatus
    for Producing and Detecting Non-Local Effects of Sub-
    stances,” and, like the other applications, recites the
    “method for communicating between two remote locations
    through two parts of a quantum-entangled medium with
    one part being applied to a responsive target such as a par-
    ticular biological, chemical or other system at one location
    and a second part being subsequently entangled with a
    particular substance representing a particular message
    through quantum-entangling members such as photons at
    a remote location of arbitrary distance.” ’830 application
    at ¶ 25. The ’830 application describes non-local effects of
    medications, and presents the example where the physio-
    logical effects of the drug Primatene, a medication that in-
    cludes a heart stimulant, are experienced by a remotely
    located person who did not consume the drug, based on mi-
    crowave activated quantum entanglement. The specifica-
    tion provides the example where a solution of Primatene,
    containing the heart stimulant ephedrine, is exposed to mi-
    crowave radiation in one room, and effects are felt by a per-
    son in a room about 50 feet away “in the form of rapidly
    increased heart rate for at least four (4) minutes in the
    range of 1-6 points (beats) or l.5%-10% above the fluctuat-
    ing ranges of the baselines.” Id. at ¶¶ 102–103, 120. Claim
    5 is deemed representative:
    5. A method of producing and detecting a sec-
    ond plurality of quantum entanglements between
    a third plurality of quantum entities in a first tar-
    get and a fourth plurality of quantum entities in a
    second target, a first non-local effect of said second
    target on said first target through said second
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    10                                                     IN RE: HU
    plurality of quantum entanglements and/or a sec-
    ond nonlocal effect of said first target on said sec-
    ond target through said second plurality of
    quantum entanglements which comprises the steps
    of:
    selecting said first target which comprises a
    first chemical substance, human or animal at a
    first location;
    selecting said second target which comprises a
    second chemical substance, human or animal at a
    second location;
    providing a first water-based medium at said
    first location and a second water-based medium at
    said second location, a first plurality of quantum
    entities in said first medium being in a first plural-
    ity of quantum entanglements with a second plu-
    rality of quantum entities in said second medium;
    providing a detecting means for detecting said
    second plurality of quantum entanglements, said
    first non-local effect and/or said second non-local ef-
    fect when said detecting means operates;
    causing said first target to interact with said
    first water-based medium through a first contact or
    radiation from a first photon or magnetic pulse
    generating source;
    causing said second target to interact with said
    second water-based medium through a second con-
    tact or radiation from a second photon or magnetic
    pulse generating source; and
    detecting said second plurality of quantum en-
    tanglements, said first non-local effect and/or said
    second non-local effect;
    whereby said second plurality of quantum en-
    tanglements between said third plurality of quan-
    tum entities in said first target and said fourth
    plurality of quantum entities in said second target
    is generated through said interaction between said
    third plurality of quantum entities in said first
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    IN RE: HU                                                     11
    target and said first plurality of quantum entities
    in said first water-based medium and said interac-
    tion between said fourth plurality of quantum en-
    tities in said second target and said second
    plurality of quantum entities in said second water-
    based medium, and detected through said detect-
    ing means; and said first non-local effect of said sec-
    ond target on said first target, comprising a first
    effect of said second target on a first physical,
    chemical or biological property or process of said
    first target, and/or said second non-local effect of
    said first target on said second target, comprising
    a second effect of said first target on a second phys-
    ical, chemical or biological property or process of
    said second target, are generated through said sec-
    ond plurality of quantum entanglements between
    said third plurality of quantum entities in said first
    target and said fourth plurality of quantum enti-
    ties in said second target and detected through said
    detecting means.
    J.A. 4391–93.
