Bristol-Myers Squibb Co. v. Superior Court of San Francisco County ( 2016 )


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  • Filed 8/29/16
    IN THE SUPREME COURT OF CALIFORNIA
    BRISTOL-MYERS SQUIBB COMPANY, )
    )
    Petitioner,               )
    )                             S221038
    v.                        )
    )                       Ct.App. 1/2 A140035
    THE SUPERIOR COURT                   )
    OF SAN FRANCISCO COUNTY,             )
    )                      San Francisco County
    Respondent;               )                    Super. Ct. JCCP No. 4748
    )
    BRACY ANDERSON et al.,               )
    )
    Real Parties in Interest. )
    ____________________________________)
    Bristol-Myers Squibb Company (BMS), a pharmaceutical manufacturer,
    conducts significant business and research activities in California but is neither
    incorporated nor headquartered here. In March 2012, eight separate amended
    complaints were filed in San Francisco Superior Court by or on behalf of 678
    individuals, consisting of 86 California residents and 592 nonresidents, all of
    whom allegedly were prescribed and ingested Plavix, a drug created and marketed
    by BMS, and as a result suffered adverse consequences. BMS contests the
    propriety of a California court‘s exercising personal jurisdiction over it for
    purposes of adjudicating the nonresident plaintiffs‘ claims.
    Under the particular circumstances present here, we conclude personal
    jurisdiction is authorized by Code of Civil Procedure section 410.10, which
    SEE DISSENTING OPINION
    extends jurisdiction to the maximum extent permissible under the United States
    Constitution. Although BMS‘s business contacts in California are insufficient to
    invoke general jurisdiction, which permits the exercise of jurisdiction over a
    defendant regardless of the subject of the litigation, we conclude the company‘s
    California activities are sufficiently related to the nonresident plaintiffs‘ suits to
    support the invocation of specific jurisdiction, under which personal jurisdiction is
    limited to specific litigation related to the defendant‘s state contacts. (See Vons
    Companies, Inc. v. Seabest Foods, Inc. (1996) 
    14 Cal.4th 434
    , 446 (Vons).)
    Accordingly, we affirm the judgment of the Court of Appeal, which held
    that BMS was subject to the personal jurisdiction of the California courts on the
    basis of specific jurisdiction.
    I. FACTUAL AND PROCEDURAL BACKGROUND
    BMS manufactures Plavix, a prescription drug used to inhibit blood
    clotting. In the eight amended complaints filed in the superior court, 86 California
    residents and 592 residents of 33 other states sued BMS and McKesson
    Corporation, a pharmaceutical distributor headquartered in California, for injuries
    allegedly arising out of their use of Plavix.1 The state in which the largest number
    of plaintiffs reside is Texas, with 92 plaintiffs, followed by the 86 California
    plaintiffs, followed by Ohio, with 71 plaintiffs.
    Each amended complaint contains the same 13 causes of action: strict
    products liability (based on both design defect and manufacturing defect);
    negligence; breach of implied warranty; breach of express warranty; deceit by
    1       A ninth case, filed in Santa Clara Superior Court by the County of Santa
    Clara against defendants was also joined with the other eight cases and assigned to
    a coordination trial judge of the San Francisco Superior Court. The complaint
    filed in that matter is not in the record before us nor is it a subject of dispute
    among the parties as to matters of personal jurisdiction.
    2
    concealment (Civ. Code, §§ 1709, 1710); negligent misrepresentation; fraud by
    concealment; unfair competition (Bus. & Prof. Code, § 17200); false or misleading
    advertising (Bus. & Prof. Code, § 17500); injunctive relief for false or misleading
    advertising (Civ. Code, § 1750 et. seq.); wrongful death; and loss of consortium.
    The plaintiffs allege that defendants engaged in ―negligent and wrongful
    conduct in connection with the design, development, manufacture, testing,
    packaging, promoting, marketing, distribution, labeling, and/or sale of Plavix.‖
    According to the complaints, defendants allegedly promoted the drug to
    consumers and physicians by falsely representing it ―as providing greater
    cardiovascular benefits, while being safer and easier on a person‘s stomach than
    aspirin,‖ but defendants knew those claims were untrue because ingesting Plavix
    allegedly involves ―the risk of suffering a heart attack, stroke, internal bleeding,
    blood disorder or death [which] far outweighs any potential benefit.‖
    Plaintiffs allege different injuries, and sometimes combinations of injuries,
    which they claim were caused from the ingestion of Plavix. These injuries include
    bleeding, bleeding ulcers, gastrointestinal bleeding, cerebral bleeding, rectal
    bleeding, heart attack, stroke, hemorrhagic stroke, subdural hematoma, thrombotic
    thrombocytopenic purpura, and death. The complaints allege that 18 of the 678
    individuals whose injuries underlay these actions died as the result of ingesting
    Plavix.
    The actions were assigned as a coordinated matter to a judge of the San
    Francisco Superior Court.
    BMS moved to quash service of summons on the ground that the court
    lacked personal jurisdiction over it to adjudicate the claims of the 592 nonresident
    plaintiffs, who are real parties in interest in this proceeding (hereafter referred to
    as ―the nonresident plaintiffs‖). BMS noted that the complaints‘ allegations do not
    3
    include any factual claims that the nonresident plaintiffs‘ injuries occurred in
    California or that they had been treated for their injuries in California.
    In declarations supporting the motion, BMS officers stated that the
    company is incorporated in Delaware, is headquartered in New York City, and
    maintains substantial operations in New Jersey, including major research and
    development campuses. BMS has approximately 6,475 employees in the New
    York and New Jersey area, comprising 51 percent of its United States workforce.
    BMS further asserted that its research and development of Plavix did not
    take place in California, nor was any work related to its labeling, packaging,
    regulatory approval, or its advertising or marketing strategy performed by any of
    its employees in this state. BMS has never manufactured Plavix in California.
    These activities were instead performed or directed from the company‘s New
    York headquarters and New Jersey operating facilities. According to data
    provided by the company, in a 12-month period ending in July 2012, BMS‘s sales
    revenue from Plavix sales in California constituted 1.1 percent of the company‘s
    total nationwide sales revenue of all of its products.
    But the declarations submitted by BMS also disclosed that the company
    maintains substantial operations in California, including five offices that are
    primarily research and laboratory facilities employing approximately 164 people.
    BMS additionally employs approximately 250 sales representatives in the state.
    BMS also has a small office in Sacramento to represent and advocate for the
    company in state government affairs.
    In opposition to the motion to quash, plaintiffs submitted materials showing
    that BMS sold almost 187 million Plavix pills to distributors and wholesalers in
    California in 2006-2012, with sales revenue of almost $918 million. Furthermore,
    plaintiffs noted that BMS maintains a registered agent for service of process in
    California.
    4
    The superior court denied BMS‘s motion to quash service of summons,
    concluding the company‘s sales and other activities in California were sufficiently
    extensive to subject it to the general jurisdiction of the state courts.
    BMS petitioned the Court of Appeal for a writ of mandate, naming the
    nonresident plaintiffs as real parties in interest. The Court of Appeal first
    summarily denied the petition on the same day as the United States Supreme Court
    announced its decision in Daimler AG v. Bauman (2014) 571 U.S. ___ [
    134 S.Ct. 746
    ] (Daimler), which clarified limits on general jurisdiction. We granted review
    and transferred the matter back to the Court of Appeal for issuance of an order to
    show cause in light of Daimler. After briefing and oral argument, the Court of
    Appeal again denied the writ, this time by an opinion holding that BMS‘s
    activities in California were insufficient to subject it to general jurisdiction in the
    state, but that, given the nature of the action and BMS‘s activities in California,
    our courts may properly exercise specific jurisdiction over BMS in this matter.
    We granted BMS‘s petition for review, requesting briefing on both types of
    personal jurisdiction, general and specific.
    II. DISCUSSION
    Under Code of Civil Procedure section 410.10, California courts ―may
    exercise jurisdiction on any basis not inconsistent with the Constitution of this
    state or of the United States.‖ ―The Due Process Clause of the Fourteenth
    Amendment constrains a State‘s authority to bind a nonresident defendant to a
    judgment of its courts.‖ (Walden v. Fiore (2014) 571 U.S. ___, ___ [
    134 S.Ct. 1115
    , 1121].) ―Due process limits on the State‘s adjudicative authority principally
    protect the liberty of the nonresident defendant — not the convenience of plaintiffs
    or third parties.‖ (Id. at p. ___ [134 S.Ct. at p. 1122].)
    Under the federal Constitution, a court exercising jurisdiction over a
    nonresident defendant comports with due process as long as the defendant ―has
    5
    such minimum contacts with the state that the assertion of jurisdiction does not
    violate ‗ ―traditional notions of fair play and substantial justice.‖ ‘ ‖ (Vons, supra,
    14 Cal.4th at p. 444, quoting International Shoe Co. v. Washington (1945) 
    326 U.S. 310
    , 316 (International Shoe).) Plaintiffs bear the initial burden of proving
    state contacts sufficient to justify the exercise of jurisdiction. (Vons, 
    supra,
     14
    Cal.4th at p. 449.) The jurisdiction of courts to render judgment against a person
    is historically grounded in the courts‘ power over the person, originally premised
    on a person‘s presence within the territorial jurisdiction of the court.
    (International Shoe, 
    supra,
     326 U.S. at p. 316.) Because ―the corporate
    personality is a fiction,‖ however, a corporation‘s ― ‗presence‘ ‖ in a state must be
    determined by the activities of its agents (ibid.), and the demands of due process in
    this context ―may be met by such contacts of the corporation with the state of the
    forum as make it reasonable, in the context of our federal system of government,
    to require the corporation to defend the particular suit which is brought there.‖
    (Id. at p. 317.)
    In some cases, the corporation‘s continuous activities within the state have
    been found ―so substantial and of such a nature as to justify suit against it on
    causes of action arising from dealings entirely distinct from those activities.‖
    (International Shoe, supra, 326 U.S. at p. 318.) This has become known as
    ―general,‖ or ―all-purpose,‖ jurisdiction. (Daimler, 
    supra,
     571 U.S. ___ [
    134 S.Ct. 746
    , 751, 754].)
    In other circumstances, where the company‘s activities in the forum state are
    more limited, general jurisdiction may be lacking but jurisdiction may nonetheless
    be proper because the litigation is derived from obligations that ―arise out of or are
    connected with the [company‘s] activities within the state.‖ (International Shoe,
    
    supra,
     326 U.S. at pp. 319, 320.) This has become known as ―specific,‖ or ―case-
    linked,‖ jurisdiction. (Daimler, 
    supra,
     571 U.S. at p. ___ [134 S.Ct. at pp. 751,
    6
    754]; Goodyear Dunlop Tires Operations, S.A. v. Brown (2011) 564 U.S. ___, ___
    [
    131 S.Ct. 2846
    , 2851] (Goodyear).)
    ―When a defendant moves to quash service of process on jurisdictional
    grounds, the plaintiff has the initial burden of demonstrating facts justifying the
    exercise of jurisdiction. [Citation.] Once facts showing minimum contacts with
    the forum state are established, however, it becomes the defendant‘s burden to
    demonstrate that the exercise of jurisdiction would be unreasonable. [Citation.]
    When there is conflicting evidence, the trial court‘s factual determinations are not
    disturbed on appeal if supported by substantial evidence. [Citation.] When no
    conflict in the evidence exists, however, the question of jurisdiction is purely one
    of law and the reviewing court engages in an independent review of the record.‖
    (Vons, 
    supra,
     14 Cal.4th at p. 449.)
    Although the briefing and record at the trial court did not have the benefit of
    being informed by the high court‘s decision in Daimler, there appears to be no
    material factual conflicts nor any dispute over any factual findings in the superior
    court. We, therefore, consider the possible exercise of each type of jurisdiction as
    a matter of law and on the undisputed facts.
    A. General Jurisdiction
    1. Case law concerning general jurisdiction
    The landmark 1945 decision of the United States Supreme Court in
    International Shoe, 
    supra,
     