    The PTAB held claims 5, 7–9, 11, and 12, all of the
    claims on appeal of the ’830 application, unpatentable un-
    der. § 101 as inoperative and under § 112 as not in compli-
    ance with the written description requirement and not
    enabled. The Board stated:
    We agree with the Examiner’s analysis, which
    raised reasonable doubts as to operability of Appel-
    lants’ invention and the Specification’s compliance
    with the enablement requirement. . . . The Specifi-
    cation provides a few examples of suitable sources
    and one example of a detecting method. However,
    claim 5 encompasses subject matter wherein any-
    thing capable of generating photons or magnetic
    pulses for causing quantum entanglements,
    whether known or unknown, described in
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    12                                                    IN RE: HU
    Appellants’ Specification or not, can be the
    source. . . . Even if we were to set aside the ques-
    tion of operability and assume that Appellants
    have demonstrated possession of a limited number
    of sources and at least one detecting technique, the
    scope of the right to exclude that would be granted
    by claim 5 would far exceed Appellants’ contribu-
    tion to the art—preempting the future before it has
    arrived . . . .
    ’830 Application, Board Op. at *4, *8. The Board adopted
    the Examiner’s reasoning, and rejected the claims.
    U.S. Patent Application No. 11/670,996, filed
    February 4, 2007 (“the ’996 application”)
    The ’996 application is titled “Method and Apparatus
    for Producing Quantum Entanglement and Non-Local Ef-
    fects of Substances” and describes remote effects and pro-
    ducing quantum entanglements with laser light, reciting
    the following experiment:
    [L]aser light from the laser first passed through the
    large glassware filled with 200 ml tap water and
    then through the small glassware filled with a sub-
    stance . . . located about 300 cm away. . . . After 30
    min exposure to the laser light, a test subject con-
    sumed the treated tap water without being told the
    details of the experiments and report the biological
    and/or chemical effects felt for the next several
    hours.
    ’996 application at ¶ 79. Claim 1 is deemed representative:
    1. A method of producing a plurality of quan-
    tum entanglements between a first plurality of
    quantum entities in a first target and a second plu-
    rality of quantum entities in a second target, a first
    non-local effect of said second target on said first
    target through said plurality of quantum entangle-
    ments and/or a second non-local effect of said first
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    IN RE: HU                                                      13
    target on said second target through said plurality
    of quantum entanglements which comprises the
    steps of:
    selecting said first target ,which comprises a
    first chemical substance, water-based medium, hu-
    man or animal;
    selecting said second target which comprises a
    second chemical substance, water-based medium,
    human or animal;
    providing a photon or magnetic pulse generat-
    ing source, which emits a plurality of photons or
    magnetic pulses as quantum entanglement gener-
    ating members when said source operates;
    disposing said first target between said source
    and said second target or said second target be-
    tween said source and said first target; and
    driving said source to emit said photons or
    magnetic pulses which interact with said first plu-
    rality of quantum entities in said first target and
    said second plurality of quantum entities in said
    second target;
    whereby said plurality of quantum entangle-
    ments between said first plurality of quantum en-
    tities in said first target and said second plurality
    of quantum entities in said second target is gener-
    ated through said interactions of said photons or
    magnetic pulses as said quantum entanglement
    generating members with said first plurality of
    quantum entities in said first target and said sec-
    ond plurality of quantum entities in said second
    target; and said first non-local effect of said second
    target on said first target, comprising a first non-
    local effect of said second target on a first physical,
    chemical or biological property or process of said
    first target, and/or said second non-local effect of
    said first target on said second target, comprising
    a second non-local effect of said first target on a sec-
    ond physical, chemical or biological property or
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    14                                                   IN RE: HU
    process of said second target, are generated
    through said plurality of quantum entanglements.
    J.A. 5166–67. The Board held claims 1, 3–7, 11, 14, 18, 19,
    23, 24, 32–34, 36, 37, 44 and 46 of the ’996 application (all
    of the claims on appeal) unpatentable under § 101 as inop-
    erative and § 112 as not enabled. The Board held that the
    described remote effects attributed to quantum entangle-
    ment were not substantiated by adequate evidence to meet
    the requirements of patentability. The Board also ex-
    pressed skepticism as to the scientific premise of quantum
    entanglement.
    DISCUSSION
    The Board considered each application separately, and
    issued separate opinions. The applications were not all in
    the same art unit, and were processed by two examiners.
    We consolidated the four appeals for briefing and argu-
    ment.
    Hu argues that the examiners and the Board erred in
    examination procedure, for the burden of establishing un-
    patentability is on the PTO, and requires evidence based
    on prior art, knowledge, and analytic reasoning. Hu states
    that this burden is not met by skepticism and ignorance.
    Hu points to the absence of prior art, the absence of con-
    trary knowledge, and the absence of contrary evidence.
    Hu is correct that the burden is on the PTO to establish
    that the standards of patentability are not met. See 
    35 U.S.C. § 102
     (“A person shall be entitled to a patent un-
    less . . . .”). In implementation of the patent statute, on ex-
    amination the PTO bears the initial burden of presenting
    a prima facie case of unpatentability. If that burden is not
    met, patentability is established. If it is met, the burden
    shifts to the applicant, to come forward with evidence and
    argument to rebut the prima facie case. In re Piasecki, 
    745 F.2d 1468
    , 1472 (Fed. Cir. 1984). In the back-and-forth of
    argument and explanation that characterizes patent
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    IN RE: HU                                                 15
    examination, the ultimate burden of showing unpatenta-
    bility is on the PTO, as the statute requires. In re Duvi,
    
    185 F.3d 885
     (Fed. Cir. 1999) (“[T]he ultimate burden of
    establishing unpatentability is with the PTO.”); see also In
    re Oetiker, 
    977 F.2d 1443
    , 1449 (Fed. Cir. 1992) (Plager, J.,
    concurring) (“An applicant for a patent is entitled to the
    patent unless the application fails to meet the require-
    ments established by law. . . . The burden is on the Com-
    missioner to establish that the applicant is not entitled
    under the law to a patent. . . . [W]hen obviousness is at is-
    sue, the examiner has the burden of persuasion and there-
    fore the initial burden of production. Satisfying the burden
    of production, and thus initially the burden of persuasion,
    constitutes the so-called prima facie showing. Once that
    burden is met, the applicant has the burden of production
    to demonstrate that the examiner’s preliminary determi-
    nation is not correct. The examiner, and if later involved,
    the Board, retain the ultimate burden of persuasion on the
    issue. . . . Thus on appeal to this court as in the PTO, the
    applicant does not bear the ultimate burden of persuasion
    on the issue.”).
    In three of the four applications no references were
    cited; in the ’739 application the examiner rejected claims
    1, 6, and 12 under § 102(b) as anticipated by a reference of
    Kiontke. In all four applications the examiners and the
    Board stated their reasons for doubting the efficacy of the
    claimed subject matter. An examiner summarized that the
    experimental report of changing the temperature or pH of
    one substance by manipulating a physically separate and
    distant second substance “violates the first law of thermo-
    dynamics,” is “contrary to traditional understanding of
    chemistry,” and “violates the classical laws of physics.”
    ’631 Application, Examiner’s Answer at 3–4, 9. The exam-
    iner stated that the scientific principle of conservation of
    mass was violated by the asserted change of weight inside
    a closed container:
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    16                                                   IN RE: HU
    Here appellant asserts that the weight of the iso-
    lated target substance in a closed container
    changes over time even though no more water is
    added or subtracted. With the force of gravity from
    earth a constant for a particular location, appel-
    lant’s assertion that the weight of the target sub-
    stance changes while at the same location without
    the addition or subtraction of water (or other mat-
    ter) violates the established scientific principle of
    conservation of mass. Accordingly, appellant’s as-
    sertions and claims regarding a change in weight
    of the target substance are not credible and the
    claimed invention lacks utility.
    ’631 Application, Examiner’s Answer at 3. The examiner
    further stated that the enablement requirement was not
    met:
    Appellant’s experiments and experimental data at
    paragraphs 83–99 of the written description fails to
    adequately disclose and describe the claimed sub-
    ject matter in such a way as to enable one of ordi-
    nary skill in the art to practice the invention as
    claimed without undue experimentation. Moreo-
    ver, the invention as claimed and described is inca-
    pable of functioning as claimed as set forth above;
    accordingly, the application fails to meet the ena-
    blement requirement.