    326 U.S. 310
    , serves as the starting point of modern
    jurisprudence concerning general jurisdiction. Although the high court resolved
    that case under a specific jurisdiction theory, it also described general jurisdiction
    as embracing ―instances in which the continuous corporate operations within a
    state were thought so substantial and of such a nature as to justify suit against it on
    causes of action arising from dealings entirely distinct from those activities.‖
    7
    (International Shoe, supra, 326 U.S. at p. 318.) Subsequent to International Shoe,
    the high court has addressed the concept of general jurisdiction in only a handful
    of cases.
    In Perkins v. Benguet Mining Co. (1952) 
    342 U.S. 437
     (Perkins), the high
    court concluded that a company that had temporarily ceased mining operations
    abroad and had relocated its limited corporate activities to Ohio could be sued in
    Ohio on a cause of action unrelated to its Ohio corporate activities. (Id. at
    pp. 447-448.) In Perkins, because of the wartime Japanese occupation of the
    Philippine Islands, a Philippine corporation had ceased mining operations on all its
    properties there, but it maintained limited corporate activities through its president
    and principal shareholder who had relocated to Ohio. A shareholder then sued the
    company in Ohio for unpaid dividends and for its failure to issue her certificates
    for her shares of stock. The high court applied the standard set forth in
    International Shoe and concluded that the president‘s business activities through
    his home in Ohio reflected ―a continuous and systematic supervision of the
    necessarily limited wartime activities of the company.‖ (Perkins, supra, 342 U.S.
    at p. 448.)
    The high court in Perkins explained that after the company‘s mining
    operations ceased due to the occupation, the president of the company returned to
    his residence in Ohio. He kept a home office there, maintaining the company‘s
    files. From that office he ―carried on correspondence relating to the business of
    the company and to its employees,‖ drew and distributed salary checks on behalf
    of the company, used and maintained two active Ohio bank accounts carrying
    substantial balances of the company‘s funds, retained another Ohio bank to act as
    transfer agent for the stock of the company, held several directors‘ meetings in his
    home or home office, ―supervised policies dealing with the rehabilitation of the
    corporation‘s properties in the Philippines‖ from his Ohio home office, and
    8
    dispatched funds from Ohio to cover purchases of machinery for such
    rehabilitation. (Perkins, supra, 342 U.S. at p. 448.)
    The high court observed that although ―no mining properties in Ohio were
    owned or operated by the company, many of its wartime activities were directed
    from Ohio and were being given the personal attention of its president in that State
    at the time he was served with summons.‖ (Perkins, 
    supra,
     342 U.S. at p. 448.)
    Thus, the company‘s wartime operations had been effectively shifted almost
    entirely to the president‘s home office in Ohio, which meant that ―under the
    circumstances above recited, it would not violate federal due process for Ohio
    either to take or decline jurisdiction of the corporation in this proceeding.‖ (Ibid.)
    In other words, the requirements for the exercise of general jurisdiction were met.
    In Helicopteros Nacionales de Colombia v. Hall (1984) 
    466 U.S. 408
    (Helicopteros), the high court concluded that general jurisdiction was not
    supported in the forum state when the defendant corporation was based abroad,
    had no physical presence in the forum state other than limited business purchases
    and contract negotiations, and the cause of action arose abroad and was unrelated
    to the company‘s contacts with the forum state. In Helicopteros, the survivors of
    four United States citizens, who had died in a helicopter crash in Peru, filed
    wrongful death actions in Texas against the owner and operator of the helicopter, a
    Colombian corporation. (Id. at pp. 409-410.) Prior to the helicopter crash, the
    Colombian corporation had conducted contract negotiations in Texas with the
    decedents‘ Texas employer to provide helicopter services, bought helicopters in
    Texas, and sent employees there for training, but did not conduct other operations
    or maintain a place of business in the state. None of the plaintiffs or their
    decedents resided in Texas. (Id. at pp. 410-412.) The high court concluded that
    neither the negotiation of a single contract and receipt of contractual payment
    through a Texas bank, nor the purchase of helicopters and associated employee
    9
    training sessions in Texas, constituted ―the kind of continuous and systematic
    general business contacts‖ that had justified general jurisdiction in Perkins.
    (Helicopteros at p. 416; see id. at pp. 416-418.)
    More recently, in Goodyear, 
    supra,
     564 U.S. ___ [
    131 S.Ct. 2846
    ], and
    Daimler, 
    supra,
     571 U.S. ___ [
    134 S.Ct. 746
    ], the high court significantly
    elaborated upon its analysis of general jurisdiction, clarifying that in order to
    support the exercise of general jurisdiction over a corporation its contacts with the
    forum state must be so extensive as to render the company essentially ― ‗at
    home‘ ‖ in the state. (Daimler, supra, 571 U.S. at p. ___ [134 S.Ct. at p. 751; see
    Goodyear, 
    supra,
     564 U.S. at p. ___ [131 S.Ct. at p. 2851].) The United States
    Supreme Court‘s description of general jurisdiction for purposes of the federal due
    process clause, as set forth in Goodyear and Daimler, is binding upon us and, as
    explained below, dictates the conclusion that BMS is not subject to the general
    jurisdiction of California courts.
    In Goodyear, the high court concluded that the plaintiffs failed to establish
    support for the exercise of general jurisdiction where the defendant companies
    were based abroad, sold only a limited quantity of their products in the forum
    state, and the cause of action — involving the defendants‘ products sold abroad —
    also arose abroad. In that case, two young men from North Carolina were killed in
    a bus accident outside Paris, France. (Goodyear, supra, 564 U.S. at p. ___ [131
    S.Ct. at p. 2851].) Their parents attributed the accident to an allegedly defective
    tire manufactured by Goodyear‘s subsidiary in Turkey and filed suit in a North
    Carolina state court, naming Goodyear and its subsidiaries in Turkey, France, and
    Luxembourg as defendants. (Id. at pp. ___-___ [131 S.Ct. at pp. 2851-2852].)
    Although a small percentage of their tires was distributed in North Carolina by
    other Goodyear affiliates, the foreign subsidiaries challenged the North Carolina
    court‘s exercise of general jurisdiction over them, contending that they did no
    10
    direct business and employed no workers in North Carolina. (Id. at pp. ___, ___
    [131 S.Ct. at pp. 2850, 2852].)
    The high court first noted that North Carolina courts lacked specific
    jurisdiction to adjudicate the controversy because the accident had occurred
    abroad and the allegedly defective tire had been manufactured and sold abroad.
    (Goodyear, 
    supra,
     564 U.S. at p. ___ [131 S.Ct. at p. 2851].) The court then held
    that the defendant corporations‘ contacts with North Carolina were also
    insufficient for general jurisdiction: ―Unlike the defendant in Perkins, whose sole
    wartime business activity was conducted in Ohio, petitioners are in no sense at
    home in North Carolina. Their attenuated connections to the State . . . fall far
    short of . . . ‗the continuous and systematic general business contacts‘ necessary to
    empower North Carolina to entertain suit against them on claims unrelated to
    anything that connects them to the State.‖ (Goodyear, supra, at p. ___ [131 S.Ct.
    at p. 2857], quoting Helicopteros, 
    supra,
     466 U.S. at p. 416.) The Goodyear court
    explained its ―at home‖ rule for corporations as analogous to a natural person‘s
    domicile in the forum state: ―For an individual, the paradigm forum for the
    exercise of general jurisdiction is the individual‘s domicile; for a corporation, it is
    an equivalent place, one in which the corporation is fairly regarded as at home.‖
    (Goodyear, supra, at p. ___ [131 S.Ct. at pp. 2853-2854].)
    Three years after Goodyear, in Daimler, 
    supra,
     571 U.S. ___ [
    134 S.Ct. 746
    ],
    the court further elaborated on its articulation of the ―at home‖ requirement. In
    Daimler, Argentinian residents brought an action in California against
    DaimlerChrysler AG (DaimlerChrysler), a German public stock company, alleging
    that its wholly owned subsidiary, Mercedes-Benz Argentina, had ―collaborated
    with state security forces to kidnap, detain, torture, and kill‖ the plaintiffs or their
    relatives in Argentina during that nation‘s ― ‗Dirty War.‘ ‖ (Daimler, 
    supra,
     at
    p. ___ [134 S.Ct. at pp. 750-751].) The plaintiffs‘ claim of general jurisdiction
    11
    over DaimlerChrysler in California was based in significant part on the California
    activities of another DaimlerChrysler subsidiary, Mercedes-Benz USA, LLC
    (MBUSA). Although incorporated in Delaware and headquartered in New Jersey,
    MBUSA had substantial facilities in California, using them to import and
    distribute Mercedes-Benz automobiles in the state. (Id. at p. ___ [134 S.Ct. at
    pp. 751-752].)
    Even attributing to DaimlerChrysler the activities of its subsidiary, MBUSA,
    the high court nevertheless found DaimlerChrysler‘s contacts with California
    insufficient to justify the exercise of general jurisdiction over it. (Daimler, supra,
    571 U.S. at p. ___ [134 S.Ct. at p. 760].) The court reiterated its observation in
    Goodyear that a corporation‘s state of incorporation and its principal place of
    business are the two ―paradigm all-purpose forums.‖ (Daimler, 
    supra,
     at p. ___
    [134 S.Ct. at p. 760.) Although it did not limit general jurisdiction to those two
    circumstances, the Daimler court explained that general jurisdiction may not be
    based merely on activities in the forum state that can be characterized as
    continuous and systematic; rather, the corporation‘s activities must be ― ‗so
    ―continuous and systematic‖ as to render [it] essentially at home in the forum
    State.‘ ‖ (Id. at p. ___ [134 S.Ct. at p. 761], quoting Goodyear, supra, 564 U.S. at
    p. ___ [131 S.Ct. at p. 2851].)
    The Daimler court acknowledged that in an exceptional case such as Perkins
    ―a corporation‘s operations in a forum other than its formal place of incorporation
    or principal place of business may be so substantial and of such a nature as to
    render the corporation at home in that State.‖ (Daimler, supra, 571 U.S. at p. ___,
    fn. 19 [134 S.Ct. at p. 761, fn. 19].) The court, however, emphasized the truly
    ― ‗exceptional facts‘ ‖ of Perkins, where ―[g]iven the wartime circumstances, Ohio
    could be considered ‗a surrogate for the place of incorporation or head office.‘ ‖
    (Daimler, 
    supra,
     at p. ___, fn. 8 [134 S.Ct. at p. 756, fn. 8].) DaimlerChrysler‘s
    12
    activities in California, the court observed, ―plainly do not approach that level.‖
    (Id. at p. ___, fn. 19 [134 S.Ct. at p. 761, fn. 19.)
    Furthermore, in responding to a concurring opinion by Justice Sotomayor,
    the Daimler majority made clear that the general jurisdiction inquiry ―does not
    ‗focu[s] solely on the magnitude of the defendant‘s in-state contacts.‘ ‖ (Daimler,
    
    supra,
     571 U.S. at p. ___, fn. 20 [134 S.Ct. at p. 762, fn. 20].) Instead, general
    jurisdiction ―calls for an appraisal of a corporation‘s activities in their entirety,
    nationwide and worldwide.‖ (Ibid.) Otherwise, a corporation with significant
    operations in many states would be deemed at home in all of them. (Ibid.) The
    majority reasoned that to allow the adjudication in California of a dispute arising
    solely in Argentina merely based on MBUSA‘s sales activities in the state would
    give the same global adjudicatory reach to every state in which DaimlerChrysler
    or its subsidiary had sizeable sales. The court rejected such an ―exorbitant
    exercise[] of all-purpose jurisdiction‖ because it would defeat the ability of out-of-
    state defendants to structure their conduct so as to have some predictability
    regarding the possibility of being subjected to litigation in a given forum state.
    (Id. at p. ___ [134 S.Ct. at pp. 761-762].)
    The high court also made clear that because the plaintiffs in Daimler had
    never attempted to argue that California could assert specific jurisdiction over
    DaimlerChrysler, the court had no reason to undertake such an analysis. (Daimler,
    
    supra,
     571 U.S. at p. ___ [134 S.Ct. at p. 758].)
    2. Plaintiffs have failed to show that BMS is subject to general jurisdiction in
    California
    The United States Supreme Court‘s at home rule for general jurisdiction over
    a corporation, as articulated in Goodyear and Daimler, and, to some extent
    Perkins, defeats the nonresident plaintiffs‘ claim that California may assert general
    jurisdiction over BMS. BMS may be regarded as being at home in Delaware,
    13
    where it is incorporated, or perhaps in New York and New Jersey, where it
    maintains its principal business centers. Although the company‘s ongoing
    activities in California are substantial, they fall far short of establishing that is it at
    home in this state for purposes of general jurisdiction.
    Similar to the California subsidiary in Daimler, BMS has sold large volumes
    of its products in California. Nevertheless, the high court plainly rejected the
    theory that a corporation is at home wherever its sales are ―sizeable.‖ (Daimler,
    
    supra,
     571 U.S. at p.___ [134 S.Ct. at p. 761].) BMS employed approximately
    164 people in California in addition to its 250 sales representatives in this state.
    But the company‘s total California operations are much less extensive than its
    activities elsewhere in the United States. As noted earlier, in New York and New
    Jersey alone, BMS employed approximately 6,475 people, 51 percent of its United
    States workforce. In assessing BMS‘s California business activities in comparison
    to the company‘s business operations ―in their entirety, nationwide,‖ we find
    nothing to warrant a conclusion that BMS is at home in California. (Daimler,
    
    supra,
     at p. ___, fn. 20 [134 S.Ct. at p. 762, fn. 20].) As the high court warned in
    Daimler, to conclude that BMS may be sued in California on any cause of action,
    whether or not related to its activities here, under a theory of general jurisdiction,
    would be to extend globally the adjudicatory reach of every state in which the
    company has significant business operations.
    The nonresident plaintiffs stress that in neither Goodyear nor Daimler did the
    high court strictly limit general jurisdiction to a company‘s state of incorporation
    or its principal place of business. Nevertheless, both decisions make clear that the
    suitability of general jurisdiction is rooted in the concept of an individual‘s
    domicile and its equivalent place for a corporation. (Daimler, supra, 571 U.S. at
    p. ___ [134 S.Ct. at p. 760]; Goodyear, 
    supra,
     
    564 U.S. 437
     [131 S.Ct. at
    pp. 2853-2854].) Therefore, setting aside the state of a company‘s incorporation
    14
    or its headquarters, a plaintiff has the burden of showing that a company‘s conduct
    in a given forum state may be so substantial and of such a kind as to render it at
    home there.
    Goodyear and Daimler approved the finding of general jurisdiction in
    Perkins, 
    supra,
     
    342 U.S. 437
    . That case involved the exceptional fact pattern of a
    mining company‘s wartime relocation of its overseas operations to Ohio, which
    functioned as the equivalent of the corporation‘s headquarters through a home
    office in the company president‘s own residence. Quite literally, the mining
    company in Perkins was also at home in this unique context. But nothing in the
    record of the present matter suggests that California has served as the equivalent
    of BMS‘s headquarters, even temporarily.
    The nonresident plaintiffs also rely on the fact that BMS has long been
    registered to do business in California and has maintained an agent for service of
    process here. California law, however, requires a foreign corporation transacting
    business here to name an agent in the state for service of process. (Corp. Code,
    § 2105, subd. (a)(5).) As the high court has explained, ―[t]he purpose of state
    statutes requiring the appointment by foreign corporations of agents upon whom
    process may be served is primarily to subject them to the jurisdiction of local
    courts in controversies growing out of transactions within the State.‖ (Morris &
    Co. v. Ins. Co. (1929) 
    279 U.S. 405
    , 408-409, italics added.) Accordingly, a
    corporation‘s appointment of an agent for service of process, when required by
    state law, cannot compel its surrender to general jurisdiction for disputes unrelated
    to its California transactions. The ―designation of an agent for service of process
    and qualification to do business in California alone are insufficient to permit
    general jurisdiction.‖ (Thomson v. Anderson (2003) 
    113 Cal.App.4th 258
    , 268,
    citing DVI, Inc. v. Superior Court (2002) 
    104 Cal.App.4th 1080
    , 1095; Gray Line
    Tours v. Reynolds Electrical & Engineering Co. (1987) 
    193 Cal.App.3d 190
    , 194.)
    15
    Finally, the nonresident plaintiffs argue BMS is subject to general
    jurisdiction in California because it has contracted for distribution of Plavix with
    McKesson Corporation, which is headquartered in San Francisco, allowing BMS
    ―to make a substantial profit within California through McKesson‘s California
    contacts.‖ As explained above, however, BMS‘s sizeable sales of its products in
    California are insufficient, under Goodyear, supra, 564 U.S. ___ [
    131 S.Ct. 2846
    ]
    and Daimler, 
    supra,
     571 U.S. ___ [
    134 S.Ct. 746
    ], to make it at home in this state
    and subject it to the general jurisdiction of our courts. That some of these sales
    were made to or through a distributor headquartered here does not change the
    analysis.
    As a result, we conclude that BMS is not subject to the general jurisdiction of
    the California courts.
    B. Specific Jurisdiction
    1. Case law concerning specific jurisdiction
    Although the high court‘s recent cases have narrowed the scope of general
    jurisdiction, in Daimler the majority specifically commented on the continued
    viability and breadth of the court‘s preexisting specific jurisdiction jurisprudence.
    In responding to the concern expressed by Justice Sotomayor in her separate
    opinion in Daimler that the court was committing an injustice by limiting the
    availability of general jurisdiction, the majority remarked that ―Justice Sotomayor
    treats specific jurisdiction as though it were barely there‖ and that ―[g]iven the
    many decades in which specific jurisdiction has flourished, it would be hard to
    conjure up an example of the ‗deep injustice‘ Justice Sotomayor predicts as a
    consequence of our holding that California is not an all-purpose forum for suits
    against [DaimlerChrysler].‖ (Daimler, 
    supra,
     571 U.S. at p. ___, fn. 10 [134 S.Ct.
    at p. 758, fn. 10].)
    16
    The basic precepts governing specific jurisdiction set forth in pre-Daimler
    decisions are well settled. In ascertaining the existence of specific jurisdiction,
    courts must analyze the ― ‗relationship among the defendant, the forum, and the
    litigation.‘ ‖ (Helicopteros, 
    supra,
     466 U.S. at p. 414, quoting Shaffer v. Heitner
    (1977) 
    433 U.S. 186
    , 204.) The question of whether a court may exercise specific
    jurisdiction over a nonresident defendant involves examining (1) whether the
    defendant has ― ‗purposefully directed‘ ‖ its activities at the forum state (Keeton v.
    Hustler Magazine, Inc. (1984) 
    465 U.S. 770
    , 774 (Keeton)); (2) whether the
    plaintiff‘s claims arise out of or are related to these forum-directed activities
    (Helicopteros, 
    supra,
     466 U.S. at p. 414); and (3) whether the exercise of
    jurisdiction is reasonable and does not offend ― ‗ ―traditional notions of fair play
    and substantial justice.‖ ‘ ‖ 2 (Asahi Metal Industry Co. v. Superior Court (1987)
    
    480 U.S. 102
    , 113 (Asahi), quoting International Shoe, 
    supra,
     326 U.S. at p. 316.)
    In our own jurisprudence, we have said that a plaintiff has the initial burden
    of demonstrating facts to support the first two factors, which establish the requisite
    minimum contacts with the forum state. The burden then shifts to the defendant to
    show that the exercise of jurisdiction would be unreasonable under the third factor.
    (Snowney v. Harrah’s Entertainment, Inc. (2005) 
    35 Cal.4th 1054
    , 1062
    (Snowney); see also Burger King Corp. v. Rudzewicz (1985) 
    471 U.S. 462
    , 477
    (Burger King) [―where a defendant who purposefully has directed his activities at
    forum residents seeks to defeat jurisdiction, he must present a compelling case that
    2      BMS states it is not contesting the first or third factors and that the
    company is contesting only whether the claims of the nonresident plaintiffs are
    related to its activities in California. But, as we will explain, BMS‘s arguments
    are not as narrow as it contends. Accordingly, we will examine here all three
    factors relevant to the specific jurisdiction analysis.
    17
    the presence of some other considerations would render jurisdiction
    unreasonable‖].)
    Our courts have also explained that the relatedness requirement for specific
    jurisdiction is determined under the ― ‗substantial connection‘ test,‖ which ―is
    satisfied if ‗there is a substantial nexus or connection between the defendant‘s
    forum activities and the plaintiff‘s claim.‘ [Citation.]‖ (Snowney, supra, 35
    Cal.4th at p. 1068.) This test requires courts to evaluate the nature of the
    defendant‘s activities in the forum and the relationship of the claim to those
    activities in order to answer the ultimate question under the due process clause:
    whether the exercise of jurisdiction in the forum is fair. Under the substantial
    connection test, ― ‗the intensity of forum contacts and the connection of the claim
    to those contacts are inversely related.‘ ‖ (Ibid.) ― ‗[T]he more wide ranging the
    defendant‘s forum contacts, the more readily is shown a connection between the
    forum contacts and the claim.‘ [Citation.] Thus, ‗[a] claim need not arise directly
    from the defendant‘s forum contacts in order to be sufficiently related to the
    contact to warrant the exercise of specific jurisdiction.‘ . . . Indeed, ‗ ― ‗[o]nly
    when the operative facts of the controversy are not related to the defendant‘s
    contact with the state can it be said that the cause of action does not arise from that
    [contact].‘ ‖ ‘ [Citation.]‖ (Ibid.) Finally, the defendant‘s activities in the forum
    state need not be either the proximate cause or the ―but for‖ cause of the plaintiff‘s
    injuries. (Ibid.)
    2. Purposeful availment
    As the high court has explained, ―[t]he Due Process Clause protects an
    individual‘s liberty interest in not being subject to the binding judgments of a
    forum with which he has established no meaningful ‗contacts, ties, or relations,‘ ‖
    and that ―[b]y requiring that individuals have ‗fair warning that a particular
    18
    activity may subject [them] to the jurisdiction of a foreign sovereign, ‖‘ the due
    process clause affords predictability and allows potential defendants to tailor their
    conduct ― ‗with some minimum assurance as to where that conduct will and will
    not render them liable to suit.‘ ‖ (Burger King, 
    supra,
     471 U.S. at pp. 471-472.)
    ―Where a forum seeks to assert specific jurisdiction over an out-of-state
    defendant who has not consented to suit there, this ‗fair warning‘ requirement is
    satisfied if the defendant has ‗purposefully directed‘ his activities at residents of
    the forum, [citation], and the litigation results from alleged injuries that ‗arise out
    of or relate to‘ those activities.‖ (Burger King, 
    supra,
     471 U.S. at p. 472, fn.
    omitted.) These activities cannot be the result of the unilateral actions of another
    party or a third person, because the ― ‗purposeful availment‘ requirement ensures
    that a defendant will not be haled into a jurisdiction solely as a result of ‗random,‘
    ‗fortuitous,‘ or ‗attenuated‘ contacts.‖ (Id. at p. 475.) ―When a [nonresident
    defendant] ‗purposefully avails itself of the privilege of conducting activities
    within the forum State,‘ [citation], it has clear notice that it is subject to suit there,
    and can act to alleviate the risk of burdensome litigation by procuring insurance,
    passing the expected costs on to customers, or, if the risks are too great, severing
    its connection with the State.‖ (World-Wide Volkswagen Corp. v. Woodson (1980)
    