    Id. at 5. Hu responded that the examiner had no evidence
    or other support for these arguments, which are mere spec-
    ulation and without foundation, and thus contrary to the
    rules of patentability, as well as not conforming to the re-
    quirements of patent examination and the placement of the
    burden of proof.
    The Board sustained the rejection, stating that “the Ex-
    aminer reasonably characterized Appellant’s invention as
    being of an incredible nature.” ’631 Application, Board Op.
    at *4. Precedent supports such an examination rejection,
    Case: 19-2104    Document: 34      Page: 17     Filed: 03/17/2021
    IN RE: HU                                                   17
    in an appropriate case. See In re Cortright, 
    165 F.3d 1353
    ,
    1357 (Fed. Cir. 1999) (“The PTO may establish a reason to
    doubt an invention’s asserted utility when the written de-
    scription ‘suggest[s] an inherently unbelievable undertak-
    ing or involve[s] implausible scientific principles.’” (quoting
    In re Brana, 
    51 F.3d 1560
    , 1566 (Fed. Cir. 1995)) (altera-
    tions in original)).
    The Board stated its skepticism of the claimed inven-
    tion’s operability, citing the absence of support in scientific
    principle and credible data:
    We have no doubt that if Appellant’s invention is
    able to use quantum entanglement to alter the
    weight, temperature and/or pH value of a first sub-
    stance by modifying only some other second sub-
    stance that had previously been exposed to
    “magnetic pulses, laser light, or microwave,” with
    the first substance it would be both groundbreak-
    ing and revolutionary . . . However, due to the ab-
    sence of any known scientific principles explaining
    how Appellant’s invention could possibly operate in
    this manner, the absence of any cogent explanation
    in Appellant’s Specification regarding the general
    principals [sic] or mechanisms causing this to oc-
    cur, and the absence of any verifiable test data rea-
    sonably attributable to the purported result, the
    Examiner reasonably characterized Appellant’s in-
    vention as being of an incredible nature.
    ’631 Application, Board Op. at *4 (emphasis in original)
    (footnote omitted). We agree that the Board reasonably
    placed weight on the absence of scientific explanation of the
    announced effects of magnetic pulse, laser light, or micro-
    wave radiation, and “why spin or any other quantum prop-
    erty of entangled particles would bring about these types
    of changes in a remote, ‘non-local’ portion of a sample or
    substance.” 
    Id.
     The Board concluded:
    Case: 19-2104     Document: 34      Page: 18    Filed: 03/17/2021
    18                                                    IN RE: HU
    The Examiner provided a detailed analysis, citing
    various evidentiary sources, including, but not lim-
    ited to, those submitted by Appellant, in consider-
    ing the question of enablement, and the question of
    whether the claimed invention contravenes estab-
    lished scientific principles, as that question relates
    to the utility requirement. . . . We agree with the
    Examiner’s analysis, which raised reasonable
    doubts as to operability of Appellant’s invention
    and the Specification’s compliance with the enable-
    ment requirement.
    Id. at *3.
    Hu argues on appeal that no authority supports the
    Board’s theory that the claimed inventions are contrary to
    scientific principles and that the Board cited no authority
    for its conclusion. Hu provided twenty-five scientific pub-
    lications by physicists concerning quantum entanglement,
    and five publications authored by Huping Hu and Maoxin
    Wu concerning observations such as those set forth in their
    patent applications. Hu states that the examiners and the
    Board “resort[ed] to speculation, unfounded assumptions
    or hindsight reconstruction.” Hu Br. at 54 (quoting In re
    Warner, 
    379 F. 2d 1011
    , 1017 (C.C.P.A. 1967)). Hu states
    that physicists knowledgeable in the science of quantum
    mechanics would understand the principles of quantum en-
    tanglement, although the PTO examiners and the Board
    did not.