    444 U.S. 286
    , 297 (World-Wide Volkswagen).)
    In Snowney, a California resident filed a class action in this state against a
    group of Nevada hotels, alleging several causes of action related to their purported
    failure to provide notice of an energy surcharge imposed on hotel guests.
    (Snowney, 
    supra,
     35 Cal.4th at pp. 1059-1060.) The hotels conducted no business
    and had no bank accounts or employees in California, but they advertised heavily
    in this state using California-based media, including billboards, newspapers, and
    ads aired on radio and television stations, as well as a Web site for room quotes
    19
    and reservations. They also received a significant portion of their business from
    California residents who stayed at their hotels. (Id. at p. 1059.)
    This court held that the Nevada hotels had purposefully availed themselves of
    the privilege of doing business in California because their Web site had touted
    ―the proximity of their hotels to California‖ and provided ―driving directions from
    California to their hotels,‖ thereby ―specifically target[ing] residents of
    California.‖ (Snowney, supra, 35 Cal.4th at p. 1064.) Furthermore, ―[a]side from
    their Web site specifically targeting California residents, defendants advertised
    extensively in California through billboards, newspapers, and radio and television
    stations located in California‖ and ―regularly sent mailings advertising their hotels
    to selected California residents.‖ (Id. at p. 1065.) ―In doing so, defendants
    necessarily availed themselves of the benefits of doing business in California and
    could reasonably expect to be subject to the jurisdiction of courts in California.‖
    (Ibid.)
    In the present matter, there is no question that BMS has purposely availed
    itself of the privilege of conducting activities in California, invoking the benefits
    and protection of its laws, and BMS does not contend otherwise. Not only did
    BMS market and advertise Plavix in this state, it employs sales representatives in
    California, contracted with a California-based pharmaceutical distributor, operates
    research and laboratory facilities in this state, and even has an office in the state
    capital to lobby the state on the company‘s behalf. As in Snowney, supra, 
    35 Cal.4th 1054
    , BMS actively and purposefully sought to promote sales of Plavix to
    California residents, resulting in California sales of nearly $1 billion over six
    years. Moreover, unlike the Nevada hotels in Snowney, BMS maintains a physical
    presence in California, employing well over 400 people here.
    Accordingly, we conclude that BMS has purposefully availed itself of the
    benefits of California such that the first element of the test for specific personal
    20
    jurisdiction is met concerning matters arising from or related to BMS‘s contacts
    with the state. On the basis of these extensive contacts relating to the design,
    marketing, and distribution of Plavix, BMS would be on clear notice that it is
    subject to suit in California concerning such matters. (World-Wide Volkswagen,
    
    supra,
     444 U.S. at p. 19.)
    3. Arises from or is related to
    As previously described, ―for the purpose of establishing jurisdiction the
    intensity of forum contacts and the connection of the claim to those contacts are
    inversely related.‖ (Vons, 
    supra,
     14 Cal.4th at p. 452.) ―[T]he more wide ranging
    the defendant‘s forum contacts, the more readily is shown a connection between
    the forum contacts and the claim.‖ (Id. at p. 455.) Thus, ―[a] claim need not arise
    directly from the defendant‘s forum contacts in order to be sufficiently related to
    the contact to warrant the exercise of specific jurisdiction.‖ (Id. at p. 452.)
    In Vons, we assessed, on relatedness grounds, whether California courts
    could exercise specific jurisdiction over nonresident companies for causes of
    action involving out-of-state injuries that did not arise directly from their
    California contacts. (Vons, 
    supra,
     
    14 Cal.4th 434
    .) The plaintiffs in Vons were
    restaurant franchisees who brought an action for loss of business after
    contaminated hamburger meat caused illnesses in California and Washington,
    resulting in adverse publicity. In California, the franchisees sued two parties: the
    franchisor and the hamburger supplier, Vons Companies, Inc. (Vons), which
    processed hamburger patties in California and supplied them to the franchisor.
    Vons cross-complained against the franchisor and two Washington franchisees,
    suing them for negligence and indemnification for failing to properly cook the
    hamburger meat at restaurants in Washington, causing the injuries and deaths to
    customers there that gave rise to their joint liability with Vons. In Vons, the issue
    21
    was whether the California court had specific jurisdiction over these two
    Washington-based franchisees, Seabest Foods, Inc., and Washington Restaurant
    Management, Inc. (WRMI). (Id. at pp. 440-442.)
    Seabest‘s and WRMI‘s contacts with California included food purchases
    from California suppliers, sending personnel to franchisor training sessions in
    California, remitting franchise payments to California, permitting the franchisor‘s
    inspection of their restaurants by its California-based inspectors, and the
    negotiation of their franchise agreements in California, which agreements stated
    that any disputes would be governed by California law. Because Vons was not a
    party to the franchise contracts for either Seabest or WRMI, those franchisees‘
    contacts with California did not directly give rise to the causes of action asserted
    by Vons. (Vons, supra, 14 Cal.4th at p. 452.) Nevertheless, this court found
    personal jurisdiction was properly exercised over them in California because the
    forum contacts bore a substantial relation to the cause of action. We explained
    that requiring the two Washington franchisees to answer to Vons‘s claim ―is not to
    allow a third party unilaterally to draw them into a connection with the state;
    rather, it was Seabest and WRMI who established the connection.‖ (Id. at p. 451.)
    This court further elaborated: ―A claim need not arise directly from the
    defendant‘s forum contacts in order to be sufficiently related to the contact to
    warrant the exercise of specific jurisdiction. Rather, as long as the claim bears a
    substantial connection to the nonresident‘s forum contacts, the exercise of specific
    jurisdiction is appropriate. The due process clause is concerned with protecting
    nonresident defendants from being brought unfairly into court in the forum, on the
    basis of random contacts. That constitutional provision, however, does not
    provide defendants with a shield against jurisdiction when the defendant
    purposefully has availed himself or herself of benefits in the forum.‖ (Vons,
    supra, 14 Cal.4th at p. 452.)
    22
    In the present matter, plaintiffs allege that BMS negligently designed and
    manufactured Plavix, failed to disclose material information in its advertising and
    promotion of Plavix and fraudulently and falsely advertised and promoted the
    product, and that BMS is liable to those who relied on such representations and
    were injured by Plavix. Their complaints also contend that ―Plavix was heavily
    marketed directly to consumers through television, magazine and internet
    advertising.‖ BMS does not contest that its marketing, promotion, and distribution
    of Plavix was nationwide and was associated with California-based sales
    representatives and a California distributor, McKesson Corporation, which
    plaintiffs allege is jointly liable.
    The California plaintiffs‘ claims concerning the alleged misleading
    marketing and promotion of Plavix and injuries arising out of its distribution to
    and ingestion by California plaintiffs certainly arise from BMS‘s purposeful
    contacts with this state, and BMS does not deny that it can be sued for such claims
    in California. As to the nonresident plaintiffs‘ claims, the Court of Appeal
    understood plaintiffs‘ complaints as alleging that BMS sold Plavix to both the
    California plaintiffs and the nonresident plaintiffs as part of a common nationwide
    course of distribution. BMS has not taken issue with that characterization, nor has
    it asserted that either the product itself or the representations it made about the
    product differed from state to state. Both the resident and nonresident plaintiffs‘
    claims are based on the same allegedly defective product and the assertedly
    misleading marketing and promotion of that product, which allegedly caused
    injuries in and outside the state. Thus, the nonresident plaintiffs‘ claims bear a
    substantial connection to BMS‘s contacts in California. BMS‘s nationwide
    marketing, promotion, and distribution of Plavix created a substantial nexus
    between the nonresident plaintiffs‘ claims and the company‘s contacts in
    California concerning Plavix.
    23
    Plaintiffs also allege that BMS negligently developed and designed Plavix,
    which serves as the basis of its claims of products liability, negligence, and
    breaches of express and implied warranties. BMS maintains research and
    laboratory facilities in California, and it presumably enjoys the protection of our
    laws related to those activities. Although there is no claim that Plavix itself was
    designed and developed in these facilities, the fact that the company engages in
    research and product development in these California facilities is related to
    plaintiffs‘ claims that BMS engaged in a course of conduct of negligent research
    and design that led to their injuries, even if those claims do not arise out of BMS‘s
    research conduct in this state. Accordingly, BMS‘s research and development
    activity in California provides an additional connection between the nonresident
    plaintiffs‘ claims and the company‘s activities in California.
    BMS and our dissenting colleagues attempt to characterize the claims of the
    California plaintiffs as ―parallel‖ to and failing to ―intersect‖ with the nonresident
    plaintiffs‘ claims and argue based on this characterization that BMS‘s conduct in
    California is insufficiently related to the nonresident plaintiffs‘ claims. More
    specifically, BMS contends that the nonresident plaintiffs‘ claims would be
    exactly the same if BMS had no contact whatsoever with California. This
    characterization ignores the uncontested fact that all the plaintiffs‘ claims arise out
    of BMS‘s nationwide marketing and distribution of Plavix. The claims are based
    not on ―similar‖ conduct, as our dissenting colleagues contend, but instead on a
    single, coordinated, nationwide course of conduct directed out of BMS‘s New
    York headquarters and New Jersey operations center and implemented by
    distributors and salespersons across the country. (See Cornelison v. Chaney
    (1976) 
    16 Cal.3d 143
    , 151 [reasoning that the interstate nature of a defendant‘s
    business, while ―not an independent basis of jurisdiction‖ weighs ―in favor of
    requiring him to defend here‖].)
    24
    Moreover, the argument that claims based on a nationwide course of conduct
    fail to establish relatedness for purposes of minimum contacts rests on the invalid
    assumption that BMS‘s forum contacts must bear some substantive legal relevance
    to the nonresident plaintiffs‘ claims, as the dissent explicitly contends. Yet in
    Vons, this court carefully considered and ultimately rejected such a substantive
    relevance requirement. (Vons, supra, 14 Cal.4th at p. 475 [―we conclude that the
    substantive relevance test is inappropriate‖].) Rather, it is sufficient if ―because of
    the defendants‘ relationship with the forum, it is not unfair to require that they
    answer in a California court for an alleged injury that is substantially connected to
    the defendants‘ forum contacts.‖ (Id. at p. 453.) Here, BMS‘s forum contacts,
    including its California-based research and development facilities, are
    substantially connected to the nonresident plaintiffs‘ claims because those contacts
    are part of the nationwide marketing and distribution of Plavix, a drug BMS
    researched and developed, that gave rise to all the plaintiffs‘ claims.
    BMS relies on two cases to contend that California courts may not exercise
    specific jurisdiction over a nonresident defendant sued by a nonresident plaintiff
    for injuries occurring outside the state. But in both cases, the defendant company
    conducted no business in California and had no employees here. (Fisher
    Governor Co. v. Superior Court (1959) 
    53 Cal.2d 222
    , 224 [the defendant had ―no
    employees or property in California and has not appointed an agent to receive
    service of process here‖]; Boaz v. Boyle & Co. (1995) 
    40 Cal.App.4th 700
    , 715
    (Boaz) [the defendant had ―not been licensed to do business in California, and . . .
    had neither salespersons, employees or representatives here, nor any offices, bank
    accounts, records or property in this state‖].)
    Our dissenting colleagues also rely on Boaz and a pharmaceutical case from
    the First Circuit, Glater v. Eli Lilly & Co. (1st Cir. 1984) 
    744 F.2d 213
    , which held
    that specific jurisdiction had not been established because the plaintiff‘s cause of
    25
    action did not ―arise from‖ the company‘s forum activities. (Id at p. 216.)
    Although the facts of Glater are also involve the sales and marketing of an
    allegedly defective drug, the pharmaceutical company‘s contacts with the forum
    state, New Hampshire, appear to have been far less substantial than BMS‘s
    contacts to California. 3
    Moreover, none of these cases had the benefit of our reasoning in Vons,
    where we made clear that we had adopted a sliding scale approach to specific
    jurisdiction in which we recognized that ―the more wide ranging the defendant‘s
    forum contacts, the more readily is shown a connection between the forum
    contacts and the claim.‖ (Vons, 
    supra,
     14 Cal.4th at p. 455.) As previously
    described, BMS‘s contacts with California are substantial and the company has
    enjoyed sizeable revenues from the sales of its product here — the very product
    that is the subject of the claims of all of the plaintiffs. BMS‘s extensive contacts
    with California establish minimum contacts based on a less direct connection
    between BMS‘s forum activities and plaintiffs‘ claims than might otherwise be
    required.
    In sum, taking into account all of BMS‘s activities in this state and their
    relation to the causes of action at issue here, we conclude that the second element
    of specific jurisdiction is met, and hence, absent a showing to the contrary by
    3       In addition, the dissent relies on Hanson v. Denckla (1958) 
    357 U.S. 235
    ,
    where the plaintiffs filed suit in Florida against a Delaware-based trustee who had
    no purposeful contacts with Florida, other than those caused by the unilateral
    activity of the plaintiffs. The dissent‘s reliance on this case is inapposite because
    the high court concluded that the defendant in that matter had not purposefully
    availed herself ―of the privilege of conducting activities within the forum State,
    thus invoking the benefits and protections of its laws.‖ (Id. at p. 253.) Here, the
    parties do not contest that BMS has purposefully availed itself of California law.
    26
    BMS, it would be consistent with due process for it to be subject to litigation in
    this state concerning injuries allegedly caused by its product Plavix, including
    those injuries occurring out of state. Not only did BMS purposefully avail itself of
    the benefits of California by its extensive marketing and distribution of Plavix in
    this state and by contracting with a California distributor and employing hundreds
    of California-based salespersons, resulting in its substantial sales of that product
    here, but the company also maintains significant research and development
    facilities in California. All of plaintiffs‘ claims either arose from these activities
    or are related to those activities. The circumstance that numerous nonresident
    plaintiffs have filed their claims alongside those of resident plaintiffs does not alter
    or detract from this substantial nexus.
    As previously discussed, the due process protections afforded by the doctrine
    of specific jurisdiction are designed to give a potential nonresident defendant
    adequate notice that it is subject to suit there, and, accordingly, a prospective
    defendant can assess the extent of that risk and take measures to mitigate such risk
    or eliminate it entirely by severing its connection with the state. (World-Wide
    Volkswagen, supra, 444 U.S. at p. 297.) Indeed, far from taking measures to
    mitigate the risk of suit in particular forums, BMS embraced this risk by
    coordinating a single nationwide marketing and distribution effort and by
    engaging in research and development in California. In that regard, BMS was on
    notice that it could be sued in California by nonresident plaintiffs. In fact, our
    courts have frequently handled nationwide class actions involving numerous
    nonresident plaintiffs. (See Discover Bank v. Superior Court (2005) 
    36 Cal.4th 148
    ; Washington Mutual Bank v. Superior Court (2001) 
    24 Cal.4th 906
    , 915;
    Diamond Multimedia Systems, Inc. v. Superior Court (1999) 
    19 Cal.4th 1036
    ;
    Rutledge v. Hewlett-Packard Co. (2015) 
    238 Cal.App.4th 1164
    ; Canon U.S.A.,
    Inc. v. Superior Court (1998) 
    68 Cal.App.4th 1
    .)
    27
    To the extent that BMS‘s arguments imply that a California court lacks
    personal jurisdiction over BMS to adjudicate the claims of the nonresident
    plaintiffs simply because the nonresident plaintiffs have no connection to and did
    not suffer any Plavix-related injuries in the state, the high court has repeatedly
    rejected such a focus. The minimum contacts test assesses ―the relationship
    among the defendant, the forum, and the litigation.‖ (Shaffer v. Heitner, 
    supra,
    433 U.S. at p. 204.) As the high court explicitly declared in Keeton, a ―plaintiff‘s
    residence in the forum State is not a separate requirement, and lack of residence
    will not defeat jurisdiction established on the basis of defendant‘s contacts.‖
    (Keeton, 
    supra,
     465 U.S. at p. 780; see also Walden v. Fiore, 
    supra,
     571 U.S. ___,
    ___ [
    134 S.Ct. 1115
    , 1126] [―it is the defendant, not the plaintiff or third parties,
    who must create contacts with the forum State‖]; Helicopteros, 
    supra,
     466 U.S. at
    p. 412, fn. 5 [the plaintiffs‘ ―lack of residential or other contacts with Texas of
    itself does not defeat otherwise proper jurisdiction‖]; Calder v. Jones (1984) 
    465 U.S. 783
    , 788 [the ―plaintiff‘s lack of ‗contacts‘ will not defeat otherwise proper
    jurisdiction‖]; Rush v. Savchuk (1980) 
    444 U.S. 320
    , 332 [―the plaintiff‘s contacts
    with the forum‖ cannot be ―decisive in determining whether the defendant‘s due
    process rights are violated‖]; see also Epic Communications, Inc. v. Richwave
    Technology, Inc. (2009) 
    179 Cal.App.4th 314
    , 336 [―We fail to see how the non-
    California residency of plaintiff can make a ‗compelling case‘ ‖ with respect to
    any of the factors supporting personal jurisdiction].)
    Finally, BMS and our dissenting colleagues further allege that permitting the
    exercise of specific jurisdiction in California for the claims of nonresidents based
    on the company‘s nationwide sales and marketing would effectively subvert the
    holding of Daimler, supra, 571 U.S. ___ [
    134 S.Ct. 746
    ], in which the court
    refused to base jurisdiction merely on nationwide sales. But BMS‘s argument
    overstates the effect of our conclusion that specific jurisdiction is properly
    28
    exercised here. Our decision does not render California an all-purpose forum for
    filing suit against BMS for any matter, regardless of whether the action is related
    to its forum activities. Rather, as with any matter concerning specific jurisdiction,
    the minimum contacts test is applied on a case-by-case basis, focusing on the
    nature and quality of the defendant‘s activities in the state. (Burger King, supra,
    471 U.S. at pp. 474-475.) We simply hold under this specific set of circumstances
    that, for purposes of establishing the requisite minimum contacts, plaintiffs‘ claims
    concerning the allegedly defective design and marketing of Plavix bear a
    substantial nexus with or connection to BMS‘s extensive contacts with California
    as part of Plavix‘s nationwide marketing, its sales of Plavix in this state, and its
    maintenance of research and development facilities here so as to permit specific
    jurisdiction.
    4. The reasonableness of specific jurisdiction
    As previously described, after a plaintiff meets the burden of showing that a
    defendant has purposefully established minimum contacts with the forum state, the
    burden then shifts to the defendant to show that the assertion of specific
    jurisdiction is unreasonable because it does not comport with ― ‗traditional notions
    of fair play and substantial justice.‘ ‖ (International Shoe, supra, 326 U.S. at
    p. 316.) BMS does not argue that the assertion of jurisdiction in this case would
    be fundamentally unfair, but does advance several arguments it contends defeat
    the claim that their causes of action arose from or are related to its contacts with
    California. Analytically, these arguments are more pertinent to consideration of
    whether the exercise of specific jurisdiction is reasonable, not whether the
    contested claims arise from or relate to the company‘s forum activities. The
    questions raised by BMS — whether California has an interest in litigating the
    claims of nonresidents, whether BMS will unfairly bear a disproportionate burden
    29
    of defending itself against all nationwide claims in a single venue of relatively few
    resident plaintiffs, and whether California should expend its judicial resources on
    the claims of nonresident plaintiffs — are all circumstances relevant to the issue of
    whether BMS has established that the exercise of jurisdiction is unreasonable.
    They do not bear upon the issue of whether the nonresident plaintiffs‘ claims arise
    from or are related to BMS‘s activities in the forum state. Accordingly, we will
    examine these arguments using the criteria governing reasonableness.
    In determining whether the defendant has established that the exercise of
    specific jurisdiction is unreasonable, the court ―must consider the burden on the
    defendant, the interests of the forum State, and the plaintiff‘s interest in obtaining
    relief.‖ (Asahi, 
    supra,
     480 U.S. at p. 113.) Although it must also weigh in its
    determination ―the interstate judicial system‘s interest in obtaining the most
    efficient resolution of controversies[,] and the shared interest of the several States
    in furthering fundamental substantive social policies ‖ (World-Wide Volkswagen,
    supra, 444 U.S. at p. 292), a requirement that may ―reflect[] an element of
    federalism and the character of state sovereignty vis-à-vis other States‖ (Insurance
    Corp. v. Compagnie des Bauxites (1982) 
    456 U.S. 694
    , 703, fn. 10), the due
    process clause ―is the only source of the personal jurisdiction requirement.‖ (Id. at
    p. 703, fn. 10.) Accordingly, ―[t]he relationship among the defendant, the forum,
    and the litigation, rather than the mutually exclusive sovereignty of the States . . .
    [is] the central concern of the inquiry into personal jurisdiction.‖ (Shaffer v.
    Heitner, 
    supra,
     433 U.S. at p. 204.)
    a. The burden on defendant in litigating the claims in California
    BMS complains that joining the claims of the nonresident plaintiffs to those
    of the comparatively smaller group of California plaintiffs would unfairly
    distribute the company‘s burden of defending this mass tort action by requiring it
    30
    to defend itself against all nationwide claims in a forum where only a minor
    portion of its sales occurred. However, as the Court of Appeal noted, regardless of
    whether California exercises jurisdiction over nonresident plaintiffs‘ claims, BMS
    is already burdened by having to defend against the claims of 86 California
    plaintiffs. Certainly, the addition of 592 nonresident plaintiffs is a significant
    added burden, but the alternative is to litigate the claims of these other 592
    nonresident plaintiffs in a scattershot manner in various other forums, in
    potentially up to 34 different states.4 Such an alternative would seem to be a far
    more burdensome distribution of BMS‘s resources in defending these cases than
    defending them in a single, focused forum.
    Pretrial preparation and discovery concerning plaintiffs‘ claims may pose
    challenges given the diversity of their states of residence, but, as the Court of
    Appeal recognized, our state‘s Civil Discovery Act provides for taking depositions
    outside California for use at trial. (Code Civ. Proc., § 2026.010.) Moreover,
    information and documents relevant to plaintiffs‘ requests for discovery will likely
    be located in New York or New Jersey, as will the individuals whom plaintiffs are
    likely to seek to depose, regardless of the venue in which the plaintiffs‘ claims are
    filed.
    Finally, BMS has provided no evidence to suggest that the cost of litigating
    plaintiffs‘ claims in San Francisco is excessive or unduly burdensome for BMS
    4       Our dissenting colleagues note that nonresident plaintiffs presumably could
    file their claims in Delaware or perhaps New Jersey or New York, or in federal
    court, where they could be coordinated as part of multidistrict litigation, but
    nothing requires them to choose one of these forums rather than their home states.
    31
    compared to any other relevant forum or forums.5 BMS, therefore, fails to show
    that its defense of plaintiffs‘ claims in California places on it an undue burden.
    b. California’s interest in providing a forum for plaintiffs in this
    case
    BMS further claims that California has no legitimate interest in adjudicating
    the claims of nonresidents because they have no connection to the state.
    Admittedly, the fact that the nonresident plaintiffs greatly outnumber the
    California plaintiffs does give us some pause. But in ascertaining the
    reasonableness of exercising specific jurisdiction, no one factor, by itself, is
    determinative. More important, there are identifiable interests our state holds in
    providing a forum for both the resident and nonresident plaintiffs.
    First, evidence of other injuries is ―admissible to prove a defective condition,
    knowledge, or the cause of an accident,‖ provided that the circumstances of the
    other injuries are similar and not too remote. (Ault v. International Harvester
    (1974) 
    13 Cal.3d 113
    , 121-122; see also Elsworth v. Beech Aircraft Corp. (1984)
    
    37 Cal.3d 540
    , 555 [evidence of prior accidents involving similar airplane with
    identical single-engine stall-spin characteristics was admissible].) To the extent
    that evidence of the injuries allegedly suffered by the nonresident plaintiffs may be
    relevant and admissible to prove that Plavix similarly injured the California
    plaintiffs, trying their cases together with those of nonresident plaintiffs could
    promote efficient adjudication of California residents‘ claims. California,
    therefore, has a clear interest in providing a forum for this matter.
    5       Of course, BMS is free to make such a showing on a motion asserting
    forum non conveniens. (Stangvik v. Shiley Inc. (1991) 
    54 Cal.3d 744
    , 751.) We
    merely hold that, for purposes of defeating specific jurisdiction, BMS fails to meet
    its burden.
    32
    This interest is further underscored by the substantial body of California law
    aimed at protecting consumers from the potential dangers posed by prescription
    medication, including warnings about serious side effects and prohibiting false and
    misleading labeling. (See, e.g., Bus. & Prof. Code, §§ 4070-4078.) As this court
    has previously recognized, ―California has a strong interest in protecting its
    consumers by ensuring that foreign manufacturers comply with the state‘s safety
    standards.‖ (Asahi, 
    supra,
     39 Cal.3d at p. 53.) It also bears reemphasis that there
    are no fewer than 250 BMS sales representatives in California. Although at this
    early stage of the proceedings, the record contains very little evidence concerning
    the promotional and distribution activities of these sales representatives, California
    has a clear interest in regulating their conduct. 6 (Cf. Bus. & Prof. Code, § 17500
    [permitting claims by nonresidents who are deceived by representations
    ―disseminated from‖ the State of California].)
    In addition, California also has an interest in regulating the conduct of
    BMS‘s codefendant, McKesson Corporation, which is headquartered in California,
    as a joint defendant with BMS. As noted above, in Vons, we held that specific
    jurisdiction was proper over cross-defendants who entered into contracts in
    California that gave rise to the joint liability and the corresponding right to
    6       Our dissenting colleagues contend that the record does not establish that
    BMS‘s sales representatives misled nonresident physicians concerning the safety
    and efficacy of Plavix or that McKesson was responsible for providing Plavix to
    any of the nonresident plaintiffs. (Dis. opn. of Werdegar, J., post, at pp. 11-12.)
    Certainly, the existence of such evidence would lend additional support to the
    question of whether the claims of the nonresident plaintiffs are not just related to
    but actually also arise out of BMS‘s contacts with California. But our discussion
    here is merely focused on the reasonableness of asserting specific jurisdiction in
    this matter because our state has an interest in regulating conduct in the
    pharmaceutical industry that could pose a danger to public welfare, regardless of
    residency.
    33
    indemnification on which the cross-claims against them were based. (See Vons,
    supra,14 Cal.4th at pp. 456-457.) California‘s interest in adjudicating claims on
    which McKesson Corporation, a California resident, may be jointly liable with
    BMS, a nonresident defendant, is readily apparent. Were BMS dismissed from
    nonresident plaintiffs‘ cases, California courts would be required to hear their
    claims against McKesson Corporation while the same plaintiffs litigated the same
    claims arising from the same facts and the same evidence against BMS in a forum
    potentially on the opposite side of the country.
    c. Plaintiffs’ interest in a convenient and effective forum
    Nonresident plaintiffs have obviously purposefully availed themselves of the
    jurisdiction of courts in this state by choosing to file all of their claims here —
    strong evidence that the forum is convenient to them. Eighty-six of the 678
    plaintiffs reside in California; only Texas, with 92 plaintiffs, is home to more.
    Moreover, the current forum, San Francisco Superior Court, is equipped with
    a complex litigation department that is well suited to expeditiously handle such
    large cases. BMS has not shown that this forum is inconvenient for plaintiffs.
    d. Judicial economy and the shared interests of the interstate
    judicial system
    BMS argues that it would be a waste of California‘s judicial resources to
    provide a forum for the nonresident plaintiffs. To be sure, a single court hearing
    the claims of hundreds of plaintiffs is a significant burden on that court. But the
    overall savings of time and effort to the judicial system, both in California and
    interstate, far outweigh the burdens placed on the individual forum court. The
    alternative that BMS proposes would result in the duplication of suits in in
    numerous state or federal jurisdictions at substantial costs to both the judicial
    system and to the parties, who would have to deal with disparate rulings on
    otherwise similar procedural and substantive issues.
    34
    For claims of mass injuries stemming from a single product or event,
    plaintiffs often resort to the mechanism of the class action, which promotes
    ―efficiency and economy of litigation.‖ (Crown, Cork & Seal Co. v. Parker (1983)
    