    An examiner informed the Board that “the concept of
    quantum entanglement per se is not being disputed.” ’996
    Application, Examiner’s Answer at 7. An examiner ob-
    served that “[q]uantum entanglement has been observed
    momentarily in highly controlled experiments involving
    photons, electrons and more recently macroscopically in di-
    amonds . . . conducted under extreme conditions that last
    for fractions of a second.” ’631 Application, Examiner’s An-
    swer at 11, 16. The examiners’ rejections were based on
    Case: 19-2104    Document: 34      Page: 19     Filed: 03/17/2021
    IN RE: HU                                                   19
    skepticism concerning Hu’s application of quantum entan-
    glement to produce the effects Hu described and claimed.
    The Board found that the scientific articles cited by Hu
    did not provide a scientific basis for Hu’s reports of physical
    or chemical or biological behavior attributed to quantum
    entanglement. We agree that this finding comports with
    the cited scientific articles.
    The Board did not err in requiring Hu to establish the
    operability of his asserted discoveries, in view of the con-
    flict with ordinary experience as well as with established
    scientific principles. See Process Control Corp. v. HydRe-
    claim Corp., 
    190 F.3d 1350
    , 1359 (Fed. Cir. 1999) (holding
    claims inoperable because they violate the principle of con-
    servation of mass); Newman v. Quigg, 
    877 F.2d 1575
     (Fed.
    Cir. 1989) (describing device as an operating perpetual mo-
    tion machine violates the first or second law of thermody-
    namics); In re Swartz, 50 F. Appx 422, 424–25 (Fed. Cir.
    2002) (claims to process said to implement “cold fusion” re-
    jected as directed to an “unattainable result”). In Swartz
    the Board found that “results in the area of ‘cold fusion’
    were irreproducible as of the filing date of this application,
    and that those skilled in this art would ‘reasonably doubt’
    the asserted utility and operability of cold fusion.” Id. at
    424.
    The PTO, as the nation’s guardian of technologic inven-
    tion, must be receptive to unusual concepts, for the core of
    invention is unobviousness. However, concepts that strain
    scientific principles are properly held to a heightened
    standard, typically measured by reproducibility of results.
    Here the Board was presented with an apparent departure
    from conventional scientific understanding, and the Board
    appropriately sustained the examiners’ requirements for
    experimental verification. The Board applied a reasonable
    and objective standard, and acted reasonably in sustaining
    the examiners’ requirements. Should further investigation
    Case: 19-2104    Document: 34      Page: 20    Filed: 03/17/2021
    20                                                   IN RE: HU
    bring peer recognition and verifiable results, the PTO and
    the scientific community would surely be interested. 2
    We affirm the Board’s holding, as to all four patent ap-
    plications, that there is not scientific support for the
    claimed methods or apparatus, and that the experimental
    data and explanations are inadequate to support the novel
    results and scientific principles asserted by Hu. “When a
    claim requires a means for accomplishing an unattainable
    result, the claimed invention must be considered inopera-
    tive as claimed and the claim must be held invalid under
    either § 101 or § 112 of 35 U.S.C.” Raytheon Co. v. Roper
    Corp., 
    724 F.2d 951
    , 956 (Fed. Cir. 1983); see also In re Mil-
    ligan, 
    101 F.3d 715
     (Fed. Cir. 1996) (“[A]s we conclude as a
    matter of law that those of reasonable skill in the art would
    not find Milligan’s contentions of utility credible, we must
    affirm [on the ground] of the lack of utility . . . .”).
    CONCLUSION
    The Board’s decisions in the four applications on ap-
    peal are affirmed, rejecting all of the claims on appeal.
    AFFIRMED
    COSTS
    No costs.
    There are more things in heaven and earth, Horatio,
    2
    Than are dreamt of in your philosophy.
    W. Shakespeare, HAMLET, Act 1, Scene 5, ll. 166–67.