    462 U.S. 345
    , 349.) But, unlike class actions in which common questions of law,
    fact, and proximate cause predominate among members of the plaintiff class,
    ―mass-tort actions for personal injury most often are not appropriate for class
    action certification.‖ (Jolly v. Eli Lilly & Co. (1988) 
    44 Cal.3d 1103
    , 1123.) As
    this court has previously recognized, ―[t]he major elements in tort actions for
    personal injury — liability, causation, and damages — may vary widely from
    claim to claim, creating a wide disparity in claimants‘ damages and issues of
    defendant liability, proximate cause, liability of skilled intermediaries,
    comparative fault, informed consent, assumption of the risk and periods of
    limitation.‖ (Ibid.)
    Yet, because mass tort injuries may involve diverse injuries or harm not
    amenable to the efficiency and economy of a class action, they present special
    problems for the proper functioning of the courts and the fair, efficient, and speedy
    administration of justice. Without coordination, ―those who win the race to the
    courthouse [and] bankrupt a defendant early in the litigation process‖ would
    recover but effectively shut out other potential plaintiffs from any recovery. (In re
    Exxon Valdez (9th Cir. 2000) 
    229 F.3d 790
    , 795-796.) Moreover, coordinated
    mass tort actions ―also avoid the possible unfairness of punishing a defendant over
    and over again for the same tortious conduct.‖ (Id. at p. 796.)
    It is also important to note that many of the resident plaintiffs allege that
    Plavix caused them to suffer heart attacks, strokes, cerebral bleeding, and
    gastrointestinal bleeding. These are obviously severe medical conditions, and
    California has an interest in ensuring that litigation brought by its residents is
    resolved in a timely fashion. By separating the nonresident plaintiffs from the
    35
    resident plaintiffs and forcing the nonresidents to sue in other states, it is fair to
    anticipate delays in the California proceedings that would be created by the
    litigation and appeals of discovery and factual conflicts in the various other
    forums. In that event, the California plaintiffs‘ litigation could be stalled for a
    significant period without resolution. Likewise, defendants would suffer the costs
    created by delay and uncertainty as to their potential liability, if any.
    Moreover, the same concerns of delay and efficiency apply equally to the
    interstate judicial system. The other forums have an equally strong interest in the
    fair, efficient, and speedy administration of justice for both their resident plaintiffs
    and resident defendants. The consolidation of plaintiffs‘ claims in a single forum
    is a mechanism for promoting those interests.
    Of course, the other potential forums also have a sovereign interest in
    seeing their laws applied to actions such as this one. But for purposes of
    establishing the propriety of personal jurisdiction, the high court has stated, ―we
    do not think that such choice-of-law concerns should complicate or distort the
    jurisdictional inquiry.‖ (Keeton, supra, 465 U.S. at p. 778.) Choice-of-law
    concerns might very well make a mass tort action unmanageable in certain
    circumstances, but that issue is not determinative at this stage of the proceedings.
    Accordingly, BMS has failed to carry its burden of showing that the
    exercise of personal jurisdiction over it in this matter is unreasonable.
    III. CONCLUSION
    We conclude that BMS, despite its significant business and research activities
    in California, is not at home in our state for purposes of asserting general personal
    jurisdiction over it. However, we conclude that in light of BMS‘s extensive
    contacts with California, encompassing extensive marketing and distribution of
    Plavix, hundreds of millions of dollars of revenue from Plavix sales, a relationship
    with a California distributor, substantial research and development facilities, and
    36
    hundreds of California employees, courts may, consistent with the requirements of
    due process, exercise specific personal jurisdiction over nonresident plaintiffs‘
    claims in this action, which arise from the same course of conduct that gave rise to
    California plaintiffs‘ claims: BMS‘s development and nationwide marketing and
    distribution of Plavix. BMS cannot establish unfairness: Balancing the burdens
    imposed by this mass tort action, and given its complexity and potential impact on
    the judicial systems of numerous other jurisdictions, we conclude that the joint
    litigation of the nonresident plaintiffs‘ claims with the claims of the California
    plaintiffs is not an unreasonable exercise of specific jurisdiction over defendant
    BMS.
    IV. DISPOSITION
    The judgment of the Court of Appeal is affirmed.
    CANTIL-SAKAUYE, C. J.
    WE CONCUR:
    LIU, J.
    CUÉLLAR, J.
    KRUGER, J.
    37
    DISSENTING OPINION BY WERDEGAR, J.
    The court holds today that 592 plaintiffs residing in states other than
    California may sue Bristol-Myers Squibb Company (BMS) in a California
    superior court for injuries resulting from these plaintiffs‘ use in their own states of
    BMS‘s prescription drug, Plavix. Because BMS is not incorporated or based in
    California, its activities in the state are insufficient to establish general personal
    jurisdiction—jurisdiction for disputes unrelated to the company‘s California
    activities—over it in California courts. (Maj. opn., ante, at p. 2.) The majority,
    however, finds BMS‘s California contacts sufficient for specific, case-related
    personal jurisdiction, even though Plavix was not developed or manufactured in
    California and the nonresident plaintiffs did not obtain the drug through California
    physicians or from a California source, and despite the requirement for specific
    jurisdiction that there be a substantial connection between the plaintiff‘s claim and
    the defendant‘s forum activities. (Id. at pp. 16–28; see Vons Companies, Inc. v.
    Seabest Foods, Inc. (1996) 
    14 Cal.4th 434
    , 452 (Vons).)
    I respectfully dissent from the court‘s decision on personal jurisdiction. I
    agree the extent and type of contacts to support general jurisdiction are lacking.
    But I find in the record no evidence of contacts with California that bear a
    substantial connection to the claims of these nonresidents. I therefore would hold
    specific jurisdiction has also not been established.
    On a defendant‘s motion to quash service of process, the plaintiff asserting
    jurisdiction bears the burden of proving the extent of the defendant‘s forum
    contacts and their relationship to the plaintiff‘s claims. (Vons, supra, 14 Cal.4th at
    p. 449; Gilmore Bank v. AsiaTrust New Zealand Ltd. (2014) 
    223 Cal.App.4th 1558
    , 1568.) In this case, the nonresident plaintiffs (real parties in interest on
    BMS‘s petition for writ of mandate) have failed to show any substantial nexus,
    causal or otherwise, between their claims and BMS‘s activities in California.
    One can imagine a number of factual circumstances that might justify
    specific jurisdiction in a case like this. Unfortunately, none of those circumstances
    have been established here:
    If real parties in interest had purchased Plavix while in California or from a
    California source, their claims could be considered substantially related to BMS‘s
    sale of Plavix in this state. But the record contains no evidence connecting the
    Plavix taken by any of the nonresident plaintiffs to California.
    If real parties had been prescribed Plavix by a California doctor, their
    misrepresentation claims might be considered substantially related to BMS‘s
    marketing of Plavix to physicians here. But there is no evidence of a California
    connection through real parties’ prescribing physicians.
    If the Plavix taken by real parties had been manufactured in California, one
    might well consider their defective product claims substantially connected to
    BMS‘s forum contacts. But the record shows Plavix has never been manufactured
    in California.
    If the Plavix taken by real parties had been distributed to their respective
    states by codefendant McKesson Corporation, which is headquartered in San
    Francisco, it could be argued real parties‘ defective product claims were related to
    the distribution agreement between BMS and McKesson. But real parties have
    2
    adduced no evidence to show how or by whom the Plavix they took was distributed
    to the pharmacies that dispensed it to them.
    If Plavix had been developed in California, real parties‘ defective product
    claims could be considered related to that California activity. But the record
    shows Plavix was developed not in California but in New York and New Jersey,
    where BMS has, respectively, its headquarters and major operating facilities.
    If the labeling, packaging, or regulatory approval of Plavix had been
    performed in or directed from California, some of real parties‘ misrepresentation
    claims would arguably be related to those California activities. But BMS did none
    of those things in California.
    Finally, if the ―nationwide marketing‖ campaign on which the majority relies
    (maj. opn., ante, at p. 27) had been created or directed from California, claims of
    misrepresentations in that marketing would have arisen from BMS‘s California
    contacts. But according to the record, none of that marketing work was performed
    or directed by BMS’s California employees.
    In the absence of a concrete factual relationship between their claims and
    BMS‘s contacts with the forum state, on what do real parties, and the majority of
    this court, base their argument for specific jurisdiction over BMS in California
    courts? In brief, their argument rests on similarity of claims and joinder with
    California plaintiffs. First, real parties‘ claims arise from activities similar to
    those BMS conducted in California, because in marketing and selling Plavix
    throughout the United States, BMS sold the same allegedly defective product in
    California as in real parties‘ various states of residence and presumably made
    some of the same misrepresentations and omissions in those states and in
    California. Second, real parties are joined in this action with plaintiffs who are
    California residents and who allege similar claims. Neither of these factors,
    3
    however, creates a connection between real parties‘ claims of injury and BMS‘s
    California activities sufficient to satisfy due process.
    By statute, the personal jurisdiction of California courts extends to the limits
    set by the state and federal Constitutions. (Code Civ. Proc., § 410.10.)
    Constitutional due process limits dictate that in the absence of general
    jurisdiction—which exists only if a corporation is incorporated in the forum state
    or conducts such intensive activities there as to make it ―at home‖ in that state
    (Goodyear Dunlop Tires Operations, S.A. v. Brown (2011) 
    564 U.S. 915
    , 919
    (Goodyear))—personal jurisdiction over the corporation to adjudicate a particular
    claim (specific jurisdiction) is established only if the controversy ―is related to or
    ‗arises out of‘ ‖ the company‘s activities in the forum state. (Helicopteros
    Nacionales de Colombia v. Hall (1984) 
    466 U.S. 408
    , 414 (Helicopteros).)
    The majority‘s decision is not supported by specific jurisdiction decisions
    from the United States Supreme Court, this court, or the lower federal and state
    courts. (See pt. I, post.) And as I will discuss later (see pt. II, post), today‘s
    decision impairs important functions of reciprocity, predictability, and limited
    state sovereignty served by the relatedness requirement. By weakening the
    relatedness requirement, the majority‘s decision threatens to subject companies to
    the jurisdiction of California courts to an extent unpredictable from their business
    activities in California, extending jurisdiction over claims of liability well beyond
    our state‘s legitimate regulatory interest.
    Just as important, minimizing the relatedness requirement undermines an
    essential distinction between specific and general jurisdiction. In Daimler AG v.
    Bauman (2014) 571 U.S.___, ___ [
    187 L.Ed.2d 624
    , ___, 
    134 S.Ct. 746
    , 751], the
    United States Supreme Court made clear that general jurisdiction—jurisdiction to
    adjudicate controversies unrelated to the defendant‘s forum contacts—is not
    created merely by commercial contacts that are ―continuous and systematic‖
    4
    (Helicopteros, 
    supra,
     466 U.S. at p. 416) but only by contacts so extensive as to
    render the defendant ― ‗at home‘ ‖ in the forum state. (Daimler, 
    supra,
     187
    L.Ed.2d at p. 761.) The majority applies that holding to conclude, correctly, that
    general jurisdiction is lacking here. (Maj. opn., ante, at pp. 13–16.) But by
    reducing relatedness to mere similarity and joinder, the majority expands specific
    jurisdiction to the point that, for a large category of defendants, it becomes
    indistinguishable from general jurisdiction. At least for consumer companies
    operating nationwide, with substantial sales in California, the majority creates the
    equivalent of general jurisdiction in California courts. What the federal high court
    wrought in Daimler—a shift in the general jurisdiction standard from the
    ―continuous and systematic‖ test of Helicopteros to a much tighter ―at home‖
    limit—this court undoes today under the rubric of specific jurisdiction.
    I. The Case Law Does Not Support Specific Jurisdiction in These
    Circumstances
    Specific jurisdiction over a defendant—jurisdiction to adjudicate a dispute
    connected to the defendant‘s contacts with the forum state—depends on the
    relationship among the defendant, the forum, and the litigation. (Helicopteros,
    supra, 466 U.S. at p. 414.) We have summarized the requirements for specific
    jurisdiction as threefold: (1) the defendant has purposefully availed itself of forum
    benefits; (2) the controversy arises out of or is otherwise related to the defendant‘s
    forum contacts; and (3) the assertion of personal jurisdiction in the particular
    litigation is reasonable in light of the burdens and benefits of forum litigation.
    (Snowney v. Harrah’s Entertainment, Inc. (2005) 
    35 Cal.4th 1054
    , 1062
    (Snowney).)
    BMS contests neither the first prong of this tripartite test, that the company
    has purposefully availed itself of forum benefits by its continuous course of
    substantial business activities in California, nor the third, that taking jurisdiction
    5
    would impose unreasonable burdens on the company. (Snowney, supra, 35
    Cal.4th at p. 1070.) The key issue here is therefore whether the claims of the real
    parties in interest (plaintiffs residing in states other than California) arise out of, or
    are otherwise related to, BMS‘s activities in California.
    A. The Relatedness Requirement for Specific Jurisdiction
    The requirement that the litigation be related to the defendant‘s activities in
    or directed to the forum, by which it has purposefully availed itself of the benefits
    of doing business in the state, was first stated in the landmark decision of Internat.
    Shoe Co. v. Washington (1945) 
    326 U.S. 310
     (International Shoe). The high court
    first noted that jurisdiction is well established when a corporation‘s ―continuous
    and systematic‖ activities in the state ―give rise to the liabilities sued on.‖ (Id. at
    p. 317.) Even when a corporation has engaged in only occasional activities in the
    state, due process may still be satisfied if those activities have created the
    obligations sued on: ―[T]o the extent that a corporation exercises the privilege of
    conducting activities within a state, it enjoys the benefits and protection of the
    laws of that state. The exercise of that privilege may give rise to obligations, and,
    so far as those obligations arise out of or are connected with the activities within
    the state, a procedure which requires the corporation to respond to a suit brought
    to enforce them can, in most instances, hardly be said to be undue.‖ (Id. at p.
    319.)
    In International Shoe itself, the relationship between the forum activities and
    the litigation was a straightforward one: The defendant corporation had employed
    salesmen in the State of Washington, which required it contribute to the state‘s
    unemployment compensation fund; the litigation concerned an assessment for
    unpaid contributions. (International Shoe, supra, 326 U.S. at pp. 312–313.) Thus
    ―the obligation which is here sued upon arose out of those very [forum] activities,‖
    6
    making it reasonable for Washington ―to enforce the obligations which appellant
    has incurred there.‖ (Id. at p. 320.)
    The United States Supreme Court has not, since International Shoe, greatly
    elaborated on its understanding of the relatedness requirement. The court in
    Helicopteros slightly reformulated the requirement: jurisdiction may be
    appropriate if the controversy ―arise[s] out of or relate[s] to‖ the company‘s forum
    contacts. (Helicopteros, supra, 466 U.S. at p. 414.) But the high court did not
    explain or apply that standard in Helicopteros, and in Goodyear, 
    supra,
     564 U.S.
    at page 919, the court again used a different formulation, suggesting a narrower
    vision of relatedness: ―Specific jurisdiction . . . depends on an ‗affiliatio[n]
    between the forum and the underlying controversy,‘ principally, activity or an
    occurrence that takes place in the forum State and is therefore subject to the
    State’s regulation.‖ (Italics added.) The Goodyear court went on, very briefly, to
    explain why specific jurisdiction did not exist in the case before it, which involved
    the deaths of two North Carolina boys in an overseas bus accident: ―Because the
    episode-in-suit, the bus accident, occurred in France, and the tire alleged to have
    caused the accident was manufactured and sold abroad, North Carolina courts
    lacked specific jurisdiction to adjudicate the controversy.‖ (Ibid.) None of the
    injury-causing events having occurred in the forum state, the basis for specific
    jurisdiction was lacking.
    Of the post- International Shoe decisions in which the high court actually
    found a factual basis for specific jurisdiction, each featured a direct link between
    forum activities and the litigation. (See Burger King Corp. v. Rudzewicz (1985)
    
    471 U.S. 462
    , 479–480 [specific jurisdiction in Florida courts proper where
    franchise dispute ―grew directly out of‖ contract formed between Florida
    franchisor and Michigan franchisee, whose breach ―caused foreseeable injuries to
    the corporation in Florida‖]; Calder v. Jones (1984) 
    465 U.S. 783
    , 789 [California
    7
    jurisdiction over writer and editor based in Florida proper for article distributed in
    California and defaming California resident, where the defendants‘ ―intentional,
    and allegedly tortious, actions were expressly aimed at California‖ and they knew
    article ―would have a potentially devastating impact‖ on California resident];
    Keeton v. Hustler Magazine, Inc. (1984) 
    465 U.S. 770
    , 776–777 (Keeton) [specific
    jurisdiction in New Hampshire courts proper over Ohio corporation where
    corporation‘s sale in New Hampshire of magazine defaming the plaintiff injured
    her reputation in that state]; McGee v. International Life Ins. Co. (1957) 
    355 U.S. 220
    , 223 [specific jurisdiction in California courts proper where action was based
    on a life insurance contract delivered in California and on which the insured, a
    California resident at his death, had paid premiums from the state].) Nothing in
    the high court‘s specific jurisdiction decisions suggests an abandonment or broad
    relaxation of the relatedness requirement.
    This court did, in Vons, adopt a relatively broad standard for relatedness.
    After canvassing formulations put forward by scholars and lower courts, we held
    the relationship between the defendant‘s forum contacts and the plaintiff‘s claims
    in litigation need not be one of proximate legal causation or even ―but for‖ factual
    causation, nor need the forum contacts be substantively relevant in the plaintiff‘s
    action. (Vons, supra, 14 Cal.4th at pp. 460–475.) Rather, the relationship required
    for specific jurisdiction exists if the claims bear a ―substantial nexus or
    connection‖ to the activities by which the defendant has purposefully availed itself
    of forum benefits. (Id. at p. 456; accord, Snowney, 
    supra,
     35 Cal.4th at pp. 1067–
    1068.) The test is not a mechanical one, but a weighing process in which ―the
    greater the intensity of forum activity, the lesser the relationship required between
    the contact and the claim.‖ (Vons, 
    supra, at p. 453
    ; accord, Snowney, 
    supra, at p. 1068
    .) Specific jurisdiction in California courts is proper if ―because of the
    defendants‘ relationship with the forum, it is not unfair to require that they answer
    8
    in a California court for an alleged injury that is substantially connected to the
    defendants‘ forum contacts.‖ (Vons, 
    supra, at p. 453
    .)
    Notwithstanding our relatively broad substantial connection standard, mere
    similarity of claims is an insufficient basis for specific jurisdiction. The claims of
    real parties in interest, nonresidents injured by their use of Plavix they purchased
    and used in other states, in no sense arise from BMS‘s marketing and sales of
    Plavix in California, or from any of BMS‘s other activities in this state. Nor is any
    other substantial connection apparent.
    BMS promoted and sold Plavix in this state, giving rise to the California
    plaintiffs‘ claims. BMS also engaged in such promotion and sales in many other
    states, giving rise to claims by residents of those states. As all the claims derive
    from similar conduct and allege similar injuries, the nonresident plaintiffs‘ claims
    closely resemble those made by California residents. But I can perceive no
    substantial nexus between the nonresidents‘ claims and BMS‘s California
    activities. In each state, the company‘s activities are connected to claims by those
    who obtained Plavix or were injured in that state, but no relationship other than
    similarity runs between the claims made in different states. As BMS argues, its
    California contacts fail to ―intersect‖ with the nonresident plaintiffs‘ claims.
    Even a commentator ―sympathetic to an expanded role for specific
    jurisdiction‖ found the approach of the Court of Appeal in this case, which the
    majority in this court largely replicates, so overly broad as ―to reintroduce general
    jurisdiction by another name.‖ (Silberman, The End of Another Era: Reflections
    on Daimler and Its Implications for Judicial Jurisdiction in the United States
    (2015) 19 Lewis & Clark L.Rev. 675, 687 (hereafter Silberman).) ―A more
    plausible specific jurisdiction forum might be the state where the drugs were
    manufactured or distributed to both the California and non-California plaintiffs; all
    plaintiffs‘ claims might be said to ‗arise from‘ such defective manufacture and
    9
    thereby provide an alternative single forum in which to have all the plaintiffs
    assert their claims. In Bristol-Meyers [sic], no such connection to California can
    be established for the non-California plaintiffs. The claims of the California and
    nonresident plaintiffs are merely parallel.‖ (Ibid., fn. omitted.)
    One form of substantial connection between a defendant‘s forum activities
    and the claims against it exists when the forum activities are legally relevant to
    establish the claims. (Vons, supra, 14 Cal.4th at p. 469.) In that situation, the
    forum state‘s interest in regulating conduct occurring within its borders is
    implicated, as the plaintiff is seeking to impose liability, at least in part, for acts
    the defendant committed in the forum state. (Id. at p. 472.) But no such legal
    relevance connection is apparent here. The nonresident plaintiffs‘ claims rest on
    allegations that BMS deceptively marketed and sold Plavix to them or their
    prescribing physicians, but, as noted earlier, the record is devoid of any
    suggestion, nor do real parties claim, the nonresident plaintiffs bought or were
    prescribed Plavix from a California source. BMS‘s marketing and sales activities
    in California thus appear irrelevant to real parties‘ claims. To quote BMS‘s brief,
    the nonresident plaintiffs‘ claims ―would be exactly the same if BMS had never
    set foot in California, had never engaged in any commercial activity in California,
    had never sold any product here, and had engaged only non-California
    distributors.‖
    In addition to its interest in regulating conduct within its borders, each state
    has an interest in providing a judicial forum for its injured residents, regardless of
    whether the conduct sued on occurred in the state. (Vons, 
    supra,
     14 Cal.4th at
    pp. 472–473.) ―[T]he state has a legitimate interest as sovereign in providing its
    residents with protection from injuries caused by nonresidents and with a forum in
    which to seek redress. This assertion of sovereignty with respect to nonresident
    defendants is fair when those defendants have availed themselves of certain
    10
    benefits within the state and the claim is related to those contacts.‖ (Id. at p. 473.)
    But reference to the state‘s interest in providing a forum for its residents to seek
    legal redress is of no help to real parties in interest here, as they are not California
    residents. California has no discernable sovereign interest in providing an Ohio or
    South Carolina resident a forum in which to seek redress for injuries in those states
    caused by conduct occurring outside California. A mere resemblance between the
    nonresident plaintiffs‘ claims and those of California residents creates no
    sovereign interest in litigating those claims in a forum to which they have no
    substantial connection.
    The majority argues that taking jurisdiction over the nonresidents‘ claims
    furthers a California interest because evidence of their injuries may be admissible
    to help the California plaintiffs prove Plavix was a defective product. (Maj. opn.,
    ante, at p. 32.) But admissibility of other injuries does not depend on joinder of
    the other injured person, as the cases the majority cites illustrate. In neither Ault v.
    International Harvester (1974) 
    13 Cal.3d 113
     nor Elsworth v. Beech Aircraft
    Corp. (1984) 
    37 Cal.3d 540
    , where evidence of prior similar injuries was held
    admissible, were those injured in the prior accidents joined as parties in the action.
    The majority also suggests that jurisdiction over the nonresidents‘ claims is
    proper because California law attempts to ―protect[] consumers from the potential
    dangers posed by prescription medication.‖ (Maj. opn., ante, at p. 33.) The
    statutes cited, however, regulate the dispensing of prescription drugs by California
    pharmacists (Bus. & Prof. Code, §§ 4070–4078), while the claims at issue in this
    case are against BMS, a drug manufacturer. Moreover, real parties in interest have
    neither alleged nor proven they were prescribed or furnished Plavix in California.
    How the cited California laws might apply to their claims is thus unclear, to say
    the least.
    11
    In the same passage, the majority implies that the activity of BMS‘s
    California sales representatives, whose representations California has an interest in
    regulating, might somehow be related to real parties‘ claims. (Maj. opn., ante, at
    p. 33.) In this instance as well, the majority ignores the complete absence of
    evidence showing any such relationship. Real parties in interest, who have the
    burden of proving forum contacts related to their claims, have not even attempted
    to establish that sales representatives in California misled physicians in other
    states about Plavix‘s efficacy and safety. While no doubt correct California has an
    interest in regulating dangerous conduct within our state (maj. opn, ante, p. 33, fn.
    6), the majority neglects to explain how that interest can be served by taking
    jurisdiction to adjudicate the claims of persons unaffected by any such conduct.
    Finally, the majority asserts that California‘s interest in regulating the
    conduct of codefendant McKesson Corporation (McKesson), a pharmaceutical
    distributor headquartered in California, justifies adjudicating real parties‘ claims
    against BMS in a California court. (Maj. opn., ante, at pp. 33–34.) Of all the
    majority‘s red herrings, this is perhaps the ruddiest. Why plaintiffs sued
    McKesson as well as BMS is not obvious—BMS suggests it was merely to avoid
    removal to federal court (see 
    28 U.S.C. § 1441
    (b)(2))—but at no point have real
    parties argued McKesson bore any responsibility in providing them with Plavix.
    In their brief on the merits, real parties contended BMS‘s relationship with
    McKesson helped BMS make substantial profits ―within California,‖ and at oral
    argument their attorney acknowledged he had no evidence tying McKesson to the
    Plavix that allegedly injured real parties outside this state. The notion of a
    connection between McKesson‘s conduct in California and the claims of real
    parties in interest, which arise from their acquisition and use of Plavix in other
    states, is purely a product of the majority‘s imagination.
    12
    Notwithstanding the majority‘s speculative suggestions, as far as the record
    shows real parties‘ claims arise solely from conduct in other states and do not
    implicate California‘s legitimate interest in regulating conduct within its borders.
    B. Jurisdiction Over Liability Claims for Pharmaceutical Drugs
    Neither real parties in interest nor the majority cites any decision, state or
    federal, finding specific jurisdiction on facts similar to those here. In fact, courts
    in both systems have rejected jurisdiction over drug defect claims made by
    plaintiffs who neither reside in nor were injured by conduct in the forum state.
    In Boaz v. Boyle & Co. (1995) 
    40 Cal.App.4th 700
     (Boaz), a group of
    plaintiffs, mostly residents of New York and New Jersey, but including one
    California resident, sued several manufacturers of the drug DES for injuries
    allegedly resulting from their grandmothers‘ ingestion of the drug in New York.
    (Id. at p. 704.) The appellate court affirmed the dismissal of the action against
    defendant Emons Industries, Inc., which was not subject to California‘s general
    jurisdiction, holding the basis for specific jurisdiction was also lacking as the
    defendant‘s activities in California were unrelated to the plaintiffs‘ injuries. (Id. at
    p. 705.) ―It is conceded that none of appellants‘ grandmothers, who ingested DES,
    did so in California. Nor did any of them acquire the product as the result of any
    of Emons‘s activities related to California. Indeed, as we have seen, none of them
    except [the single California resident] has any connection with this state.‖ (Id. at
    p. 718.) Though the defendant had sold DES in California as it had in other states,
    that similarity of conduct did not subject it to personal jurisdiction for the purposes
    of adjudicating the out-of-state plaintiffs‘ claims, though, as the court noted,
    jurisdiction might be appropriate ―in a case arising out of ingestion in California or
    13
    by purchase or prescription in California of DES.‖ (Id. at p. 721.)1 As in the
    present case, none of those facts had been or could be established.
    Glater v. Eli Lilly & Co. (1st Cir. 1984) 
    744 F.2d 213
    , presented a similar
    fact pattern in an individual suit. The plaintiff there sued a DES manufacturer in a
    federal court in New Hampshire for injuries she allegedly suffered from in utero
    exposure to the drug. The plaintiff‘s mother took the drug in Massachusetts,
    where she lived. (Id. at p. 214.) That the manufacturer had marketed DES
    nationwide, including in New Hampshire, was insufficient to support specific
    jurisdiction: Although Lilly marketed and sold DES nationwide, including in New
    Hampshire, ―Glater‘s cause of action did not arise from Lilly‘s New Hampshire
    activities; rather, her injuries were caused in Massachusetts by exposure in utero
    to DES which her mother purchased and consumed in Massachusetts.‖ (Id. at
    p. 216.) Were the defendant‘s New Hampshire contacts deemed sufficiently
    related to the cause of action arising in Massachusetts, the court ―would be obliged
    to hold that any plaintiff in Glater‘s position—a nonresident injured out of state by
    a drug sold and consumed out of state—could bring suit in New Hampshire for
    DES injuries.‖ (Id. at p. 216, fn. 4.) Such ―retributive jurisdiction‖ over claims
    1       As to the California resident, the Boaz court reasoned jurisdiction was
    lacking because her grandmother had not taken DES in California and therefore
    ―any DES-related affliction she suffers has nothing to do with any of Emons‘s
    activities related to California.‖ (Boaz, supra, 40 Cal.App.4th at p. 718.) The
    court may have gone too far in this respect; California‘s interest in providing a
    forum for its residents to seek redress for actions having injurious effects in the
    state arguably justified specific jurisdiction over the California resident‘s claims.
    For the same reason, In re DES Cases (E.D.N.Y. 1992) 
    789 F.Supp. 552
     can be
    distinguished as involving the claims of New York residents seeking a remedy for
    injuries occurring in New York; although the defendants challenging jurisdiction
    there did not market DES in New York, they bore legal responsibility for injuries
    there under the state‘s rule of market share liability. (See 
    id.
     at pp. 592–593.)
    14
    unconnected to the forum ―comports with neither logic nor fairness.‖ (Ibid.;
    accord, Seymour v. Parke, Davis & Company (1st Cir. 1970) 
    423 F.2d 584
    , 585,
    587 [suit in New Hampshire over drug taken and allegedly causing injury in
    Massachusetts ―did not arise [in New Hampshire], or as a result of anything which
    occurred there‖ and hence was an ―unconnected cause[] of action‖ that could only
    be justified by general jurisdiction, the basis for which was also lacking].)
    Also similar, though less extensively reasoned as to specific jurisdiction, is
    Ratliff v. Cooper Laboratories, Inc. (4th Cir. 1971) 
    444 F.2d 745
    . That decision
    addressed two consolidated cases brought in a federal court in South Carolina,
    both by residents of other states who bought and consumed the allegedly harmful
    drugs (not named in the decision), against drug manufacturers that conducted
    business in South Carolina but were not incorporated or headquartered there and
    had not made the subject drugs there. (Id. at p. 746.) The court observed that the
    plaintiffs were not residents of South Carolina and their causes of action ―arose
    outside the forum and were unconnected with the defendant‘s activities in South
    Carolina.‖ (Id. at p. 747.) Noting ―the lack of a ‗rational nexus‘ between the
    forum state and the relevant facts surrounding the claims presented‖ such as would
    support specific jurisdiction, the court moved on to general jurisdiction (for which
    it also found the forum contacts insufficient). (Id. at p. 748.)
    In all these cases, the defendants had sold their pharmaceutical drugs in the
    forum state. Indeed, in Boaz, California physicians accounted for 9 percent of the
    defendant‘s DES sales. (Boaz, supra, 40 Cal.App.4th at p. 715.)2 Yet these
    2      The majority (maj. opn., ante, at p. 25) notes that the defendant in Boaz,
    unlike BMS, did not employ salespeople or maintain offices in the state. Yet
    through ―advertising in selected professional magazines and professional journals,
    and targeted mailings of samples and brochures to obstetricians and
    gynecologists,‖ all ―done on a national scale‖ (Boaz, supra, 40 Cal.App.4th at
    (footnote continued on next page)
    15
    courts— correctly, in my view— considered that forum activity to be unconnected
    to the plaintiffs‘ claims, which arose from use of the drugs in other states. Not
    until today‘s decision has specific jurisdiction over a drug liability claim arising
    from the nonresident plaintiff‘s purchase, use, and injury outside the forum state
    been premised on the fact that the defendant also sold the drug in the forum state.
    C. Specific Jurisdiction Decisions Relied on by Real Parties
    Turning from pharmaceutical liability to the broader case law, we see that
    none of the decisions real parties cite support specific jurisdiction based, as here,
    on the mere resemblance between the disputed claims and distinct claims brought
    by other plaintiffs that arose from the defendant‘s forum contacts. Each of these
    cited cases involved a substantial connection between the defendant‘s activities in
    the forum state and the plaintiff‘s claims, not merely a connection between the
    forum activities and similar claims made by other plaintiffs.
    In Cornelison v. Chaney (1976) 
    16 Cal.3d 143
     (Cornelison), a California
    resident sued for the wrongful death of her husband, who died in an automobile
    accident in Nevada. The defendant, a Nebraska resident, was a trucker hauling
    goods in interstate commerce. He made approximately 20 trips to California each
    year and was en route to this state with a shipment when his truck collided with
    the decedent‘s vehicle in Nevada, near the California border. (Id. at pp. 146–147.)
    We concluded the plaintiff‘s cause of action did bear a substantial connection
    to the defendant‘s business activities in California: ―As we have seen, defendant
    (footnote continued from previous page)
    p. 715), the company sold a large amount of DES—the same product at issue in
    the disputed lawsuits—in California. Like BMS, then, the defendant in Boaz
    ―enjoyed sizeable revenues from the sales of its product here.‖ (Maj. opn., ante, at
    p. 26.) Why the absence of other, dissimilar ties should serve to distinguish the
    case is unclear.
    16
    has been engaged in a continuous course of conduct that has brought him into the
    state almost twice a month for seven years as a trucker under a California license.
    The accident occurred not far from the California border, while defendant was
    bound for this state. He was not only bringing goods into California for a local
    manufacturer, but he intended to receive merchandise here for delivery elsewhere.
    The accident arose out of the driving of the truck, the very activity which was the
    essential basis of defendant‘s contacts with this state. These factors demonstrate,
    in our view, a substantial nexus between plaintiff‘s cause of action and
    defendant‘s activities in California.‖ (Cornelison, supra, 16 Cal.3d at p. 149.) In
    further support, we observed that California had an interest in providing a forum
    for the litigation because the plaintiff was a California resident. (Id. at p. 151.)
    Cornelison has in common with the present case that the plaintiff‘s injury
    arose directly from the defendant‘s conduct outside California. But in Cornelison
    the defendant‘s out-of-state conduct, his allegedly negligent driving in Nevada,
    was directed (literally) toward California and resulted in injury to a California
    resident. The connections to California that justified jurisdiction in Cornelison are
    missing from the claims of real parties in interest here.
    In Vons, 
    supra,
     
    14 Cal.4th 434
    , we held specific jurisdiction proper over two
    restaurant franchisees based and operating in Washington State. In multiparty
    litigation arising out of food poisoning incidents at their and other Jack-in-the-Box
    restaurants, the supplier of the allegedly tainted meat (Vons Companies, Inc.
    (Vons)) cross-complained against several franchisees, including the Washington
    franchisees, alleging their failure to cook the meat properly caused the poisoning.
    (Id. at pp. 440–441.) Among other contacts with California, the franchisees had
    executed the franchise agreements, which specified methods of preparing Jack-in-
    the-Box food products, in California, did regular business with the franchisor at its
    17
    headquarters in San Diego, and had officers attend training sessions offered by the
    franchisor in California. (Id. at pp. 442–443.)
    We held Vons‘s claims against the franchisees bore a substantial relationship
    to their contacts with California for two reasons: first, the franchise relationship—
    formed in California, under which the franchisees bought meat Vons supplied to
    the franchisor—had drawn Vons and the franchisees into a relationship as alleged
    joint tortfeasors, with certain joint liabilities and rights of indemnification, rights
    upon which Vons‘ cross-complaint in part rested; second, the franchise
    relationship, by imposing uniform standards for cooking food, buying equipment,
    and training employees, was itself an alleged source of Vons‘ injuries, which Vons
    traced to the ― ‗systematically deficient‘ ‖ procedures required by the franchisor.
    (Vons, supra, 14 Cal.4th at pp. 456–457.)
    Real parties in interest rely on Vons for the propositions that for specific
    jurisdiction to be justified the defendant‘s forum activities need not be directed at
    the plaintiff or directly give rise to the plaintiff‘s claims. (See Vons, 
    supra,
     14
    Cal.4th at pp. 453, 457.) Both points are well taken. Nonetheless, in Vons the
    connection between the forum activities and the claim was far more substantial
    than in the present case. By their activities in California, including the formation
    of franchise relationships, the franchisees in Vons established the conditions that
    would ultimately allow the franchisor‘s meat supplier, Vons, to seek indemnity for
    their joint liability and redress for its own injuries. The franchisees‘ forum
    activities were not directed at Vons, with which they had no direct relationship,
    and may not have proximately given rise to Vons‘s claims, but by establishing a
    franchise relationship pursuant to which the franchisees bought Vons‘s meat and
    prepared it according to methods set out in the franchise agreement, they set the
    stage for those claims, to say the least. No such nexus is apparent here, where
    18
    BMS‘s marketing and sales of Plavix in California did nothing to establish the
    circumstances under which it allegedly injured plaintiffs in other states.
    Finally as to California cases, real parties in interest cite Snowney, supra, 
    35 Cal.4th 1054
    , in which we held a California resident could sue a group of Nevada
    hotels in a California court for the hotels‘ failure to provide notice that they would
    impose an energy surcharge on their room prices. (Id. at p. 1059.) In a relatively
    brief discussion of the relatedness issue (the bulk of our analysis concerned the
    question of purposeful availment), we held the plaintiff‘s claims had a substantial
    connection to the defendants‘ California forum activities because the plaintiff‘s
    false advertising and unfair competition claims were based on the hotels‘ alleged
    omissions in their California advertising and in the reservation process. (Id. at
    p. 1068.) ―Because the harm alleged by plaintiff relates directly to the content of
    defendants‘ promotional activities in California, an inherent relationship between
    plaintiff‘s claims and defendants‘ contacts with California exists.‖ (Id. at p. 1069.)
    Real parties rely on Snowney for its adherence to the substantial connection
    test articulated in Vons and for its reiteration of Vons‘s statements that the required
    intensity of forum contacts and connection of the claim to those contacts are
    inversely related (the greater the contacts, the less of a relationship need be shown)
    and that the forum contacts need not be directed at the plaintiff or give rise directly
    to the plaintiff‘s claim. (See Snowney, 
    supra,
     35 Cal.4th at p. 1068.) I find those
    principles unavailing in this case. However intense the defendant‘s activities in
    California, they must still bear a substantial relationship to the plaintiff‘s claims,
    and neither Snowney nor any of the other decisions real parties cite suggests that a
    mere resemblance between the plaintiff‘s claims and those made by other
    plaintiffs that are based on the defendant‘s California contacts establishes a
    substantial connection.
    19
    Cornelison, Vons and Snowney establish that we do not demand the
    relationship between the defendant‘s California contacts and the plaintiff‘s claims
    be causal or direct. They do not, however, support specific jurisdiction on the
    tenuous basis of a resemblance to other claims by other plaintiffs. (See
    Greenwell v. Auto-Owners Ins. Co. (2015) 
    233 Cal.App.4th 783
    , 801 [Vons and
    Snowney require a substantial connection between the plaintiff‘s claims and the
    defendant‘s forum contacts; test is not satisfied whenever there is ―any
    relationship at all‖].)
    In Keeton, 
    supra,
     
    465 U.S. 770
    , the United States Supreme Court upheld the
    assertion of specific jurisdiction in New Hampshire to adjudicate the libel claims
    of a New York resident against an Ohio corporation with its principal place of
    business in California. (Id. at pp. 772–774.) The high court found the defendant‘s
    regular circulation of magazines in New Hampshire was sufficient to support the
    state‘s jurisdiction over a libel claim based on the magazine‘s contents, even
    though the plaintiff could, under the ― ‗single publication rule‘ ‖ followed in New
    Hampshire, recover damages from publication of the magazine throughout the
    United States. (Id. at pp. 773–774.) The court emphasized that the plaintiff was
    suing, in part, for damages she suffered in New Hampshire, ―[a]nd it is beyond
    dispute that New Hampshire has a significant interest in redressing injuries that
    actually occur within the State.‖ (Id. at p. 776.)
    Unlike the plaintiff in Keeton, real parties in interest suffered no injury in
    California or from BMS‘s conduct in California. They nonetheless argue Keeton
    is analogous because the plaintiff there sought recovery, in large part, for injuries
    incurred outside the forum state. For two reasons, however, the analogy does not
    hold.
    First, the single publication rule at work in Keeton was a state law rule
    governing the measure of damages for defamation, not one governing the joinder
    20
    of claims or claimants. The propriety of that state law damages rule was not itself
    a jurisdictional issue; rather, the question was whether personal jurisdiction in
    New Hampshire violated due process given the state‘s single publication rule (and
    its unusually long statute of limitations). (Keeton, supra, 465 U.S. at pp. 773–
    774.) In contrast, BMS‘s motion to quash service of summons as to the claims of
    the nonresident plaintiffs directly presents the jurisdictional issue as to those
    plaintiffs. We ask whether the superior court may take jurisdiction over defendant
    to adjudicate those claims, and are not required to decide whether the entire suit,
    including the claims of the California residents, would be subject to dismissal for
    lack of jurisdiction if the nonresidents‘ claims were included in it.
    Second, New Hampshire had an interest in adjudicating the out-of-state
    damages that does not translate to the factual context of this case. (See Keeton,
    
    supra,
     465 U.S. at p. 777.) To prevent the extraordinary burden on courts and
    litigants of having a defamation plaintiff sue separately in 50 states—and to allow
    effective application of a statute of limitations for publications that continue or
    recur over lengthy periods—most states have adopted the single publication rule,
    allowing only a single action per publication, but one in which all damages from
    the publication may be recovered. (See Civ. Code, § 3425.3 [Cal. Uniform Single
    Publication Act]; Christoff v. Nestlé USA, Inc. (2009) 
    47 Cal.4th 468
    , 477–479;
    see also Keeton, 
    supra, at p. 778
    .)
    On the facts of this case, there is no analogous state interest of similar force
    that would justify California courts adjudicating the nonresident plaintiffs‘ claims.
    This is not a case in which the individual California plaintiffs would be stymied by
    procedural obstacles or restrictive damages rules were the nonresidents excluded
    from the action. Plaintiffs allege they suffered ―severe physical, economic and
    emotional injuries‖ from their use of Plavix, including bleeding ulcers,
    gastrointestinal bleeding, cerebral bleeding, heart attack and stroke. Even if some
    21
    of the California plaintiffs might have individual claims too small to justify suit,
    the consolidation of scores of such claims from within California would remedy
    that insufficiency without the addition of hundreds of nonresidents‘ claims.
    California can thus provide an effective forum for its residents to seek redress
    without joining those claims to similar claims by nonresidents. Nor does this case
    raise the specter of a continually restarting statute of limitations that would subject
    defendants like BMS to the harassment of unending suits for the same conduct
    (see Christoff v. Nestlé USA, Inc., supra, 47 Cal.4th at p. 478), as was the case
    with the defamation suit in Keeton.
    The majority argues jurisdiction over nonresidents‘ claims is justified by the
    efficiencies of litigating all claims arising from a ―mass tort‖ in a single forum and
    by the existence of a complex litigation division in San Francisco Superior Court
    ―well suited to expeditiously handle such large cases.‖ (Maj. opn., ante, at pp. 35,
    34.) If these 678 plaintiffs were all the injured Plavix users in the United States,
    and the only options for the nonresident plaintiffs were participation in this action
    or individual actions in their home states, then joint proceedings in California
    would likely be the most efficient procedure, though the extent of that efficiency
    would depend on how choice of law questions are resolved, among other factors.
    (See Silberman, supra, 19 Lewis & Clark L.Rev. at p. 687 [―As for the efficiency
    arguments relied on by the California appeals court, only the issue of the defective
    quality of the drug is common to all the claims.‖].)
    But these plaintiffs do not constitute the entire universe of those claiming
    injury from Plavix—far from it—and real parties‘ options are not limited to
    joining this action or each bringing separate actions in their respective states. In
    addition to consolidated multidistrict federal litigation in the District of New
    22
    Jersey, individual, mass or representative actions have been brought in several
    other states.3 Whether or not real parties‘ claims are heard together with those of
    the California plaintiffs, inefficiency and the potential for conflicting rulings will
    exist so long as actions are simultaneously pending in several state and federal
    courts. (See generally Miller, Overlapping Class Actions (1996) 71 N.Y.U.
    L.Rev. 514, 520–525.)
    No mechanism exists for centralizing nationwide litigation in a state court;
    there is no means by which pending actions in Illinois courts, for example, can be
    transferred to a California court. The San Francisco Superior Court, no matter
    how well equipped for trying complex cases, cannot adjudicate the entire dispute
    between injured Plavix users and BMS. If efficiency is the goal, federal litigation
    3       See In re Plavix Marketing, Sales Practices and Products Liability
    Litigation (No. II) (U.S. Jud. Panel Multidist. Litig. 2013) 
    923 F.Supp.2d 1376
    ,
    1379–1381 (centralizing in District of New Jersey litigation arising in that state
    and in Illinois, Iowa, Louisiana, New York, and Pennsylvania, and potentially
    centralizing additional actions from California and Mississippi); Mills v. Bristol-
    Myers Squibb Co. (D.Ariz., Aug. 12, 2011, No. CV 11-968-PHX-FJM) 
    2011 WL 3566131
    , at *1 (individual action); Hawaii ex rel. Louie v. Bristol-Myers Squibb
    Co. (D.Hawaii, Aug. 5, 2014, No. CIV. 14-00180 HG-RLP) 
    2014 WL 3865213
    , at
    *2 (parens patriae action brought by the Attorney General of Hawaii remanded to
    state court); Davidson v. Bristol-Myers Squibb Co. (S.D.Ill., Apr. 13, 2012, No.
    CIV. 12-58-GPM) 
    2012 WL 1253165
    , at *5 (action by 83 plaintiffs remanded to
    state court); Boyer v. Bristol-Myers Squibb Co. (S.D.Ill., Apr. 13, 2012, No. CIV.
    12-61-GPM) 
    2012 WL 1253177
    , at *5 (same, as to action by 71 plaintiffs); Anglin
    v. Bristol-Myers Squibb Co. (S.D.Ill., Apr. 13, 2012, No. CIV. 12-60-GPM) 
    2012 WL 1268143
    , at *5 (same, as to action by 67 plaintiffs); Tolliver v. Bristol-Myers
    Squibb Co. (N.D.Ohio, July 30, 2012, No. 1:12 CV 00754) 
    2012 WL 3074538
    , at
    *1 (individual action); Employer Teamsters-Local Nos. 175/505 Health and
    Welfare Trust Fund v. Bristol-Myers Squibb Co. (S.D.W. Va. 2013) 
    969 F.Supp.2d 463
    , 466 (action by third party payors alleging misleading and false
    marketing of Plavix).
    23
    centralized through the multidistrict procedure offers a more promising path than a
    series of uncoordinated state and federal court actions.
    Keeton, in which jurisdiction was found proper despite a state law rule
    allowing damages for out-of-state injuries, thus fails to support real parties‘
    contention that jurisdiction over litigation brought by nonresident plaintiffs whose
    claims arose in other states may be obtained by joining their cases to similar ones
    brought by California plaintiffs. Such jurisdiction by joinder, moreover, would
    run counter to the holding of Hanson v. Denckla (1958) 
    357 U.S. 235
     (Hanson).
    In Hanson, the high court held a Florida court considering the validity of a
    trust created in Delaware did not have personal jurisdiction over the Delaware
    trustee, who had performed no relevant acts in Florida (357 U.S. at p. 252),4 even
    though other parties to the dispute resided in Florida and could be brought before
    the Florida court: ―It is urged that because the settlor and most of the appointees
    and beneficiaries were domiciled in Florida the courts of that State should be able
    to exercise personal jurisdiction over the nonresident trustees. This is a non
    sequitur. With personal jurisdiction over the executor, legatees, and appointees,
    there is nothing in federal law to prevent Florida from adjudicating concerning the
    respective rights and liabilities of those parties. But Florida has not chosen to do
    4       The majority‘s account of Hanson as resting solely on the purposeful
    availment prong of the specific jurisdiction test (maj. opn., ante, at p. 26, fn. 3) is
    incomplete. The trust settlor in Hanson had moved to Florida after establishing
    the trust; the trustee then paid the settlor trust income in that state and received
    from her directions for trust administration, including the execution of two powers
    of appointment. (Hanson, 
    supra,
     357 U.S. at p. 252 & fn. 24.) But because the
    litigation concerned the validity of the trust agreement itself (id. at p. 253), the
    cause of action was ―not one that arises out of an act done or transaction
    consummated in the forum State.‖ (Id. at p. 251.) Hanson‘s holding was thus
    based on the lack of a relationship between the litigation and the defendant‘s
    forum contacts as well as on the paucity of those contacts.
    24
    so. As we understand its law, the trustee is an indispensable party over whom the
    court must acquire jurisdiction before it is empowered to enter judgment in a
    proceeding affecting the validity of a trust. It does not acquire that jurisdiction by
    being the ‗center of gravity‘ of the controversy, or the most convenient location
    for litigation.‖ (Id. at p. 254, fn. omitted.)
    It is likewise a non sequitur to argue that because many Californians have
    sued BMS for injuries allegedly caused by their use of Plavix, and the superior
    court‘s jurisdiction to address their claims is not disputed, the claims of
    nonresidents injured in other states should also be adjudicated here. California
    might or might not be an especially convenient and efficient forum for nationwide
    Plavix litigation, but joinder of California plaintiffs cannot confer personal
    jurisdiction over BMS to adjudicate claims that do not arise out of, and are not
    otherwise related to, BMS‘s business activities in California.
    The majority posits two bases for deeming BMS‘s California activities
    related to the nonresident plaintiffs‘ claims. First, despite a silent factual record
    on this point, the majority infers that BMS employed the ―same . . . assertedly
    misleading marketing and promotion‖ in California as in the states where real
    parties resided and were allegedly injured.5 (Maj. opn., ante, at p. 23.) I have
    shown above that neither the case law nor an analysis of forum state interests
    supports basing specific jurisdiction on a similarity between activities in the forum
    state and those outside the forum. Characterizing BMS‘s multistate marketing
    activities as ―coordinated‖ (maj. opn., ante, at p. 24) adds nothing to the
    5       Despite relying on BMS‘s nationwide marketing of Plavix as a basis for
    jurisdiction, and despite bearing the burden of proof on contacts and relatedness,
    real parties in interest introduced no evidence of particular marketing materials or
    broadcasts deployed in any state.
    25
    jurisdictional argument given that, as the majority concedes, the record shows
    BMS‘s marketing campaign for Plavix was coordinated from New York and New
    Jersey rather than from California. The majority‘s supposition that California
    courts have personal jurisdiction over an out-of-state defendant to adjudicate a
    claim arising from deceptive advertising in, say, Maryland because the defendant
    used a common marketing strategy in California, Maryland and other states is
    without rational foundation.
    Nor does calling BMS‘s nationwide marketing of Plavix a ―course of
    conduct‖ (maj. opn., ante, at pp. 24, 25, 36) advance the majority‘s cause. As
    already noted (fn. 5, ante), real parties introduced no evidence of marketing
    materials or broadcasts used in any state. Other than that some degree of
    commonality existed, which BMS conceded, the extent of marketing overlap
    among the states is simply unknown. Certainly, this record provides no basis for
    assuming that real parties and the California plaintiffs were all injured by a single
    television broadcast made simultaneously in every media market or a single print
    advertisement published simultaneous in newspapers and magazines throughout
    the nation. This is not a case, that is to say, of a single act injuring plaintiffs in
    multiple states at one blow, where the argument for common jurisdiction might be
    stronger. All that appears is that Plavix was marketed nationwide and that BMS
    may have used many of the same materials—none of them generated in
    California—in various states. Such similarity of causes is not sufficient to give
    our courts jurisdiction over all claims, wherever they arise, based on
    misrepresentations or omissions in a company‘s marketing materials.
    Second, the majority notes that BMS maintains some research facilities in
    California, although the majority concedes Plavix was not developed in those
    26
    facilities.6 (Maj. opn., ante, at p. 24.) This second ground of relatedness is both
    illogical and startling in its potential breadth. Because BMS has performed
    research on other drugs in California, claims of injury from Plavix may, according
    to the majority, be adjudicated in this state. Will we in the next case decide that a
    company may be sued in California for dismissing an employee in Florida because
    on another occasion it fired a different employee in California, or that an Illinois
    resident can sue his automobile insurer here for bad faith because the defendant
    sells health care policies in the California market? The majority points to no
    substantial connection between Plavix claims arising in other states and research
    on unspecified other products in this state.
    II. The Relatedness Requirement Serves Important Functions and
    Should Not Be Minimized
    As shown in part I, ante, the case law on specific jurisdiction does not
    support a California court taking jurisdiction over nonresident plaintiffs‘ claims,
    arising from their use of Plavix in other states. BMS marketed and sold Plavix to
    other plaintiffs within California, but those forum activities are not substantially
    related to the nonresident plaintiffs‘ claims. In the absence, however, of any
    United States Supreme Court decisions closely on point, stare decisis does not
    prevent the majority from giving the relatedness requirement scant consideration,
    while relying on its theory that the asserted benefits of consolidating multistate
    claims in California outweigh the burdens for BMS of defending real parties‘
    6     This is not a matter of the absence of evidence. In support of its motion to
    quash service, a BMS executive submitted a declaration stating that ―none of the
    work to develop Plavix took place in California,‖ and that all development,
    manufacture, labeling, and marketing of Plavix was performed or directed from
    New York or New Jersey; none was accomplished or directed by California
    employees.
    27
    claims here together with those of the California plaintiffs. (Maj. opn., ante, at
    pp. 29–35.) Nevertheless, this approach is, in my view, a serious mistake. By
    essentially ignoring relatedness and merely satisfying itself that defendant is not
    being haled into an inconvenient forum where it has no significant contacts, the
    majority blurs the distinction between general and specific jurisdiction and impairs
    the values of reciprocity, predictability, and interstate federalism served by due
    process limits on personal jurisdiction.
    Reciprocity, in this context, refers to the idea that the litigation to which a
    defendant is exposed in a particular forum should bear some relationship to the
    benefits the company has sought by doing business in the state. (See Moore, The
    Relatedness Problem in Specific Jurisdiction (2001) 37 Idaho L.Rev. 583, 599
    [―The party has garnered the benefits offered by the government in which the
    court sits. These benefits include the laws, the administrative framework and their
    restraining effects. In return, the party concedes to that government a quantum of
    power to govern his conduct, a power which he himself holds in a natural
    autonomous state.‖].) Such reciprocity is most clearly maintained by the state
    taking jurisdiction over disputes arising directly from the defendant‘s activities in
    the state. As the high court said in International Shoe, where ―[t]he obligation
    which is . . . sued upon arose out of those very activities,‖ it will generally be
    ―reasonable and just . . . to permit the state to enforce the obligations which
    appellant has incurred there.‖ (International Shoe, 
    supra,
     326 U.S. at p. 320.)
    More broadly, enforcing a meaningful relatedness requirement ensures some
    degree of reciprocity; because the forum‘s assertion of jurisdiction cannot
    encompass disputes that have no substantial connection with the defendant‘s
    forum activities, the liabilities to which the defendant is exposed in the forum will
    tend to bear a relationship to the benefits it has sought in doing business there.
    ―Relationship helps test whether the benefits and burdens are similar. When a suit
    28
    concerns the activities from which the corporation received in-state benefits, there
    is some similarity in the burden imposed by the assertion of jurisdiction. . . .
    Relatedness may be a rough measure, but it placed a logical limit on the burdens
    arising from in-state activities.‖ (Andrews, The Personal Jurisdiction Problem
    Overlooked in the National Debate About “Class Action Fairness” (2005) 58
    SMU L.Rev. 1313, 1345–1346 (hereafter Andrews).)
    Relatedness bears on predictability in much the same way. ―In order for a
    business to properly structure its behavior—set consumer costs, procure insurance,
    or sever its relationship with a particular state—it must not only know that a
    contact has been made in a particular state (an aim protected through the
    purposeful availment standard), but it also must have some minimal appreciation
    of the effect of that contact. The relationship standard helps give this knowledge.
    If a business entity chooses to enter a state on a minimal level, it knows that under
    the relationship standard, its potential for suit will be limited to suits concerning
    the activities that it initiates in the state.‖ (Andrews, supra, 58 SMU L.Rev. at
    p. 1346; see World-Wide Volkswagen Corp. v. Woodson (1980) 
    444 U.S. 286
    , 297
    (World-Wide Volkswagen) [observing that when a corporation sells its products in
    a state, ―it has clear notice that it is subject to suit there,‖ and jurisdiction over a
    suit would not be unreasonable ―if its allegedly defective merchandise has there
    been the source of injury to its owner or to others.‖].)
    Finally, limiting specific jurisdiction to litigation that is substantially
    connected to the defendant‘s forum activities prevents states from straying beyond
    their legitimate regulatory spheres. Appropriately limited, specific jurisdiction
    ―acts to ensure that the States, through their courts, do not reach out beyond the
    limits imposed on them by their status as coequal sovereigns in a federal system.‖
    (World-Wide Volkswagen, 
    supra,
     444 U.S. at p. 292.) As the high court explained
    in Hanson, the growth in interstate commerce and the easing of communications
    29
    and transportation may have tempered, but they have not eliminated, the role that
    territorial limits on state regulation play under due process. Due process
    restrictions on personal jurisdiction ―are more than a guarantee of immunity from
    inconvenient or distant litigation. They are a consequence of territorial limitations
    on the power of the respective States.‖ (Hanson, supra, 357 U.S. at p. 251.)
    Expanding on this point in World-Wide Volkswagen, the court explained that
    while the Constitution‘s Framers foresaw a nation of economically interdependent
    states, they ―also intended that the States retain many essential attributes of
    sovereignty, including, in particular, the sovereign power to try causes in their
    courts. The sovereignty of each State, in turn, implied a limitation on the
    sovereignty of all of its sister States—a limitation express or implicit in both the
    original scheme of the Constitution and the Fourteenth Amendment.‖ (World-
    Wide Volkswagen, supra, 444 U.S. at p. 293.) Thus even in the modern era due
    process limits on personal jurisdiction retain a territorial aspect: ―Even if the
    defendant would suffer minimal or no inconvenience from being forced to litigate
    before the tribunals of another State; even if the forum State has a strong interest
    in applying its law to the controversy; even if the forum State is the most
    convenient location for litigation, the Due Process Clause, acting as an instrument
    of interstate federalism, may sometimes act to divest the State of its power to
    render a valid judgment.‖ (Id. at p. 294; accord, J. McIntyre Machinery, Ltd. v.
    Nicastro (2011) 
    564 U.S. 873
    , 879 (plur. opn. of Kennedy, J.) [―The Due Process
    Clause protects an individual‘s right to be deprived of life, liberty, or property
    only by the exercise of lawful power. . . . This is no less true with respect to the
    power of a sovereign to resolve disputes through judicial process than with respect
    30
    to the power of a sovereign to prescribe rules of conduct for those within its
    sphere.‖].)7
    The relatedness requirement for specific jurisdiction plays a key role in
    implementing these interstate federalism limits. By conducting business within a
    state or directing its efforts at the state, a company brings its activities within the
    state‘s core regulatory concerns. Litigation that arises from those activities falls
    squarely within the state‘s sovereign power to adjudicate. In contrast, litigation
    arising outside the state is unlikely to be a fit subject for state court adjudication
    except to the extent it involves state residents. ―A state has sovereignty with
    regard to activity conducted within its borders, and it thus has power over claims
    arising from that activity. . . . A state seemingly has no sovereignty over activity
    that neither involves its citizens nor occurs within its borders.‖ (Andrews, supra,
    58 SMU L.Rev. at p. 1347.) Relatedness thus ―helps limit the reach of states so
    that they do not exceed legitimate state interests.‖ (Id. at p. 1348.) As this court
    remarked (in a choice of law discussion, but with equal applicability to
    jurisdiction), our state‘s legitimate regulatory interest does not ordinarily extend to
    measures aimed at ―alter[ing] a defendant‘s conduct in another state vis-à-vis
    another state‘s residents.‖ (Kearney v. Salomon Smith Barney, Inc. (2006) 
    39 Cal.4th 95
    , 104, italics omitted.)
    7  In Insurance Corp. of Ireland, Ltd. v. Compagnie des Bauxites de Guinee
    (1982) 
    456 U.S. 694
    , 703, footnote 10, the high court noted that concern for
    federalism is not ―an independent restriction on the sovereign power of the court,‖
    but rather ―a function of the individual liberty interest preserved by the Due
    Process Clause,‖ waivable by the party. Though not an independent, unwaivable
    restriction on jurisdiction, interstate federalism remains an important consideration
    in determining how the due process limits on jurisdiction should be applied. ―The
    defendant has a due process right to have states act only within the limits of their
    sovereignty.‖ (Andrews, supra, 58 SMU L.Rev. at p. 1347.)
    31
    Basing specific jurisdiction on mere similarity between a corporation‘s forum
    activities and those outside the state, as the majority does in this case, defeats the
    relatedness requirement‘s functions of reciprocity, predictability, and interstate
    federalism. If BMS must answer in a California court for Plavix claims arising
    across the country simply because some Californians have made similar claims,
    the link between the benefits BMS has sought by doing that business in the state
    and the liabilities to which it is exposed here has been severed. In the same way,
    predictability has been severely impaired, as the company‘s potential liabilities
    cannot be forecast from its state activities. And interstate federalism is perhaps
    most directly impaired; by taking jurisdiction to adjudicate a dispute arising only
    from BMS‘s actions in, for example, Texas, and allegedly resulting in injuries
    only to a Texan, the California courts infringe directly on Texas‘s sovereign
    prerogative to determine what liabilities BMS should bear for actions in its borders
    and injuring its residents. ―[T]he forum state arguably exceeds its sovereignty
    when it asserts jurisdiction over claims that are merely similar to activities within
    its borders, as opposed to causally connected to the forum conduct.‖ (Andrews,
    supra, 58 SMU L.Rev. at pp. 1354–1355.)
    For decades, commentators have rejected similarity as an adequate criterion
    of connection or relatedness, recognizing that its excessive breadth would create
    jurisdiction in every state for every breach by a national corporation, wherever it
    occurred. ―Thus the similarity test would apparently have to allow jurisdiction in
    any State in the country where the defendant has engaged in similar activities.‖
    (Brilmayer, How Contacts Count: Due Process Limitations on State Court
    Jurisdiction (1980) Sup.Ct.Rev. 77, 84; accord, Rhodes & Robertson, Toward a
    New Equilibrium in Personal Jurisdiction (2014) 48 U.C. Davis L.Rev. 207, 242
    [allowing specific jurisdiction ―in every forum in which the defendant conducts
    continuous and systematic forum activities that are sufficiently similar to the
    32
    occurrence in dispute . . . would give the plaintiff the choice of essentially every
    state for proceeding against a national corporation‖].) Today, the majority, by
    holding the presence of California plaintiffs with claims similar to those of real
    parties in interest constitutes a substantial connection between real parties‘ claims
    and BMS‘s California activities, effectively sanctions California courts taking
    jurisdiction over actions by plaintiffs throughout the nation alleging injuries from
    any nationwide business activity.
    As California holds a substantial portion of the United States population, any
    company selling a product or service nationwide, regardless of where it is
    incorporated or headquartered, is likely to do a substantial part of its business in
    California. Under the majority‘s theory of specific jurisdiction, California
    provides a forum for plaintiffs from any number of states to join with California
    plaintiffs seeking redress for injuries from virtually any course of business conduct
    a defendant has pursued on a nationwide basis, without any showing of a
    relationship between the defendant‘s conduct in California and the nonresident
    plaintiffs‘ claims. The majority thus sanctions our state to regularly adjudicate
    disputes arising purely from conduct in other states, brought by nonresidents who
    suffered no injury here, against companies who are not at home here but simply do
    business in the state.
    Such an aggressive assertion of personal jurisdiction is inconsistent with the
    limits set by due process. Although those limits are more flexible and less strictly
    territorial than in the past, the high court has explained that they still act to keep
    any one state from encroaching on the others: ―[W]e have never accepted the
    proposition that state lines are irrelevant for jurisdictional purposes, nor could we,
    and remain faithful to the principles of interstate federalism embodied in the
    Constitution.‖ (World-Wide Volkswagen, 
    supra,
     444 U.S. at p. 293.) That BMS
    marketed and sold Plavix throughout the United States, presumably using much of
    33
    the same advertising in many markets, does not give California authority, under
    our federal system, to assert jurisdiction over claims arising throughout the nation.
    Speaking of the limits to jurisdiction set by interstate federalism, the court in
    Boaz—also involving a pharmaceutical drug marketed throughout the nation—
    observed: ―We have no warrant to jettison these principles in favor of an approach
    which recognizes no defined limits to the assertion of jurisdiction against any
    defendant whose national marketing somehow affects commerce in the forum
    state.‖ (Boaz, supra, 40 Cal.App.4th at p. 721.)
    Assessing the fairness of specific jurisdiction ― ‗in the context of our federal
    system of government‘ ‖ (World-Wide Volkswagen, 
    supra,
     444 U.S. at pp. 293–
    294), we should be restrained here by the absence of any discernable state interest
    in adjudicating the nonresident plaintiffs‘ claims. Where the conduct sued upon
    did not occur in California, was not directed at individuals or entities in California,
    and caused no injuries in California or to California residents, neither our state‘s
    interest in regulating conduct within its borders (Vons, supra, 14 Cal.4th at p. 472)
    nor its interest in providing a forum for its residents to seek redress for their
    injuries (id. at p. 473) is implicated. On the critical question of why a Texan‘s
    claim he was injured in Texas by taking Plavix prescribed and sold to him in
    Texas should be adjudicated in California, rather than Texas (or in Delaware or
    New York, BMS‘s home states), the majority offers no persuasive answer.
    34
    CONCLUSION
    Like the majority, I conclude BMS, despite its significant business activities
    in California, is not at home in our state for purposes of asserting general personal
    jurisdiction over it. But neither, in my view, is specific jurisdiction over the
    nonresident plaintiffs‘ claims proper. No substantial connection has been shown
    between BMS‘s activities in California and the nonresidents‘ claims, which arose
    out of BMS‘s marketing and sales of Plavix in other states.
    For this reason, I respectfully dissent.
    WERDEGAR, J.
    WE CONCUR:
    CHIN, J.
    CORRIGAN, J.
    35
    See next page for addresses and telephone numbers for counsel who argued in Supreme Court.
    Name of Opinion Bristol-Myers Squibb Company v. Superior Court
    __________________________________________________________________________________
    Unpublished Opinion
    Original Appeal
    Original Proceeding
    Review Granted XXX 
    228 Cal.App.4th 605
    Rehearing Granted
    __________________________________________________________________________________
    Opinion No. S221038
    Date Filed: August 29, 2016
    __________________________________________________________________________________
    Court: Superior
    County: San Francisco
    Judge: John E. Munter
    __________________________________________________________________________________
    Counsel:
    Lea Brilmayer; Horvitz & Levy, Jon B Eisenberg; Arnold & Porter, Jerome B. Falk, Jr., Sean M. SeLegue,
    Sharon D. Mayo, Jeremy McLaughlin, Steven G. Reade, Daniel S. Pariser, Anna K. Thompson, Maurice A.
    Letter and Anand Agneshwar for Petitioner.
    Mayer Brown and Donald M. Falk for Chamber of Commerce of the United States of America, California
    Chamber of Commerce and Pharmaceutical Research and Manufacturers of America as Amici Curiae on
    behalf of Petitioner.
    Goodwin Proctor, Richard A. Oetheimer, Sarah K. Frederick, David J. Zimmer and Claire C. Jacobson for
    Generic Pharmaceutical Association as Amicus Curiae on behalf of Petitioner.
    Pepper Hamilton, Nicholas M. Kouletsis, Christopher W. Wasson and Eric S. Wolfish for American Tort
    Reform Association, National Association of Manufacturers, National Federation of Independent Business
    and Juvenile Products Manufacturers Association as Amici Curiae on behalf of Petitioner.
    Utrecht & Lenvin and Paul F. Utrecht for Washington Legal Foundation as Amicus Curiae on behalf of
    Petitioner.
    No appearance for Respondent.
    Napoli Bern Ripka Shkolnik, Kelly McMeekin, Hunter J. Shkolnik, John Lytle, Jessica Y. Lee, Shayna E.
    Sacks, Priya Gandhi; Audet & Partners, William M. Audet, Joshua C. Ezrin, Mark E. Burton; Esner, Chang
    & Boyer and Stuart B. Esner for Real Parties in Interest.
    J. Burton LeBlanc; Andrus Anderson, Lori E. Andrus, Jenny Lee Anderson; Law Offices of Collyn A.
    Peddie and Collyn A. Peddie for American Association for Justice as Amicus Curiae on behalf of Real
    Parties in Interest.
    The Arkin Law Firm, Sharon J. Arkin; Robbins Geller Rudman & Dowd and Kevin K. Green for
    Consumer Attorneys of California as Amicus Curiae on behalf of Real Parties in Interest.
    Counsel who argued in Supreme Court (not intended for publication with opinion):
    Anand Agneshwer
    Arnold & Porter
    399 Park Avenue
    New York, NY 10022-4690
    (212) 715-1000
    Stuart B. Esner
    Esner, Chang & Boyer
    234 East Colorado Boulevard, Suite 750
    Pasadena, CA 91101
    (626) 535-9860